Clinical trials: Pancreatectomy; Hyperglycemia
Pancreatectomy; Hyperglycemia, Diabete Mellitus
Glucose Metabolism After Partial Pancreatectomy
This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.
- Trial name
- NCT04409171
- Testing
- oral glucose tolerance test
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hyperinsulinism, Diabetes
Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes
This is a pilot study designed to determine if the bihormonal bionic pancreas provides improved blood glucose control, compared to the current standard of care, in individuals with hyperinsulinism who developed diabetes after…
- Conditions
- Hyperinsulinism, Diabetes, Pancreatic Diseases, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03303196
- Testing
- Bihormonal Bionic Pancreas
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia
A Prospective Observational Study of TPIAT
Multi-center, prospective, observational cohort study of patients undergoing total pancreatectomy with islet autotransplantation (TPIAT)
- Conditions
- Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia, Pancreatitis
- Trial name
- POST (NCT03260387)
- Testing
- TPIAT
- Where
- 12 sites in United States
- Volunteers
- 433 people
- Sponsor
- University of Minnesota
Pancreatectomy; Hyperglycemia
Separate and Combined Extrapancreatic Effects of the Incretin Hormones
The two gut-derived hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) is secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas.
- Trial name
- GA-19 (NCT05177653)
- Testing
- Intravenous infusion
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 1 Diabetes
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
This research is being done to better understand how insulin effects muscle, blood, and the body in people with Type 1 Diabetes.
- Trial name
- NCT05985135
- Testing
- Muscle Biopsy, Jell-O with Amino acids, Dextrose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postpancreatectomy Hyperglycemia
Islet Autotransplantation in Patients at Very High-risk Pancreatic Anastomosis
The goal of the proposal is to demonstrate that, in patients with disease of the pancreatic head with very high-risk of complications of pancreatojejunal reconstruction (soft pancreas and pancreatic duct diameter <3 mm), total…
- Trial name
- PAN-IT (NCT01346098)
- Testing
- Pancreaticoduodenectomy with pancreatic anastomosis, Total pancreatectomy with islet autotransplantation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedale San Raffaele
Pancreas Cancer, Pancreatectomy; Hyperglycemia
Evaluation of the Impact of Pancreatectomy on Systemic Immunity
The study aims at establishing the profile of the immune reaction that occurs in the early surgical suites after pancreatectomy.
- Trial name
- IMMUNOPANC (NCT03978702)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Institut Paoli-Calmettes
Type 1 Diabetes, Pancreatectomy; Hyperglycemia
Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
In this study, liver samples will be collected, processed and stored in a specialized, clinical grade, cell bank for potential future clinical use.
- Trial name
- NCT04038931
- Testing
- Liver biopsy collection
- Volunteers
- 20 people
- Sponsor
- Orgenesis Ltd.
Postoperative Hyperglycemia, Pancreatectomy
Postoperative Insulin Intervention After Pancreatectomy in nDM Patients
The goal of this randomized non-inferiority clinical trial is to evaluate whether routine postoperative insulin infusion can be safely omitted in preoperative non-diabetic adult patients undergoing pancreatectomy for…
- Trial name
- NCT07540975
- Testing
- Insulin Infusion, No Insulin Infusion (Standard Monitoring Only)
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Dae Wook Hwang
Pancreatectomy; Hyperglycemia
Separate and Combined Extrapancreatic Effects of GIP and GLP-1
The two gut-derived hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted from intestinal cells in relation to a meal and increase insulin secretion from the pancreas.
- Trial name
- GA-19b (NCT06895408)
- Testing
- Intravenous Infusion
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Pancreatic Leak, Pancreatic Fistula
A Phase II Trial of Lanreotide for the Prevention of Postoperative Pancreatic Fistula
This is a single arm investigator-initiated study designed to test the feasibility and potential efficacy of preoperative lanreotide to reduce the risk of postoperative abscess or pancreatic leak and fistula.
- Conditions
- Pancreatic Leak, Pancreatic Fistula, Pancreaticoduodenal; Fistula, Pancreatectomy; Hyperglycemia
- Trial name
- NCT03174353
- Testing
- Lanreotide Prefilled Syringe
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Washington
Impaired Glucose Tolerance
The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
The purpose of this study is to examine changes in sugar metabolism that may occur in subjects who have previously had part of their pancreas removed due to a benign lesion.
- Trial name
- Pilot OGTT (NCT00841867)
- Testing
- All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles