Clinical trials: Pain Reduction
Dental Pulp Necrosis
Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth
The aim of this study is to compare the effect of antimicrobial-corticosteroid mixture and cryotherapy as final root canal irrigating solutions on post-instrumentation pain in single-canal teeth with necrotic pulps.
- Trial name
- MIXCRYO (NCT05739682)
- Testing
- Local anaesthetic injection of 4% articaine with 1:100000 epinephrine, Tooth isolation, Access cavity preparation
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Pain Management, Local Anaesthesia
Effectiveness of DentalVibe in Reducing Injection Pain and Anxiety During Local Anaesthesia in Children
The aim of this study is to determine the effectiveness of DentalVibe (DV) in reducing injection pain and anxiety associated with local anaesthesia in paediatric patients.
- Trial name
- NCT03445182
- Testing
- Local anaesthesia with conventional syringe, Local anaesthesia with conventional syringe + Dentalvibe
- Where
- Bulgaria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Operative Time, Grip Strength
Safety Study of Surgical Technique to Treat Acute Dorsal Trans-Scaphoid Perilunate Dislocations
The purpose of this study is to determine a surgical technique is effective in the treatment of acute dorsal trans-scaphoid perilunate dislocations.
- Conditions
- Operative Time, Grip Strength, Pain, Functional Status
- Trial name
- ADTPD (NCT00738127)
- Testing
- Open reduction and internal fixation
- Where
- China
- Volunteers
- 801 people
- Sponsor
- The Second Hospital of Qinhuangdao
Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema
Cool vs Room-temperature Artificial Tears
Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort.
- Conditions
- Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye, Cystoid Macular Edema
- Trial name
- NCT05832996
- Testing
- Refresh Plus Preservative-free Lubricant Eye Drops
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Knee Osteoarthritis
Virtual Reality and Older Adult Knee OA
At the Brigham and Women's Hospital (BWH) Pain Management Center (PMC), knee OA is one of the most common conditions causing older adults to experience chronic pain.
- Trial name
- NCT04951661
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Tufts University
Intracanal Medication, Bromelain
Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars
the aim of the study is to compare the effect of bromelain vs calcium hydroxide as intracanal medication on intensity of pain and bacterial load in necrotic single lower premolars
- Conditions
- Intracanal Medication, Bromelain, Calcium Hydroxide, Bacterial Load Reduction
- Trial name
- NCT05687760
- Testing
- bromelain, Calcium hydroxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lung Cancer
A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling symptoms, such as the side effects of chemoradiation, when given to…
- Trial name
- NCT01317550
- Testing
- Armodafinil, Minocycline, Questionnaires
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Pain, Opioid Use
Dexmedetomidine and Ketamine in VATS Surgery
Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery.
- Trial name
- NCT03596424
- Testing
- Ketamine Hydrochloride, Dexmedetomidine Hydrochloride, dexmedetomidine Hydrochloride and Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Gynecologic Diseases
Lidocaine Gel During Transrectal Sonography
The aim of this clinical trial is to evaluate the use of topical lidocaine gel in reducing pain associated with transrectal ultrasonography (TRS) in gynecologic field.
- Trial name
- NCT02567838
- Testing
- Lidocaine gel
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kangbuk Samsung Hospital
Intramuscular Injection, Pain
The Effect of Helfer Skin Tap Technique During Tetanus Injection in Pregnant Women
Intramuscular (IM) vaccination administered using the right injection technique is known to cause less pain and injury. Nurses employ different approaches like applying pressure, tapping the skin, cold and hot applications for…
- Trial name
- NCT05761340
- Testing
- Helfer skin tap injection technique, Standard Injection technique
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Pain, Fear
Venous Blood Sampling-Related Pain and Fear
This study is an experimental randomized controlled study conducted to compare the effect of balloon blowing, coughing, and ball squeezing methods applied during venous blood sampling from on pain and fear level in 7-12 year-old…
- Trial name
- NCT03720808
- Testing
- Balloon Blowing, Ball Squeezing, Coughing
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Pain, Chronic, Pain, Postoperative
Efficacy of Pain Neuroscience Education and Pre-anesthetic Assessment in Reducing Levels of Anxiety, Stress and Pain in Patients Undergoing Elective Total Abdominal Hysterectomy (ENAH Study)
Through this quantitative, multivariate factorial experimental parallel randomized clinical trial, the investigators analyzed the effectiveness of pre-anesthetic assessment and pain neuroscience education in reducing anxiety…
- Conditions
- Pain, Chronic, Pain, Postoperative, Anesthesia, Surgery
- Trial name
- NCT05435508
- Testing
- Pain Neuroscience Education, Usual care
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Neurociencia Del Dolor
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Cancer and Chemotherapy Related Anemia, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
Augmented Virtual Reality for Reducing Pain, Stress, Anxiety and Improve Self Efficacy in Adult Cancer Patients Undergoing Chemotherapy in The West Bank
The main purpose of this study is to examine the effect of using AVR on pain, stress, anxiety, and SE among adult cancer patients undergoing chemotherapy in the West Bank hospitals in Palestine.
- Trial name
- AVR-CHEMO (NCT07152938)
- Testing
- AVR Group (Chemotherapy + AVR)
- Where
- 3 sites in Palestinian Territories
- Volunteers
- 150 people
- Sponsor
- Arab American University (Palestine)
Postoperative Pain, Thyroidectomy
Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial
The purpose of this study is to determine whether celecoxib is effective in the treatment postoperative pain after thyroidectomy.
- Conditions
- Postoperative Pain, Thyroidectomy, Cyclooxygenase 2 Inhibitors
- Trial name
- NCT00520338
- Testing
- celecoxib
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Pain Relief During Prostate Biopsy
Combined Intravenous Diazepam, Local Periprostatic Nerve Block for Prostate Biopsy
Prostate biopsy under transrectal ultrasound (TRUS) guidance is considered the procedure of choice for diagnosing prostate cancer.
- Trial name
- NCT02935972
- Testing
- Diazepam, Lidocaine 1%, Diazepam and Lidocaine 1%
- Where
- Egypt
- Volunteers
- 336 people
- Sponsor
- Assiut University
Pain
Aromatherapy for Reducing Labor Pain
Pregnant women who eligible with inclusion criteria are random to two groups. Aromatherapy group will receive the aromatherapy during labor along with standard pain control.
- Trial name
- NCT03098212
- Testing
- Aromatherapy
- Volunteers
- 94 people
- Sponsor
- Chiang Mai University
Phantom Limb Pain, Amputation
TITAN Trial: Reducing Phantom Limb Pain in People with Amputations
The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain.
- Trial name
- TITAN (NCT06167330)
- Testing
- Progressive rehabilitation program, Stimulation devices
- Where
- Australia
- Volunteers
- 208 people
- Sponsor
- Neuroscience Research Australia
Headache, Migraine
Short-term Effectiveness of Transcutaneous Nerve Stimulation in Reducing Migraine Related Pain
The purpose of this study is to evaluate the short-term effectiveness of combined occipital and supraorbital transcutaneous nerve stimulation in reducing migraine related pain.
- Trial name
- NCT02438553
- Testing
- OSTNS Neurostimulator
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Neurolief Ltd.