Clinical trials: Overweight (BMI > 30)
Obesity, Healthy
Effect of Bile Acids on Satiety, Cell Function and Body Weight in Patients With Obesity and Abnormal Satiety Phenotype
The purpose of this research is to study the effect of the study drug (a conjugated bile acid dietary supplement) or placebo on cell function, hormones and body weight.
- Trial name
- NCT05314374
- Testing
- Ileocolonic-release conjugated bile acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2, Insulin Resistance
New Frontiers on Bariatric Surgical Procedures: Classical Bypass for Type-2 Diabetic Patients With Obesity Grade I
Bariatric surgery leads to remission of type 2 diabetes in morbid obese patients in 80% (Roux-en-Y gastric bypass)to 90% (biliopancreatic diversion and duodenal switch) of cases.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566189
- Testing
- Roux-en-Y Bypass Gastroplasty
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Mask Ventilation, Obese Patients (BMI ≥ 30 kg/m²)
Comparison of Mask Ventilation in Obese Patients by Differents One Hand Techniques
The goal of this controled clinical trial study to know if hook tecnique method is better than other traditional one hand ventilation methods in acheiving effective ventilation in obese patients .
- Conditions
- Mask Ventilation, Obese Patients (BMI ≥ 30 kg/m²), Obesity & Overweight, Bag-mask Ventilation
- Trial name
- E&c / T&E (NCT06817083)
- Testing
- E-C Clamp Technique, T-E Technique, The Hook Technique
- Where
- Egypt
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Aswan University
Obese
Addressing Place and People Micro Environments in Weight Loss Disparities
The purpose of this study is to A) capture obesogenic cues that occur in daily life, and B) to deliver cue alerts. Investigators hypothesized that A) black women experience more cues, B) racial disparities in obesity are reduced…
- Trial name
- APP-ME (NCT03083964)
- Testing
- Usual Care, Priming
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity
Safety and Efficacy of Adjustable Gastric Band Operations for Patients With Body Mass Index (BMI) Between 30-40 kg/m2
This study is to evaluate the safety and efficacy of Gastric Banding for patients with body mass index (BMI) between 30-40 kg/m2 with medical conditions related to obesity.
- Trial name
- LBMI (NCT00580502)
- Testing
- LAP-BAND® Adjustable Gastric Band (LAGB®)
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Bipolar Disorder (BD), Bipolar Disorder Depression
Time Restricted Eating (TRE) in Bipolar Disorder
This is a randomized controlled trial investigating the effects of an 8-TRE intervention compared to a wait list (control) on metabolic health and body composition in people diagnosed with BD and who are currently obese and at…
- Conditions
- Bipolar Disorder (BD), Bipolar Disorder Depression, Overweight (BMI > 30)
- Trial name
- TREBD (NCT07211217)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm
Negative Pressure Wound Therapy in Healing Abdominal Incision in Obese Patients Undergoing Breast Reconstruction Surgery
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery.
- Conditions
- Body Mass Index Greater Than or Equal to 30, Malignant Breast Neoplasm, Mammoplasty Patient, Obesity
- Trial name
- NCT04003038
- Testing
- Negative Pressure Wound Therapy, Wound Care Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30)
Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D)
The goal of this clinical trial is to determine whether Endoscopic Sleeve Gastroplasty (ESG)-induced weight loss can improve glycemic outcomes and alter the trajectory toward insulin dependence in adults with obesity and…
- Trial name
- MEASURE (NCT07639684)
- Testing
- ESG with OverStitch
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Obesity, Pregnancy
Sleep Apnea, Obesity and Pregnancy
Main objective: Determine the prevalence of obstructive sleep apnea syndrome (OSA) in late pregnancy in a population of obese patients .
- Trial name
- GOS (NCT02029859)
- Testing
- Polygraphic examination
- Where
- 4 sites in France
- Volunteers
- 205 people
- Sponsor
- University Hospital, Rouen
Obesity and Cardiovascular Risk, Insulin Resistance
Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)
Obesity is a chronic disease of global public health concern, contributing to cardiovascular disease, type 2 diabetes and certain cancers.
