Clinical trials: Pacing Therapy
Pacemaker DDD, His Bundle Pacing
Pacing to Maintain Physiologic Ventricular Activation
Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest…
- Conditions
- Pacemaker DDD, His Bundle Pacing, LBB Area Pacing, Pacing-Induced Cardiomyopathy
- Trial name
- Pace-Conduct (NCT04416958)
- Testing
- cardiac implantable electronic device (CIED) implantation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum-Fuerth
Heart Failure
The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy With MultiPoint Pacing
The purpose of this study is to evaluate the application of Negative AV Hysteresis (NAVH) to improve electrical synchrony in MultiPoint Pacing (MPP) Cardiac Resynchronization Therapy (CRT) patients.
- Trial name
- NCT02782598
- Testing
- CRT+NAVH
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Abbott Medical Devices
Conduction System Pacing, Pacing Therapy
Solutions to the Challenges of Conduction System Pacing
Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times.
- Trial name
- CSA (NCT07009834)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Stroke, Traumatic Brain Injury
Clinical Validation of Self-Pacing Algorithms on Step Length Symmetry in Hemiplegic Populations
The goal of this clinical trial is to evaluate the efficacy of self-pacing algorithms in promoting step-length equalization in people with weakness on one side of the body.
- Trial name
- NCT07759063
- Testing
- Walking on self-pacing treadmill, Walking on fixed-pacing treadmill
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Quality Living, Inc.
Bradycardia, Left Bundle Branch Area Pacing
Left Bundle Branch Area Pacing (LBBAP) Monitoring Assistant: Evaluation of Portable ECG Solution
To evaluate the capability to monitor LBB success criteria with the use of a Smart ECG system (ECG monitor, 12 leads ECG cable, ECG viewer software ) during a cardiac device implantation involving the placement of a pacing lead…
- Conditions
- Bradycardia, Left Bundle Branch Area Pacing, Cardiac Resynchronisation Therapy (CRT), ECG
- Trial name
- LBBOT (NCT07254013)
- Testing
- LBBAP implant
- Where
- 4 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Heart Failure
Triple-site Biventricular Stimulation in the Optimization of CRT
Cardiac resynchronization is a recommended therapy for patients with advanced heart failure, under optimized medical treatment with reduced left ventricular ejection fraction and prolonged QRS, nevertheless, still 30% of the…
- Trial name
- TRIUMPH-CRT (NCT02350842)
- Testing
- triple-site biventricular pacing with peri-operative echo guidance, standard biventricular pacing
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Atrial Arrhythmia, Atrial Tachycardia
ATrial Tachycardia PAcing Therapy in Congenital Heart
Congenital heart disease (CHD) affects approximately 1% of newborns in the US, with 25% of those affected having critical conditions requiring open heart surgery within one year of birth.
- Conditions
- Atrial Arrhythmia, Atrial Tachycardia, Congenital Heart Disease, Pacemaker Re-Entrant Tachycardia
- Trial name
- AT-PATCH (NCT03209583)
- Testing
- Medtronic
- Where
- 15 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Ian Law
Cardiac Electrophysiology
Transvenous Lead Removal Post-Market Clinical Study
This prospective, multicenter, post-market clinical study was designed to evaluate the outcomes of lead extraction of cardiovascular implantable electronic devices (CIED) using Cook catheter and lead extraction devices for any…
- Trial name
- NCT03688412
- Testing
- Cook lead extraction devices
- Where
- 9 sites in United States, Germany and 2 more
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Cook Research Incorporated
Heart Failure, Cardiac Resynchronization Therapy
Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)
The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width…
- Trial name
- NCT01179997
- Testing
- Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves, Electrocardiographic optimization of the interventricular pacing delay according to QRS width
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital Clinic of Barcelona
Left Ventricular Dysfunction, Heart Failure
Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure
To compare a surgical approach of LV lead placement for BIV pacing with the conventional transvenous approach by assessment of differences on the effects on cardiac perfusion and relate this to the clinical cardiac function.
- Trial name
- CONTRACT (NCT00551681)
- Testing
- biventricular pacemaker with epicardial left ventricular lead, transvenous left ventricular lead placement
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- R&D Cardiologie
Heart Failure, Systolic
Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients
Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical…
- Trial name
- METEOR-CRT (NCT04083690)
- Testing
- Reprogramming of CRT Device Settings to Optimal Electrical Synchrony
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Allina Health System
Heart Failure
Assessment of Efficacies of Cardiac Resynchronization Therapies (CRT-P/D) for Heart Failure Patients in China
The ADOPT study is a prospective, nested case-controlled and open label clinical trial. About 40 centers across China participate in this study with a planned 800 Chinese cases enrollment.
- Trial name
- ADOPT (NCT01018667)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xijing Hospital
Multiple Sclerosis
Pacing Activity Self-management for Patients With Multiple Sclerosis
Given the lack of evidence in support of pacing self-management for patients with musltiple sclerosis (MS), it is examined whether physical behavior and health status of patients with MS improve in response to a pacing…
- Trial name
- NCT01512329
- Testing
- pacing, relaxation
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- Vrije Universiteit Brussel
Atrial Fibrillation, Congestive Heart Failure
Investigational Device Exemption (IDE) Study for the Approval of Closed Loop Stimulation (CLS) and Cardiac Resyncronization Pacing Therapies (CRT) for the Treatment of Atrial Fibrillation (AF) With Ablate and Pace
The purpose of this study is to demonstrate the safety and effectiveness of biventricular pacing over conventional right ventricular pacing in patients with persistent or permanent, symptomatic atrial fibrillation undergoing…
- Trial name
- AVAIL (NCT00356057)
- Testing
- Protos DR/CLS and Stratos LV CRT pacemakers
- Where
- 10 sites in United States
- Volunteers
- 153 people
- Sponsor
- Biotronik, Inc.
Cardiac Rhythm Disorder
3T MRI CIED Post-Approval Study
The purpose of this study is to evaluate product performance of Magnetic Resonance (MR) Conditional Cardiac Implantable Electronic Devices (CIED) following 3 tesla (3T) MRI exposure.
- Trial name
- NCT02969395
- Where
- 204 sites in United States, Belgium and 20 more
- Volunteers
- 41 people
- Sponsor
- Medtronic
Atrial Fibrillation
Atrial Fibrillation: Canadian Atrial Fibrillation Evaluation (CAFE) Study -
To evaluate whether atrial fibrillation (AF) therapies in Guidant Pulsar Max II or Insignia Plus DR have an effect on the occurance of AF in patients with no prior history of AF
- Trial name
- CAFE (NCT00848445)
- Testing
- Guidant Pulsar Max II or Insignia Plus DR, Atrial pacing preference turned on or off
- Volunteers
- 270 people
- Sponsor
- Boston Scientific Corporation
Cardiac Pacing, Artificial, Cardiac Resynchronization Therapy
Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing
The aims are to compare Direct His Bundle Pacing (DHBP) with biventricular pacing (BiV) in terms of electrical resynchronization using electrocardiographic imaging (ECGI) and also in terms of acute hemodynamical effect using…
- Conditions
- Cardiac Pacing, Artificial, Cardiac Resynchronization Therapy, Direct His Bundle Pacing
- Trial name
- NCT03452462
- Testing
- Pacing
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- University Hospital, Geneva
Cardiac Resynchronization Therapy, Heart Failure
Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).
- Trial name
- CONSYST-CRT II (NCT06105580)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Hospital Clinic of Barcelona
Cardiac Resynchronization Therapy, Heart Failure
Optimal Cardiac Resynchronization Therapy Pacing Rate
The optimal pacing rate during cardiac resynchronization therapy (CRT) is not known. Investigators investigate the impact of changing basal pacing frequencies on autonomic nerve function, cardiopulmonary exercise capacity and…
- Conditions
- Cardiac Resynchronization Therapy, Heart Failure, Bi-ventricular Pacing, Sympathetic Activity
- Trial name
- NCT02258061
- Testing
- DDD-80, DDD-60
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Right Bundle-Branch Block, Heart Failure
His-Bundle Corrective Pacing in Heart Failure
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs.
- Conditions
- Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
- Trial name
- HIS-CRT (NCT05265520)
- Testing
- His-CRT implantation, BIV-CRT implantation
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester