Clinical trials: Pancreatic Fistula
Pancreatic Tumor
Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Under the hypothesis that collagen-based hemostatic agents improve the suppression of leakage of hemostatic pancreatic fluid at the surgical site during surgery, thrombin-containing collagen-based hemostatic agents are applied in…
- Trial name
- TCM (NCT04357483)
- Testing
- flowable thrombin containing collagen hemostat matrix, thrombin coated L-dopa contained collagen patch
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Fistula
A Prospective Randomized Trial of Efficacy of Stump Closure for Distal Pancreatectomy
Overall morbidity rate remained high after distal pancreatectomy (DP), ranging from 30% to 60%. Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP (12% to…
- Trial name
- NCT03201653
- Testing
- Stump closure using NU-KNIT SURGICEL
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Pancreas Cancer, Fistula
Study Assessing the Effect of Transpapillary Pancreas Duct Stent in Resection of the Pancreatic Tail
Randomized study assessing the effect of transpapillary pancreas duct stent in resection of the pancreatic tail.
- Trial name
- NCT00500968
- Testing
- stent, Distal pancreatectomy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Tumors
Reduced Pancreatic Fistula Rate Following Pancreaticoduodenectomy: Trial on Pancreaticogastrostomy Versus Pancreaticojejunostomy
The incidence of complications after pancreaticoduodenectomy (PD) is around 50 %. The postoperative course after PD is strongly dependent of the occurrence of pancreatic fistula (POPF), which determines postoperative mortality…
- Trial name
- NCT00830778
- Testing
- Pancreaticojejunostomy, Pancreaticogastrostomy
- Where
- Belgium
- Volunteers
- 336 people
- Sponsor
- Baki Topal
Pancreas Cancer, Pancreas Neoplasm
Prognostic Factors in Periampullary Tumors and Cysts
The project aims at analysing prognostic and predictive factors involved in diagnostics and surgical treatment of cysts and tumors in the pancreas and periampullary region using both clinical data and blood and tissue samples for…
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Pancreas Cyst, Pancreatic Fistula
- Trial name
- NCT05155878
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Pancreatic Cancer
Predicting Pancreatic Fistula After Pancreatic Surgery Using Preoperative Immunity
The goal of this observational study is to develop and validate a preoperative immunological signature for predicting postoperative pancreatic fistula (POPF) in adult patients undergoing pancreatic surgery for pancreatic cancer.
- Trial name
- NCT07827911
- Testing
- blood sampling
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Institut Paoli-Calmettes
Cancer of Pancreas
Pancreatico Enteric Anastomosis Post Pancreaticoduodenectomy
The aim of this study is to make a step for evaluation and presentation of a safe technique for pancreatico-jejunostomy that help in minimizing post-operative morbidity and mortality in pancreatic cancer patient by comparing…
- Trial name
- PEAPP (NCT05163977)
- Testing
- Blumgart Anastomosis, Cattell Warren Anastomosis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Pancreatic Diseases
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
The Effect of Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide on the Complications After Pancreatectomy. A Prospective, Multicenter Clinical Trial
- Trial name
- NCT03398941
- Testing
- Preoperative Long Period Octreotide Combined With Postoperative Short Period Octreotide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chengfeng Wang
Pancreatic Cancer, Bile Duct Cancer
Randomized Controlled Trial on Pancreatic Stent Tube in Pancreaticoduodenectomy
The purpose of this study is to determine which stent type is effective in the decrease of postoperative stay and complications across pancreaticojejunostomy after pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Ampullary Cancer, Pancreatitis
- Trial name
- NCT00628186
- Testing
- external drainage tube [polyethylene pancreatic drainage tube], internal drainage tube [polyethylene pancreatic drainage tube]
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Wakayama Medical University
Surgical Complications
Impact of Pasireotide on Postoperative Pancreatic Fistulas Following Distal Resections
Between 2000 and 2016 258 distal pancreatectomies were performed at our University Hospital which were included in our analysis. Pasireotide was used in between July 2014 and April 2016.
- Trial name
- NCT04281680
- Testing
- Pasireotide 0.9 MG/ML
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Pancreaticoduodenectomy
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the standard treatment for tumors of the pancreatic head, distal bile duct, duodenum, and ampulla of Vater.
- Trial name
- NCT06322680
- Testing
- Main pancreatic duct and biliary duct external drainage, Main pancreatic duct and biliary duct internal drainage
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Zhongshan Hospital
Periampullary Carcinoma, Pancreatic Cancer
Reoperation After Pancreaticoduodenectomy
The aim of this study is to outline the incidence of early and late reoperation after PD, examine the risk factors for early surgical intervention and its impact on the surgical outcome, hospital stay, diseases recurrence and…
- Trial name
- NCT04387903
- Testing
- Surgical re-interventionafter pancreaticoduodenectomy
- Volunteers
- 1,000 people
- Sponsor
- Mansoura University
Pancreatic Fistula
External Pancreatic Stent in Pancreaticojejunostomy
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend pancreatic stent in pancreatojejunostomy.
- Trial name
- NCT06743516
- Testing
- Pancreaticojejunostomy with external stent, Pancreaticojejunostomy without external stent
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Pancreas Disease, Complication,Postoperative
Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist)
Main indications for distal pancreatectomy (DP) are pancreatic body and tail tumors including ductal adenocarcinoma, neuroendocrine tumors, and cystic neoplasms.
- Conditions
- Pancreas Disease, Complication,Postoperative, PROMs, Pancreatic Fistula
- Trial name
- Early-Dist (NCT04609137)
- Testing
- Early drain removal, Standard drain removal
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein
Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein, Albumin
- Trial name
- popf (NCT06300801)
- Testing
- Is the preoperative c-reactive protein/albumin ratio successful in predicting postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy?
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Pancreas Neoplasm
Risk Factors for Postoperative Pancreatic Fistula Following Non-traumatic Pancreatic Surgery. Retrospective Observational Study.
Postoperative pancreatic fistula is a potentially fatal sequela with substantial morbidity and mortality. A retrospective observational study was conducted in the surgical unit of Zagazig university hospital .
- Trial name
- NCT05711433
- Testing
- pancreatic surgery
- Volunteers
- 347 people
- Sponsor
- Zagazig University
Pancreatic Cancer, Periampullary Carcinoma
Shark Mouth Modified Pancreaticojejunostomy
Pancreaticoduodenectomy (PD) is one of the most complicated surgical procedure and one of the standard treatments for benign and malignant disease of pancreatic head and periampullary region.
- Trial name
- SMMP (NCT03366038)
- Testing
- Shark Mouth Modified Pancreaticojejunostomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Pancreatic Fistula, Pancreas Neoplasm
Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreaticoduodenectomy
Background: postoperative pancreatic fistula (POPF) remains the most important morbidity after pancreaticoduodenectomy (PD). There is no consensual technique for pancreatic reconstruction and many surgeons use a transanastomotic…
- Conditions
- Pancreatic Fistula, Pancreas Neoplasm, Stent Disintegration, Pancreatic Cancer
- Trial name
- NCT04783831
- Testing
- Biodegradable stent
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca