Clinical trials: Palliative Care, open to volunteers
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Intractable Pain, Palliative Care
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like plant.
- Trial name
- NCT00804154
- Testing
- Intrathecal Resiniferatoxin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Primary Caregiver Readiness for Care and Psychological Resilience in Palliative Care
Nurse-Led AI-Supported Psychosocial Support for Palliative Caregivers
Primary caregivers of palliative care patients assume responsibility for meeting the patient's needs, monitoring symptoms, maintaining care practices, and managing changing needs.
- Trial name
- NCT07799389
- Testing
- Nurse-Led, Generative AI-Supported Individualized Psychosocial Support Program, Routine Care and Information
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Kastamonu University
Palliative Care, Cancer
Mobile Health Application for Family Caregivers in Home Palliative Care
Family caregivers play a central role in providing daily care for patients receiving home palliative care. However, caregiving responsibilities may lead to increased burden, stress, and difficulties in symptom management and care…
- Conditions
- Palliative Care, Cancer, Caregiver
- Trial name
- CARE-Mobile (NCT07654998)
- Testing
- Mobile Health Application
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kutahya Health Sciences University
Aging, Preventive Care
Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2
This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to structured Annual Wellness Visits (AWVs) to improve patient and…
- Conditions
- Aging, Preventive Care, Multimorbidity, Palliative Care
- Trial name
- SPIRE2 (NCT07166861)
- Testing
- Annual Wellness Visit, Annual Wellness Visits + Geriatric Resources and Assessment for the Care of Elders (AWV + GRACE)
- Where
- 4 sites in United States
- Volunteers
- 7,140 people
- Sponsor
- Massachusetts General Hospital
Pediatric Cancer, Palliative Care
Integration of Palliative Care in Pediatric Onco-hematology
PALONCOPED is a multicentre, interregional, observational and qualitative study aiming to better understand the early integration of palliative care in children with cancer.
- Trial name
- PALONCOPED (NCT07838168)
- Testing
- PALONCOPED semi-structured interview
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Intractable Pain, Palliative Care
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
Background: Cancer-induced bone pain (CIBP) is common in people with cancer. Bone cancer can also lead to anxiety, depression, and reduced mobility and quality of life.
- Trial name
- NCT02522611
- Testing
- Resiniferatoxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neoplasms, Palliative Care
Effectiveness and Implementation of 'Supportive and Palliative Care Review Kit in Locations Everywhere'
Advanced cancer patients often experience significant physical and emotional symptoms, which can lead to frequent hospital visits and reduced quality of life.
- Trial name
- SPARKLE-2 (NCT07745816)
- Testing
- SPARKLE-2
- Where
- 2 sites in Singapore
- Volunteers
- 300 people
- Sponsor
- National Cancer Centre, Singapore
Deprescribing, Palliative Care
DEprescribing: Perceptions of PAtients Living With Advanced Cancer
Polymedication in palliative oncology care is a real public health problem. This phenomenon has been shown to increase the risk of iatrogenesis, reduce patients' quality of life and increase healthcare costs.
- Conditions
- Deprescribing, Palliative Care, Oncology
- Trial name
- DEPAL (NCT06193083)
- Testing
- Semi-directed individual interviews, The self-administered questionnaires, rPATD and BMQ, The self-administered FCCHL (Functional, Communicative and Critical Health Literacy) / HLS14 (14-item health literacy scale)
- Where
- 8 sites in France
- Volunteers
- 325 people
- Sponsor
- Nantes University Hospital
Cancer, Palliative Care
Music Therapy Program for Patients in Palliative Care (MUSPAL360)
Hospitalized patients with advanced cancer often experience a heavy burden of physical, emotional, and spiritual symptoms that affect their quality of life.
- Trial name
- NCT07831148
- Testing
- Music Therapy with Virtual Reality (Session 1), Significant Song Choice (Session 2), Biographical Musical Legacy (Session 3)
- Volunteers
- 40 people
- Sponsor
- Austral University, Argentina
Music Therapy, Palliative Care
Evaluation of the Effectiveness of Music Therapy on Anxiety Levels in Patients With Advanced Cancer Hospitalized in a Palliative Care Unit
A music therapy intervention can be either receptive or active. In both cases, somatic effects have been observed, with a direct impact on respiratory, cardiac and hemodynamic parameters, as well as psychological effects…
- Conditions
- Music Therapy, Palliative Care, Cancer, Anxiety
- Trial name
- CessataEl'ansi (NCT07806435)
- Testing
- depression management, Kigonki, questionnaire
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Oral Mucosal Integrity, Palliative Care
Oral Care Interventions in PEG-Fed Palliative Care Patients
This pilot randomized controlled trial will compare three oral care interventions in adult palliative care patients who receive enteral nutrition through a percutaneous endoscopic gastrostomy (PEG) tube.
- Conditions
- Oral Mucosal Integrity, Palliative Care, PEG Feeding
- Trial name
- PEG-ORAL (NCT07792473)
- Testing
- Ankaferd Hemostat, Benzydamine Hydrochloride 0.15% w/v oromucosal solution, Combined Oral Care Solution
- Volunteers
- 60 people
- Sponsor
- University of Yalova
Palliative Care, Advanced Cancer
Coaching in Palliative Surgical Oncology
This study aims to evaluate the effectiveness of a serious illness coaching intervention (CONCORD) in improving quality of serious illness conversation (SIC), treatment decision-making, goal-concordant care delivery and quality…
- Trial name
- NCT07789093
- Testing
- CONCORD coaching intervention
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- Singapore General Hospital
Diabetic Foot Ulcer (DFU), Palliative Care
The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care
The ProActive study aims to investigate the feasibility of integrating a proactive palliative care approach into routine care for people with diabetic foot ulcers (DFU).
- Conditions
- Diabetic Foot Ulcer (DFU), Palliative Care, Advance Care Planning
- Trial name
- NCT07781111
- Volunteers
- 484 people
- Sponsor
- Ulla Riis Madsen
Cancer Pain, Cancer Palliative Care
Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management
The investigators investigate the efficacy of non-opioid analgesics compared to placebo together with opioid therapy for cancer pain management.
- Trial name
- NoDoubt (NCT07682558)
- Testing
- Metamizole, Ibuprofen
- Where
- Switzerland
- Volunteers
- 318 people
- Sponsor
- University Hospital, Basel, Switzerland
Palliative Care, Primary Palliative Care
Primary Palliative Care - a Feasibility Cluster Trial
This feasibility cluster-controlled randomized trial (RCT) evaluates a complex intervention for the delivery of primary palliative care in Family Health Units (FHUs).
- Conditions
- Palliative Care, Primary Palliative Care, Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- PrimPal (NCT07737899)
- Testing
- Primary Palliative Care Complex Intervention (PrimPal)
- Where
- 2 sites in Portugal
- Volunteers
- 30 people
- Sponsor
- University of Coimbra
Cancer, Palliative Care
Yunzhi Essence to Improve the Quality of Life of Patients With Advanced Stage of Cancer
A randomized, double-blinded, placebo-controlled clinical trial using a Chinese Medicine 'Coriolus Versicolor for improving the quality of life of patients with advanced-stage cancer.
- Trial name
- NCT05754801
- Testing
- Yunzhi Essence
- Where
- Hong Kong
- Volunteers
- 172 people
- Sponsor
- Chinese University of Hong Kong
Communication About Intimacy Needs in Hospice and Palliative Care
IN-TALK: Co-producing a Hospice Intimacy Support Toolkit in England
People receiving hospice care may experience concerns about intimacy, closeness and physical affection that can affect their quality of life and wellbeing.
- Trial name
- IN-TALK (NCT07737145)
- Testing
- Experience-Based Co-Design (EBCD) workshops
- Volunteers
- 794 people, healthy volunteers welcome
- Sponsor
- Dorothy House Hospice
Critical Illness, Palliative Care
Improving Needs Among Older Adults
Millions of older adults receive care in intensive care units (ICUs) annually. However, the quality and accessibility of ICU-based palliative care is highly variable across hospitals and clinicians, due in part to specialists'…
- Conditions
- Critical Illness, Palliative Care, Older Adults, Informal Caregivers
- Trial name
- ICUconnect 2 (NCT06588556)
- Testing
- ICUconnect, Usual care
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Duke University
Palliative Therapy, Implementation Science
Clinical Surveillance Tool to Screen for Unmet Palliative Needs Among Patients in the Final Year of Life
One of the most important obstacles to improving end-of-life care is the inability of clinicians to reliably identify those who are approaching the end-of-life.
- Conditions
- Palliative Therapy, Implementation Science, Screening, Terminal Care
- Trial name
- HOMR (NCT04171830)
- Testing
- modified Hospital One-year Mortality Risk (mHOMR)
- Where
- 13 sites in Canada
- Volunteers
- 3,536 people
- Sponsor
- Ottawa Hospital Research Institute