Clinical trials: PERIODONTAL DISEASE
Type 2 Diabetes Mellitus, Periodontitis
Integrated Diabetes and Oral Health Care in Oman
Type 2 diabetes mellitus (T2DM) and periodontal (gum) disease are closely related conditions that may negatively affect each other. However, oral health is not routinely integrated into diabetes self-management education.
- Conditions
- Type 2 Diabetes Mellitus, Periodontitis, T2DM, Periodontal Disease
- Trial name
- NCT07809477
- Testing
- Health Belief Model-Based Integrated Diabetes-Oral Health Educational Intervention, Standard Diabetes Education and Routine Care
- Volunteers
- 290 people
- Sponsor
- Oman Ministry of Health
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Parkinson Disease (PD), Periodontitis
Evaluation of the Effects of Levodopa-Benserazide Drug Combination on Periodontal Status in Patients With Parkinson's Disease
The aim of this study is to evaluate the effects of Levodopa-Benserazide drug combination on periodontal status and salivary cytokine levels in patients with Parkinson's disease.
- Conditions
- Parkinson Disease (PD), Periodontitis, Periodontal Diseases
- Trial name
- NCT07405268
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Type 2, Periodontal Disease
Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes
The purpose of this clinical study is to evaluate the effect of a behavioral intervention on the number of preventive and treatment dental claims in a population of people with Type 2 Diabetes.
- Conditions
- Diabetes Type 2, Periodontal Disease, Caries
- Trial name
- NCT07619729
- Testing
- Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Colgate Palmolive
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Periodontal Diseases
Comparative Evaluation of Effect of NSPT With & Without Adjunctive LANAP on OHRQoL: A Randomized Clinical Trial.
This study compared SRP alone and SRP combined with LANAP in 120 patients with chronic periodontitis. Clinical outcomes and oral health-related quality of life (OHRQoL) were assessed before and 12 weeks after treatment.
- Trial name
- LANAP (NCT07798765)
- Testing
- SRP with laser assisted new attachment procedure
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Mahe Nigar
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Periodontitis Stage IV, Periodontitis
Microbiological Modulation Of The Oral-Gut Axis After Treatment With Or Without Systemic Use Of Probiotics In Patients With Periodontitis: A Randomized Controlled Clinical Study.
This study aims to evaluate whether the oral administration of probiotics, in combination with conventional periodontal treatment (deep cleaning of the tooth root surfaces), can improve oral health and influence the relationship…
- Trial name
- NCT07792902
- Testing
- Probiotics Bifidobacterium animalis subsp. lactis HN019
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis, Gingivitis
Evaluation of PTHrP, RANKL, and OPG Levels in Periodontal Health and Diseases
This observational study aims to evaluate the levels of specific biological markers-Parathyroid Hormone-Related Protein (PTHrP), RANKL, and Osteoprotegerin (OPG)-in the gingival crevicular fluid of individuals with different gum…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease
- Trial name
- NCT07793370
- Testing
- Routine periodontal clinical examination and GCF collection
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Bony Defects, Periodontal Disease
Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients
This study aims to assess the effect of chlorhexidine augmented I-PRF together with MINST and I-PRF alone with MINST versus MINST alone in the treatment of stage III periodontitis patients.
- Trial name
- MINST (NCT07791238)
- Testing
- Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2%
- Volunteers
- 63 people
- Sponsor
- Cairo University
Pregnancy, Thyroid Disease Pregnancy
Periodontal Status and Thyroid Markers in Pregnancy
This cross-sectional study aims to evaluate the association between periodontal status and serum thyroid markers among 100 systemically healthy pregnant women aged 18-45 years in the second trimester (13-27 weeks).
- Conditions
- Pregnancy, Thyroid Disease Pregnancy, Periodontal Disease
- Trial name
- NCT07787676
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Crowding, Dental Occlusion, Traumatic
Exploration of the Utility of Dental-dedicated MRI for Dentistry
This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images.
- Conditions
- Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment
- Trial name
- NCT06948162
- Testing
- dental-dedicated MRI (ddMRI)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Gingivitis and Periodontal Diseases
Evaluation of Toothbrush Bristles
The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles. The main questions it aims to answer are the effects of two different bristle types on: how much plaque is on the teeth how…
- Trial name
- NCT07306026
- Testing
- Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Periodontal Disease, Obesity & Overweight
Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy
This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis.
- Trial name
- GLP1-PERIO (NCT07770906)
- Testing
- non-surgical periodontal therapy
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Plaque Induced Gingivitis
Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis
This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients.
- Trial name
- chx oilpulling (NCT07769112)
- Testing
- Chlorhexidine mouthwash (0.12%), coconut oil pulling
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Periodontal Disease; Gingivitis; Dental Plaque; Malocclusion (Post-orthodontic Treatment)
Digital vs Conventional VFR in Post-Orthodontic Retention
This study is comparing two ways of making a retainer, the clear, removable kind worn after braces to see whether the way it's made affects gum health.
- Trial name
- NCT07760935
- Testing
- Digital Vacuum-Formed Retainer, Conventional Vacuum-Formed Retainer
- Volunteers
- 52 people
- Sponsor
- Ziauddin University
Gingivitis, Gingival Diseases
NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery
The aim of this study is to prove that Novosyn Quick and Monosyn Quick are equivalent in early wound healing in adult patients undergoing resective periodontal surgery.
- Conditions
- Gingivitis, Gingival Diseases, Periodontal Diseases
- Trial name
- NOQMOQS (NCT05813236)
- Testing
- Novosyn® in resective periodontal surgery, Monosyn® in resective periodontal surgery
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Aesculap AG
Periodontal Diseases
Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis
Plaque-induced gingivitis is a clinical condition that appears to cause persistent inflammation in gingiva. It is a preliminary cause to periodontitis but it can be inverted to address the risk of periodontitis development.
- Trial name
- NCT06904742
- Testing
- Tea tree oil, Thyme oil hydrosol, LISTERINE ZERO Alcohol Mouthwash COOL MINT
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Altinbas University
Periodontal Disease, Gingivitis and Periodontal Diseases
Hippo Signaling Pathway Proteins in Gingival Crevicular Fluid of Individuals With Periodontal Disease
Periodontal disease is a chronic inflammatory condition of the tooth-supporting tissues in which the host inflammatory response drives the destruction of alveolar bone and periodontal attachment.
- Conditions
- Periodontal Disease, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- BYHN-GCF-HIPPO (NCT07759466)
- Testing
- ELISA Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Inonu University
Periodontal Diseases
Evaluation of Salivary Adseverin, 1-Alpha Defensin and sRANKL Levels of Individuals With Different Periodontal Diseases
: The aim of this study is; detection of Adseverin,1-alpha Defensin,sRANKL(soluble RANKL) levels in saliva samples of periodontally healthy, gingivitis and periodontitis patients and the possible correlation between these values…
- Trial name
- NCT06402877
- Testing
- Saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University