Clinical trials: Overweight , Obesity
Overweight, Obesity
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo).
- Trial name
- OASIS 5 (NCT07770841)
- Testing
- Semaglutide
- Where
- 62 sites in United States, Belgium and 8 more
- Volunteers
- 450 people
- Sponsor
- Novo Nordisk A/S
Body Weight, Obesity
Meta-analysis of the Nordic Dietary Pattern on Cardiometabolic Risk and Cardiovascular Outcomes
The Nordic Diet is a dietary pattern rich in traditional Nordic foods, including berries, grains, and fatty fish common in northern Europe.
- Conditions
- Body Weight, Obesity, Overweight and Obesity, Obesity, Abdominal
- Trial name
- NCT04094194
- Testing
- Nordic diet
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Prostate Cancer, Obesity
Exercise, Prostate Cancer and Circulating Tumour Cells
Obesity, known to be associated with a pro-inflammatory, pro-thrombotic humoral milieu, confers a worse prognosis in prostate cancer (PrCa). Circulating tumour cells (CTCs) are identified in the blood in advanced cancer.
- Trial name
- ExPeCT (NCT02453139)
- Testing
- Exercise
- Where
- 6 sites in Ireland, United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Dublin, Trinity College
Obesity, Non-obese Controls
NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity
We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).
- Trial name
- NCT01727245
- Testing
- Obese, Control group
- Where
- 3 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Karolinska Institutet
Atrial Fibrillation, Heart Failure
Empagliflozin and Atrial Fibrillation Treatment
The primary purpose of this trial is to evaluate the impact of empagliflozin, as compared with placebo, in patients with diabetes mellitus or overweight, heart failure and atrial fibrillation.
- Conditions
- Atrial Fibrillation, Heart Failure, Obesity, Diabetes Mellitus
- Trial name
- EMPA-AF (NCT04583813)
- Testing
- Empagliflozin
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Miulli General Hospital
Obesity
Evaluation of Endothelial and Vascular Functions in Obese Patients (FUENVASOB)
The primary objective of the present study will be to evaluate, in obese patients, the blood flow response in the femoral artery in response to passive limb movements, taken as a biomarker of a possible limitation of the…
- Trial name
- FUENVASOB (NCT05778513)
- Testing
- Passive knee flexion-extension + Cycle ergometer exercise + 3-week body weight reduction program, Passive knee flexion-extension + Cycle ergometer exercise
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Istituto Auxologico Italiano
Obesity and Psoriasis
The Effect of Ketogenic Diet Versus Mediterranean Diet in Patients With Obesity and Psoriatic Arthritis
The aim of our study is to compare the effectiveness of Mediterranean diet (MD) with the isocaloric Ketogenic diet (KD) on clinical and biochemical markers of inflammation in patients with obesity, psoriasis (PSO) and psoriatic…
- Trial name
- NCT06164860
- Testing
- Meditteranean Diet, Ketogenic Diet
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- Attikon Hospital
Obesity, Dyslipidemia
Reduction of Sweetened Beverages and Intrahepatic Fat
The study will enroll 68 overweight male and female subjects with a high (> 2 3dl-can soda/day) consumption of sweetened beverage per day.
- Conditions
- Obesity, Dyslipidemia, Metabolic Syndrome
- Trial name
- REDUCS (NCT01394380)
- Testing
- artificially sweetened sodas
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University of Lausanne
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Visceral Obesity, Insulin Resistance
The Effects of Water-only Fasting and Refeeding on Body Composition
This observational pilot study will assess the effects of water-only fasting on body composition and insulin resistance
- Trial name
- NCT04514146
- Testing
- Water-only fasting
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- TrueNorth Health Foundation
Weight Management
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
This master study protocol, Study D7260C00015, covers 2 independent, pivotal studies, Study 1 and Study 2. Each study is a global, randomized, double-blind, parallel-group, multicenter, Phase III study to assess the efficacy and…
- Trial name
- Embold (NCT07667803)
- Testing
- Elecoglipron
- Where
- 325 sites in United States, Argentina and 17 more
- Volunteers
- 4,500 people
- Sponsor
- AstraZeneca
Obesity
A Pilot Trial of Nabilone for the Treatment of Obesity
Obesity is a serious health problem which increases the likelihood of developing other life-changing medical conditions. Despite increasing knowledge about the neural and metabolic basis of obesity, the development of effective…
- Trial name
- NCT04801641
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Preeclampsia, Postpartum Period
The PreEclampsia Postpartum Prevention Trial
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy.
- Conditions
- Preeclampsia, Postpartum Period, Hypertension, Cardiovascular Diseases
- Trial name
- PEPP (NCT07199283)
- Testing
- Bundle Intervention
- Where
- 2 sites in Sweden
- Volunteers
- 356 people
- Sponsor
- Karolinska Institutet
Obesity
Exercise Training in Obesity-prone Black and White Women
Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training.
- Trial name
- NCT00067873
- Testing
- Diet, Aerobic exercise, Resistance exercise
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetes Mellitus, Diabetes Mellitus, Type 2
Determinants of Bone and Muscle Quality and Strength in Obesity With and Without Diabetes
Background: Osteoporotic fractures are a major public health issue. They cause substantial disability, loss of autonomy, morbidity and excess mortality.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Obesity, Body Weight
- Trial name
- BODI2 (NCT04093856)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Suzanne Morin
Obesity
Effects of Alcohol After Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: gastric bypass, sleeve gastrectomy, and lap banding. The surgery is not part of the clinical trial.
- Trial name
- RBA (NCT01843257)
- Testing
- Alcohol challenge test Alcohol visit first
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Hypothalamic Obesity
A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients
The extension protocol is designed to allow those patients randomized to placebo in the core portion of the protocol to receive a 6 month treatment of open label octreotide and allow those patients randomized to octreotide who…
- Trial name
- NCT00171613
- Testing
- Octreotide
- Volunteers
- 32 people
- Sponsor
- Novartis
Infant,Premature, Body Weight
Serial Assessment of Body Fat Accrual in Very Preterm Infants
Despite evidence that both rapid weight gain and excessive body fat accrual are associated with overweight and obesity, usual neonatal care of preterm infants does not include assessment of body fat accrual.
- Conditions
- Infant,Premature, Body Weight, Adiposity
- Trial name
- NCT03575897
- Testing
- Assessment of infant body composition
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA
The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS) to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged bout of endurance running and, 2) determine…
- Trial name
- NCT00000110
- Testing
- magnetic resonance spectroscopy, dietary fat
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Obesity, Cardiovascular Disease
Primary Prevention Study: Study on Obesity, Cardiovascular and Psycho-Social Characteristics in the City of Merzig
Cardiovascular risk factors and psycho-social characteristics will be determined in obese and non-obese patients in the setting of primary medical care.
- Conditions
- Obesity, Cardiovascular Disease, Depression, Stress
- Trial name
- NCT00111059
- Where
- 2 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University Hospital, Saarland