Clinical trials: Oxygen Therapy
Late Effect of Radiation
Hyperbaric Oxygen - a New Treatment Modality in Patients With Radiation Damaged Salivary Gland Tissue
Randomized clinical trial regarding the effect of hyperbaric oxygen on late radiation tissue injury to salivary gland tissue.
- Trial name
- NCT01606644
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Lone Forner
Cirrhosis
Propofol Versus Midazolam for Upper Endoscopy in Cirrhotic Patients
Upper GI endoscopy is often performed in patients with chronic liver disease to screen for esophageal and gastric varices. The purpose of this study is to compare propofol to midazolam for sedation in patients with chronic liver…
- Trial name
- NCT01141036
- Testing
- propofol, Midazolam
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Ziv Hospital
Arteriosclerosis, Coronary
Aquatic and Land Aerobic Training, Cardiorespiratory and Metabolic Variables in Cardiorespiratory Diseases
In the pathophysiological process of coronary artery disease (CAD), are present, autonomic dysfunction and reduced functional capacity.
- Trial name
- NCT02198872
- Testing
- Exercise, Aerobic (Water based), Land Group
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Metodista de Piracicaba
Oxygen Deficiency, COPD Exacerbation
FreeDom: Innovative Strategy for the Management of COPD Exacerbations
The main objective of the study is to assess the "FreeDom" innovative strategy (FreeO2 at Domicile) to reduce hospitalization duration in patients with COPD exacerbation.
- Trial name
- NCT03396172
- Testing
- Control, FreeDom
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Hypoxia, Desaturation of Blood
SpO2 Accuracy Low Saturation Validation of the OxySoftN Sensor
To compare prototype pulse oximeter saturation measurements, during normal to low saturation, to saturation measurements made by a multi-wavelength CO-oximeter, taken from arterial blood samples from healthy human subjects.
- Trial name
- NCT04811963
- Testing
- Non-Invasive Controlled Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Acute Respiratory Distress Syndrome
Long Term Outcome on Brain and Lung of Different Oxygen Strategies in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a serious disease with high mortality. In patients who survive ARDS, respiratory, neurological and motor sequelae are frequent, negatively impacting on the patient's quality of life…
- Trial name
- LTO-BLOXY (NCT03621293)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 259 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diabetic Macular Edema
Change Oxygen Consumption Following Intravitreal Treatment of Lucentis (Ranibizumab) in Eyes With Diabetic Macular Edema
Recent reports suggest that anti-VEGF agents (ranibizumab) may suppress the progression of retinal nonperfusion area. This protective effect would cause the increase of the oxygen consumption in the diabetic retina.
- Trial name
- NCT02329132
- Testing
- Ranibizumab
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Nocturnal Hypoxemia
Evaluation of POC Pulse-dose Demand Oxygen Delivery for Nocturnal Hypoxemia
The aim of this study is to describe the effect of the Inogen Rove 6 Portable Oxygen Concentrator on peripheral oxygen saturation in adults receiving supplemental oxygen at night and examine whether the device can adequately…
- Trial name
- NCT06000332
- Testing
- InogenOne Rove 6 Portable Oxygen Concentrator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Inogen Inc.
Respiratory Distress Syndrome in Premature Infant
Immediate Treatment Outcomes of b-CPAP vs Oxygen Therapy in Preterm Babies Presenting With RDS at KCMC
Bubble - Continuous positive airway pressure (CPAP) has been reported to be effective, cheaper, simpler and more accessible compared to mechanical ventilator and surfactant treatment for preterms with respiratory distress…
- Trial name
- NCT03620448
- Testing
- bCPAP Arm, Oxygen Arm
- Volunteers
- 48 people
- Sponsor
- Kilimanjaro Christian Medical Centre, Tanzania
Mechanical Ventilation Weaning, Spontaneous Breathing Trial
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial…
- Conditions
- Mechanical Ventilation Weaning, Spontaneous Breathing Trial, High Flow Oxygen Therapy
- Trial name
- HFTO-SBT (NCT07864415)
- Testing
- T-piece, HFTO 50, washout, HFTO 70, washout, PSV., T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
- Volunteers
- 30 people
- Sponsor
- Argentinian Intensive Care Society
Lung Neoplasms, Pneumothorax
HFNO Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation
With the continuous strengthening of the concept of rapid rehabilitation, great progress has been made in minimally invasive thoracic surgery, and thoracoscopic surgery has developed rapidly.
- Trial name
- NCT05666908
- Testing
- HFNO
- Volunteers
- 112 people
- Sponsor
- Shenzhen Second People's Hospital
Dementia, Mood
Bright Light Therapy in Older Adults With Moderate to Very Severe Dementia
INTRODUCTION: Bright light therapy (BLT) has demonstrated positive effects on sleep, mood, and behavioral problems in older adults with dementia. However, there is little research in people with advanced stages of dementia.
- Conditions
- Dementia, Mood, Behavior
- Trial name
- BLT-Dementia (NCT04949984)
- Testing
- Bright light therapy
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Universidade da Coruña
Perioperative Fluid Management
Comparison of Perioperative Standard Fluid Management and Goal-Directed Fluid Management
To compare the goal-directed fluid therapy based on the data obtained from the hemodynamic monitoring system, which provides continuous CO, SV and SVV measurements through arterial pressure wave with standard fluid therapy in…
- Trial name
- NCT04728178
- Testing
- Crystalloid solution, Colloid solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Premature Infant, Work of Breathing
Work of Breathing and Kangaroo Mother Care
To compare work of breathing and oxygen saturation before, during, and after kangaroo mother care in preterm very low birth weight (VLBW) infants stable on non-invasive respiratory support.
- Conditions
- Premature Infant, Work of Breathing, Oxygen Saturation
- Trial name
- NCT03683316
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Christiana Care Health Services
Muscle Oxygenation
Evaluation of Muscle Oxygen With MRI
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
- Trial name
- NCT07638384
- Testing
- Compression and Contraction
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Brain Metastases
A Proof-of-principle Study of HBO-SRS for Brain Metastases
Patients with brain metastases who are candidates for treatment with stereotactic radiosurgery (SRS) are potential study participants.
- Trial name
- NCT01850563
- Testing
- Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
COVID-19
Awake Prone Position for Early Hypoxemia in COVID-19
Prone positioning is a well studied and validated treatment for severe acute respiratory distress syndrome (ARDS), however there are no randomized studies on the use of prone positioning in the non-intubated patient.
- Trial name
- APPEX-19 (NCT04344587)
- Testing
- Self-prone position recommendation, Usual care
- Where
- 13 sites in United States, Spain
- Volunteers
- 305 people
- Sponsor
- Boston University
Chronic Obstructive Pulmonary Disease
Evaluation of a Portable Oxygen Concentrator During Ambulation for Patients Who Require Supplemental Oxygen (POC-LEAN)
Prospective randomized study with a cross-over design. Mobi™ is a relatively new POC in the market and thus it is valuable to collect data from COPD patients using supplemental oxygen, and their use on Mobi™.
- Trial name
- NCT04107493
- Testing
- Portable Oxygen Cylinder, Mobi
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- ResMed
Sleep Apnea
Validation of Sleep Apnea Diagnosis Device
Obstructive sleep apnea (OSA) is common and largely underdiagnosed disease. The standard method for the diagnosis of OSA is a complete night polysomnography (PSG). Simple methods for OSA diagnosis are necessary.
- Trial name
- NCT03526133
- Testing
- Polysomnography (PSG) and wireless sensor Oxistar
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Retinal Oxygenation, Retinal Blood Flow
Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation
Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process…
- Trial name
- NCT01692821
- Testing
- 100% oxygen breathing, 15% oxygen in N2 breathing, 12% oxygen in N2 breathing
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
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