Clinical trials: Pandemic Response
COVID-19, Vaccination
Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases
Background: Vaccines against SARS-CoV-2, the virus that causes COVID-19, have been highly effective against preventing severe disease. But the protective effects of these vaccines appear to wane over time.
- Conditions
- COVID-19, Vaccination, Healthy Volunteer
- Trial name
- NCT05078905
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
COVID-19 Infection
Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The global outbreak of COVID-19 is a major public health problem. COVID-19 causes a wide range of symptoms.
- Trial name
- NCT04582903
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stress, Anxiety
Post-Pandemic Perception of Public Space in Singapore
In this study it is aimed to investigate the difference between the brain response to different urban environments in Singapore before and after the COVID-19 pandemic.
- Trial name
- NCT04394039
- Testing
- Public space exposure
- Where
- Singapore
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Avian Influenza
Evaluation of Priming Effects by PLAI Vaccine on the Subsequent Response to Inactivated H5N1 Vaccine
This study aim to compare immunogenicity of the inactivated H5 influenza vaccine single dose between subjects previously vaccinated with LAIV H5N2 and naïve subjects
- Trial name
- NCT02229357
- Testing
- OrniFlu® inactivated vaccine
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dementia
Group CST Using Zoom: A Proof of Concept Study
People living with dementia (PLWD) often struggle to access services and treatment which may benefit their emotional and cognitive wellbeing, as well as disease progression.
- Trial name
- NCT04695743
- Testing
- Online Cognitive Stimulation Therapy
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College, London
COVID-19 Pandemic, Emergencies
Towards Better Preparedness for Future Catastrophes - Local Lessons-learned From COVID-19
The research question of this study is: "what lessons have been learned from the civil-military cooperation in Heidelberg, Germany, during the COVID-19 pandemic, and what needs to be done to be better prepared for future…
- Trial name
- NCT05552989
- Testing
- this is a non-interventional study
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Heidelberg
COVID19
Clinical Validation of New Injection Molded Flocked Nasopharyngeal Swabs in Response to the COVID-19 Pandemic
The SARS-CoV-2 pandemic has resulted in an international shortage of the nasopharyngeal (NP) swabs used to collect sample for virological testing.
- Trial name
- NCT04368260
- Testing
- Control swab, Prototype swab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Influenza
Evaluation of the Immune Response and the Safety of a Pandemic Influenza Candidate Vaccine (H1N1)
The objective of the study is to evaluate the immunogenicity and safety of GSK Biologicals' investigational vaccine GSK2340272A.
- Trial name
- NCT00971425
- Testing
- Pandemrix (GSK investigational influenza GSK2340272A vaccine), Fluarix™
- Where
- 6 sites in Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
COVID-19, SARS-CoV-2 Infection
Clinical Characteristics and Outcomes of Pediatric COVID-19
Rationale: The clinical manifestations of SARS-CoV-2 infection in children are poorly characterized. Preliminary findings indicate that they may be atypical.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Pediatric ALL, Pneumonia, Viral
- Trial name
- PERN-COVID-19 (NCT04330261)
- Testing
- Exposure (not intervention) - SARS-CoV-2 infection
- Where
- Canada
- Volunteers
- 10,610 people
- Sponsor
- University of Calgary
COVID-19, Bariatric Surgery Candidate
Bariatric Surgery and COVID-19
The National Bariatric Surgical Registry (NBSR) is a prospectively collected database for all patients undergoing elective bariatric surgery in the UK.
- Trial name
- NCT05532891
- Testing
- COVID-19 pandemic
- Where
- United Kingdom
- Volunteers
- 11,545 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Influenza
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010
This study will investigate response to influenza vaccines in monozygotic and dizygotic twins of different ages.
- Trial name
- NCT03022396
- Testing
- High Dose Fluzone® (intramuscular), Fluzone® (intramuscular)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Stanford University
Covid19
Response of Korean Medicine Hospital to COVID-19
The objectives of this study are to report the response strategy to prevent COVID-19 spread implemented at a Korean medicine hospital, and the satisfaction survey results regarding its preventive measures.
- Trial name
- NCT04529447
- Testing
- Survey
- Where
- South Korea
- Volunteers
- 485 people, healthy volunteers welcome
- Sponsor
- Jaseng Hospital of Korean Medicine
Influenza, Virus Diseases
Group Study of the Safety of and Immune Response to a Single Dose of Bird Flu Vaccine (H7N3) in Healthy Adults
Over the past decade, avian influenza (AI) has become a major health concern. The development of safe and effective vaccines against avian strains that infect people is important.
- Trial name
- NCT00853255
- Testing
- Live Influenza A Vaccine H7N3 (6-2) AA ca Recombinant (A/chicken/British Columbia/CN-6/2004 x A/Ann Arbor/6/60 ca)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza, Human
Study of Immune Responses in Healthy Adults Receiving Live Influenza Virus Vaccines
This study seeks to understand the host factors that affect the replication and immune response of seasonal and candidate pandemic live attenuated influenza vaccine (LAIV) in humans and to develop biomarkers that can predict the…
- Trial name
- NCT01674205
- Testing
- A/swine/Missouri/4296424/2006 (H2N3) x A/Ann Arbor/6/60 ca (H2N3 MO 2006/AA ca), A/chicken/Hong Kong/G9/97 (H9N2) x A/Ann Arbor/6/60 ca (H9N2 G9/AA ca), 2012-2013 trivalent seasonal live attenuated influenza vaccine (FluMist®)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
SARS-CoV Infection, Covid19
The CHILD Cohort COVID-19 Add-On Study
The objective of this study is to determine the prevalence and transmission of SARS-CoV-2 infection among Canadian children and parents in the CHILD cohort, identify predictors of infection susceptibility and severity, and…
- Trial name
- NCT05234359
- Testing
- Serology Testing, Stool sample
- Where
- Canada
- Volunteers
- 5,385 people
- Sponsor
- University of Manitoba
Anxiety, Healthy Volunteers
Impact on Anxiety and Motivation of COVID-19 and Predictors of Individual Responses
Background: Researchers think that people s mental health and behavior will be very affected by the steps taken to slow the spread of COVID-19, such as social distancing.
- Trial name
- NCT04377100
- Testing
- Computer task questionnaires
- Where
- United States
- Volunteers
- 2,962 people
- Sponsor
- National Institute of Mental Health (NIMH)
Coronavirus, Trust
Migrant Workers' Responses to the COVID-19 Pandemic
Rumors circulate widely during public health crises and have deleterious consequences. In this study, we seek to document the base rates of migrant workers' rumor exposure and identify predictors of rumor hearing, sharing and…
- Conditions
- Coronavirus, Trust, Misinformation
- Trial name
- NCT04718519
- Where
- Singapore
- Volunteers
- 1,011 people, healthy volunteers welcome
- Sponsor
- Yale-NUS College
Sepsis, Vitamin C
Lessening Organ Dysfunction With VITamin C
LOVIT is a multicentre concealed-allocation parallel-group blinded randomized controlled trial to ascertain the effect of high-dose intravenous vitamin C compared to placebo on mortality or persistent organ dysfunction at 28 days…
- Conditions
- Sepsis, Vitamin C, Intensive Care Unit, COVID-19
- Trial name
- LOVIT (NCT03680274)
- Testing
- Vitamin C, Control
- Where
- Canada
- Volunteers
- 872 people
- Sponsor
- Université de Sherbrooke
Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2
Paediatric Inflammatory Multisystem Syndrome During COVID-19 Pandemic
During the COVID-19 pandemic, a small minority of children have been presenting to acute paediatric services with a new syndrome, Paediatric Inflammatory Multisystem Syndrome temporally associated with SARS-Cov-2 (PIMS-TS).
- Trial name
- NCT04761913
- Where
- 6 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Anglia Ruskin University