Clinical trials: Pain Intractable
Cancer-related Problem/Condition
Combined Fluoroscopy and CT Guided Radiofrequency Ablation of Thoracic Dorsal Root Ganglia in Severe Thoracic Pain
In the current study, extra-guidance other than conventional fluoroscopy - will be integrated to improve the success of the transforaminal approach to the thoracic dorsal root ganglia (DRG).
- Trial name
- NCT03533413
- Testing
- combined CT-fluroscopy, standard fluroscopy
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- National Cancer Institute, Egypt
Neuropathic Pain
A Feasibility Study to Investigate the Dynamic Brain Imaging in Patients Following SCS- DRG
Targeted SCS is a standard and safe interventional pain procedure that is offered to patients with intractable neuropathic pain for their symptomatic relief.
- Trial name
- NCT04508127
- Testing
- Spinal cord stimulation
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Chronic Refractory Plantar Fasciopathy
Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy
Chronic refractory plantar fasciopathy is a common musculoskeletal condition that can cause persistent heel pain and functional limitations despite conservative treatment.
- Trial name
- NCT07654660
- Testing
- Multimodal Conservative Intervention, Endoscopic Plantar Fascial Release
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Europea de Valencia
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04454424
- Testing
- BAY1817080, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Bayer
Refractory Angina
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
To demonstrate the safety and effectiveness of the Shockwave Reducer for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence…
- Trial name
- COSIRA-II (NCT05102019)
- Testing
- Arm 1: treatment with Shockwave Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
- Where
- 97 sites in United States, Canada and 1 more
- Volunteers
- 380 people
- Sponsor
- Shockwave Medical, Inc.
FBSS
Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain
The aim of this study is to evaluate the efficacy of oral administration of nabilone or THC/CBD administration in combination with spinal cord stimulation (SCS) in FBSS patients refractory to other available therapeutic…
- Trial name
- NCT03210766
- Testing
- Nabilone, THC/CBD
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Multi-Organ Disorder
Pulsed RF Neuromodulation and Leukocyte-Rich PRP for Refractory Low Back Pain
This clinical trial aims to check the safety and efficacy profile of pulsed radiofrequency (RF) neuromodulation combined with leukocyte-rich platelet-rich plasma (PRP) injections for the treatment of refractory low back pain due…
- Trial name
- Multifidus (NCT06524531)
- Testing
- Pulsed RF Neuromodulation, Leukocyte-Rich PRP Injection, Physiotherapy Alone
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Iffat Anwar Medical Complex
Pain, Intractable
Pain Blocking During Drug Administration or Blood Collection With Needles
There is a gating mechanism in the dorsal horn of the spinal cord that acts to facilitate or inhibit transmission of pain signals to the brain. The gate can be closed by mechanical stimuli such as touch and vibration.
- Trial name
- NCT01166906
- Testing
- pain blocking
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Orofacial Pain
Effects of Transcranial Direct Current Stimulation (tDCS) on Patients With Chronic Orofacial Pain
Patients affected by chronic orofacial pain represent an emergent medical problem due to the lack of knowledge on the cause, pathophysiology and psychology of many of these conditions, that belongs to a multifactorial origin.
- Trial name
- NCT01883245
- Testing
- real tDCS
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Bladder Pain Syndrome
Comparative Study Suburothelial and Trigonal Botulinum Toxin A Injection in Treatment of Interstitial Cystitis
There is no consensus of the therapeutic efficacy and safety between suburothelial injection and trigonal injection of botulinum toxin A (BoNT-A) in treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) It is unmet to…
- Trial name
- NCT03076762
- Testing
- intravesical onabotulinumtoxinA injection
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Angina Pectoris, Coronary Disease
Cardiac Rehabilitation for the Treatment of Refractory Angina
The purpose of this study is to determine whether cardiac rehabilitation is a successful treatment for refractory angina, in relation to improvements in cardiovascular risk factors, physical ability, symptomology, quality of life…
- Trial name
- NCT00411359
- Testing
- Cardiac rehabilitation
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- National Heart and Lung Institute
Trigeminal Neuralgia
MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating Trigeminal Neuralgia.
- Trial name
- NCT04579692
- Testing
- ExAblate Transcranial treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Advanced Cancer
Observational Study of Incidence of Breakthrough Cancer Pain and How it is Treated
The purpose of this study is to describe how often advanced cancer patients experience breakthrough pain (BTcP), and to describe how this pain is treated, and how effective these treatments are.
- Trial name
- Break-1 (NCT02069067)
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute, Naples
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Endometriosis, Chronic Pelvic Pain Syndrome
Effect of Massage and Hydrotherapy to Improve Well-being and Pain Perception in Endometriosis Patients
The objective is to analyze the short-term effect of a comprehensive HAMMAM experience combining therapeutic hydrotherapy, aromatherapy, music therapy, and Swedish massage on objective parameters and patient-reported outcomes…
- Trial name
- NCT06506708
- Testing
- Hydrotherapy + massage
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad de Granada
Plantar Fascitis
Percutaneous Needle Tenotomy Associated With Platelet-rich Plasma Injection Platelet-rich Plasma in the Treatment of Refractory Plantar Fasciitis: a Pilot Study of the Effect on Pain and Tolerance
There are various treatments for plantar fasciitis, including physical therapy, orthopedic inserts or steroid infiltrations. However, it is estimated that about 20% of patients do not respond to first-line treatment [Rompe…
- Trial name
- ANTILOPE (NCT05622279)
- Testing
- Percutaneous tenotomy + PRP
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Nantes University Hospital
Neoplasms, Bone Tissue, Pain, Intractable
Study of the Impact of the Femoral Implant "Y-strut" on Lytic Bone Metastases of the Femoral Neck (WAZA-ARY)
Bone metastases appear in many cancers. They are associated with severe pain that is refractory to standard treatment. Improving the quality of life and better pain relief is therefore an essential goal of the treatment of…
- Conditions
- Neoplasms, Bone Tissue, Pain, Intractable, Hip Fractures
- Trial name
- WAZA-ARY (NCT03887494)
- Testing
- Implantation
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Refractory Angina Pectoris, Ischemic Heart Disease
Cardiac Shock Wave Treatment in Patients With Reduced Coronary Flow Reserve
The purpose of the study is to assess the feasibility of Cardiac Shock Wave Treatment in patients with anginal chest pain and evidence of abnormal myocardial perfusion under stress in the absence of significant stenoses of the…
- Conditions
- Refractory Angina Pectoris, Ischemic Heart Disease, Coronary Artery Disease
- Trial name
- NCT03438500
- Testing
- Cardiac Extracorporeal Shockwave Therapy (Modulith SLC)
- Where
- Germany
- Sponsor
- Storz Medical AG
Late Complication From Skin Graft, Infection of Skin Donor Site
Clinical Study on Silk Sericin Wound Dressing for Split-thickness Skin Graft Donor Sites Treatment
1. Silk sericin wound dressing may reduce time for complete epithelialisation of split-thickness skin graft donor sites compared to Bactigras®. 2.
- Conditions
- Late Complication From Skin Graft, Infection of Skin Donor Site, Impaired Wound Healing, Pain, Intractable
- Trial name
- NCT01539980
- Testing
- Sericin scaffold
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Pain, Intractable, Pain, Chronic
Comparison of DTM™ SCS Therapy Combined With Conventional Medical Management (CMM) to CMM Alone in the Treatment of Intractable Back Pain Subjects Without Previous History of Lumbar Spine Surgery
The purpose of this investigational study is to document the safety, clinical effectiveness and health economic analytics of DTM™ SCS programming delivered through the Intellis™ neurostimulator in subjects with chronic…
- Trial name
- NCT06442410
- Testing
- DTM™ spinal cord stimulation therapy delivered via Intellis™ neurostimulator system, Conventional Medical Management (CMM)
- Where
- 12 sites in Belgium, Germany and 2 more
- Volunteers
- 115 people
- Sponsor
- MedtronicNeuro