- Conditions
- Obesity and Cardiovascular Risk, Insulin Resistance, Obesity (Body Mass Index >30 kg/m2)
- Trial name
- MOWRI (NCT07297290)
- Testing
- Metformin
- Where
- 2 sites in Nigeria
- Volunteers
- 220 people
- Sponsor
- University Of Nigeria Teaching Hospital
Obesity, Pregnancy
Randomized Controlled Trial: Induction of Labour of Obese Women With Dinoprostone or Single Balloon Catheter
The purpose of this study is to compare the efficacy of single balloon foley catheters to dinoprostone for the induction of labour of obese women.
- Conditions
- Obesity, Pregnancy, Labor, Induced
- Trial name
- NCT01962831
- Testing
- Dinoprostone, Single balloon foley catheter
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Obesity, Overweight, or Chronic Weight Management
Aleniglipron Phase 2 Body Composition Study
This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity.
- Trial name
- NCT07169942
- Where
- 11 sites in United States
- Volunteers
- 71 people
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Obesity (BMI>30), General Anesthesia
Frontal EEG Dynamics During Anesthesia in Patients With Obesity and Normal Weight
This prospective observational study aims to compare frontal electroencephalographic (EEG) spectral dynamics between patients with obesity and normal weight undergoing general anesthesia.
- Trial name
- NCT07877090
- Testing
- Frontal Electroencephalography Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Duzce University
Fasting, Obesity (BMI>30)
The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix
The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI >30).
- Conditions
- Fasting, Obesity (BMI>30), Sex Difference
- Trial name
- GlycoFast84 (NCT07692646)
- Testing
- Diet
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Endoscopic Gastric Reduction for Weight Management
The proposed study is a prospective, pilot study to assess the feasibility of a novel endoscopic suturing system to reduce gastric volume by changing the shape of the stomach for the primary treatment of obesity.
- Trial name
- NCT01682733
- Testing
- Botulinum toxin, Overstitch Endoscopic Suturing System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Obesity (BMI>30)
Workplace Intervention Including Exercise and Nutrition in Obese Office Workers
The main objective of this study is to investigate the efficacy of a 6-month workplace combined (exercise and nutrition) intervention in obese office workers, using a randomized controlled study.
- Trial name
- NCT07603141
- Testing
- Workplace combined (exercise and nutrition) intervention
- Where
- Greece
- Volunteers
- 36 people
- Sponsor
- University of Thessaly
Obesity & Overweight
Influence of the Urolithin A on the Population With BMI Higher Than 30 During Restricted Eating.
Purpose. This study will test whether daily Urolithin A (500 mg) for 6 months helps adults with obesity lose weight while preserving functional muscle mass and improving markers of mitochondrial health, inflammation, and…
- Trial name
- Obesity UroA (NCT07377136)
- Testing
- Urolithin A 500mg
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- Charles University, Czech Republic
Asthma, Allergic, Asthma
IL13 Signaling in Allergic Asthma
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic…
- Conditions
- Asthma, Allergic, Asthma, Obesity
- Trial name
- NCT05478824
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Obesity
Colonoscopy in the Prone Position for Patients With BMI Greater Than 30
In the United States, colonoscopy has become the most commonly used screening test for colorectal cancer. Colonoscopy is typically performed with the patient starting in the left lateral decubitus position, however there is…
- Trial name
- NCT03337217
- Testing
- Position during colonoscopy
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2)
PHArmaCokinetics of methYLphenidate in Adult Patients With Attention-Deficit /Hyperactivity Disorder
PHACYLOB PHArmaCokinetics of methYLphenidate in adult patients with Attention-Deficit Hyperactivity Disorder (ADHD) : comparison between patients with and without OBesity.
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Obesity (Body Mass Index &Amp;Amp;gt;30 kg/m2), Methylphenidate, Obesity &Amp; Overweight
- Trial name
- PHACYLOB (NCT07121621)
- Testing
- PHArmacoKinetics of methYLphenidate in adult patients with ADHD: comparison between patients with and without OBesity.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours