Clinical trials: Pain Threshold
Trigger Points, Myofascial, Myofascial Trigger Points
Dose Response Effects of Cervical Spinal Manipulative Therapy (SMT) on Pressure Sensitivity of Myofascial Trigger Points
Specific Aim 1: To determine if the effect of cervical spinal manipulation on the pressure pain thresholds in a myofascial trigger point in the infraspinatus muscle can be enhanced and/or extended after a second cervical spine…
- Conditions
- Trigger Points, Myofascial, Myofascial Trigger Points, Myofascial Pain Syndrome
- Trial name
- NCT01418170
- Testing
- cervical spinal manipulative therapy
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Canadian Memorial Chiropractic College
Low Testosterone, Hypogonadism
Testosterone and Pain Sensitivity
This research is being done to see whether testosterone replacement in men who take opioid-based pain medications and have low testosterone levels will show improvement in pain tolerance, pain perception and quality of life.
- Conditions
- Low Testosterone, Hypogonadism, Pain
- Trial name
- NCT01689896
- Testing
- Testosterone Gel
- Where
- United States
- Sponsor
- Johns Hopkins University
Fibromyalgia
Effectiveness of Electro Neuro Adaptive Regulator in Patients With Fibromyalgia
Background: There is evidence linking conditioned pain modulation (CPM) deficiency with musculoskeletal pain syndromes such as fibromyalgia, Evidence shows that different physical therapies could activation situations of chronic…
- Trial name
- SCENAR (NCT03882567)
- Testing
- Electro Neuro adaptative Regulator
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad Rey Juan Carlos
Sleep Apnea, Chronic Pain Syndrome
Sleep and Pain Sensitivity
This project will assess patients with diagnosed obstructive sleep apnea, to investigate the impact of poor sleep on central pain mechanisms.
- Trial name
- NCT04246294
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Myofascial Pain of Upper Trapezius Muscle
The Efficacy of Thread Embedding Acupuncture on Pain Score, Neck Disability Index, and Pressure Pain Threshold for Myofascial Pain Therapy in the Upper Trapezius Muscle
Myofascial pain is characterized by myofascial trigger points, considered as a major cause of neck and shoulder pain in the working population.
- Trial name
- NCT05987683
- Where
- 2 sites in Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia
Neuropathic Pain, Complex Regional Pain Syndromes (CRPS)
Sub-threshold DRG Stimulation vs Sham in Established Responders
The goal of this clinical trial is to learn if sub-threshold dorsal root ganglion (DRG) stimulation provides pain relief beyond placebo in adults with chronic neuropathic pain who already have an implanted DRG stimulator.
- Conditions
- Neuropathic Pain, Complex Regional Pain Syndromes (CRPS), Causalgia, Chronic Pain
- Trial name
- DRG-SHAM (NCT07170722)
- Testing
- Subtreshhold DRG-S
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Umeå University
Manual Lymphatic Drainage Effects
Manual Lymphatic Drainage for Pain, Muscle Strength, and Sensation
To evaluate the acute effect of MLD on pressure pain threshold (PPT), pain tolerance, tactile sensation, and muscle strength in healthy young adults. healthy young adults were included in the study.
- Trial name
- NCT06139445
- Testing
- Manual Lymphatic Drainage, Plasebo Group
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Hyperalgesia, Pain Insensitivity, Congenital
The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures
The purpose of this study is to evaluate the correlation between β-endorphin levels in blood plasma and saliva in healthy participants with different pain sensitivity and in those with acute pain in oral and maxillofacial region.
- Trial name
- NCT03164161
- Testing
- Cold pressor test, β-endorphins evaluation in saliva, β-endorphins evaluation in blood plasma
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Analgesia Disorder, Pain
Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects.
Pain exerts a tremendous cost in healthy care, rehabilitation and lost productivity. It is is associated with a wide range of diseases and their social consequences is a public health problem.
- Trial name
- NCT02195271
- Testing
- Transcranial Direct Current Stimulation (tDCS), Melatonin
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Temporomandibular Disorder (TMD), Pain Threshold
Cervical Muscle Endurance and Pressure Pain Threshold in University Students With TMD: A Case-Control Study
Aim: This study aims to compare the static endurance of cervical region muscles, pressure pain thresholds of selected muscles of the stomatognathic system, and postural characteristics in young adults with and without…
- Trial name
- TMED-CME-PPT (NCT07407127)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Migraine
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine
This study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine.
- Trial name
- NCT07143461
- Testing
- Prayer Condition, Reading Condition
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dry Needling, Shoulder Pain
Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity in Individuals with Shoulder Pain
Shoulder pain is one of the most common reasons people consult with their primary health care provider, and 40-50% of these patients with shoulder pain continued to complain of persistent symptoms after 6 to 12 months.
- Trial name
- NCT05596240
- Testing
- Dry Needling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Woman's University
Fibromyalgia Syndrome
Auricular Acupuncture for Autonomic Balance and Pain in Fibromyalgia
This longitudinal study evaluates the effects of semi-permanent auricular acupuncture on the Autonomic Nervous System (ANS) activity and pressure pain threshold in adult female patients (aged 35-64) diagnosed with Fibromyalgia…
- Trial name
- NCT07641374
- Testing
- The needles will be applied to specific auricular points: Point Zero, Shen Men, Thalamus, and Master Cerebral Point.
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Italian Association for the Research and the Scientific Update
High-functioning Autism
Pain in Autism Spectrum Disorder
The proposed project will be first performed on individuals with HF-ASD with their expected heterogeneity and healthy control (HC) subjects in order to explore the pain processing and modulation mechanisms underlying the pain…
- Trial name
- NCT03413241
- Where
- Israel
- Volunteers
- 183 people
- Sponsor
- Rambam Health Care Campus
Anthropometrics: Height and Weight, Isometric Standing and Seated Plantarflexion
Collagen Protein Versus Placebo on Muscle Recovery
This study is focused on exploring the gap in the literature by comparing the effects of collagen protein versus placebo supplementation on the musculotendinous unit following muscle damaging protocol.
- Conditions
- Anthropometrics: Height and Weight, Isometric Standing and Seated Plantarflexion, Calf Muscle Thickness, Achilles Tendon Length and Thickness
- Trial name
- NCT06465407
- Testing
- Collagen, Maltodextrin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Transcutaneous Electrical Nerve Stimulation
The Effect of Frequency Modulation in TENS on Habituation and Pain Threshold
Purpose The purpose of this study is to determine whether application of Transcutaneous Electrical Nerve Stimulation (TENS) is effective on habituation to electrical current whether delivered at a fixed frequency of 100 Hz or at…
- Trial name
- NCT03198377
- Testing
- TENS: Randomized frequency modulation, TENS: Scan 6/6 of frequency modulation, TENS: Fixed frequency
- Where
- Spain
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Gastrointestinal Diseases, Autonomic Nervous System Disease
Relationship of Cervical Region Tension With Vagal Function
The increase in the tension of the soft tissues around a nerve restricts the movement, affects the function of the nerve, and makes the nerve vulnerable to entrapment.
- Trial name
- NCT05325879
- Testing
- VAGUS-NDT
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pain, Physical Activity
Influence of Expectations on Change in Pain Perception After a 3 Min Wallsquat Exercise.
The purpose of this study is to investigate how expectations induced by information given prior to exercise influence the magnitude of exercise-induced hypoalgesia after a 3 min wallsquat exercise in healthy subjects.
- Trial name
- NCT03678662
- Testing
- Hypoalgesia expectation, Hyperalgesia expectation, Neutral
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital