Clinical trials: Overweight/Obesity, active
PreDiabetes, Diabetes Mellitus, Type 2
Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources
The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or…
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Overweight and Obesity
- Trial name
- KETO-IM (NCT05681468)
- Testing
- Keto-SAT, Keto-CAN, LFD
- Where
- Canada
- Volunteers
- 164 people
- Sponsor
- University of Alberta
High Blood Sugar, High Blood Pressure
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides.
- Conditions
- High Blood Sugar, High Blood Pressure, Overweight and Obesity
- Trial name
- NCT06555393
- Testing
- Egg White Powder
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Overweight and Obesity
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending doses of WVE-007 when administered subcutaneously (SC) .
- Trial name
- INLIGHT (NCT06842186)
- Testing
- WVE-007
- Where
- 7 sites in United States, Moldova and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wave Life Sciences USA, Inc.
Overweight and/or Obesity, Metabolic Syndrome
iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) +Optimized Lifestyle Intervention (OLI) vs Sham + OLI for Weight Loss
This randomized, sham-controlled trial evaluates the efficacy and safety of ERCG plus optimized lifestyle intervention compared with sham procedure plus optimized lifestyle intervention in Chinese adults with overweight…
- Conditions
- Overweight and/or Obesity, Metabolic Syndrome, Nonalcoholic Fatty Liver Disease
- Trial name
- iWAIST-RCT (NCT07237750)
- Testing
- Endoscopic Radial Compression Gastroplasty, Optimized Lifestyle Intervention (OLI)
- Where
- 2 sites in China
- Volunteers
- 216 people
- Sponsor
- Liu Yan
Obesity & Overweight
Influence of the Urolithin A on the Population With BMI Higher Than 30 During Restricted Eating.
Purpose. This study will test whether daily Urolithin A (500 mg) for 6 months helps adults with obesity lose weight while preserving functional muscle mass and improving markers of mitochondrial health, inflammation, and…
- Trial name
- Obesity UroA (NCT07377136)
- Testing
- Urolithin A 500mg
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- Charles University, Czech Republic
Class I/II Obesity
Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss
The goal of this clinical trial is to learn about the nature of brain abnormalities associated with excess body fat in healthy adults aged 35-55.
- Trial name
- THRIVE (NCT07592546)
- Testing
- semaglutide
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Alain Dagher
Overweight or Obesity
Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing…
- Trial name
- NCT07685808
- Testing
- Olatorepatide
- Where
- 21 sites in United States
- Volunteers
- 360 people
- Sponsor
- Regeneron Pharmaceuticals
Obesity & Overweight
Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity
The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devices, including: bioelectrical impedance analysis (BIA) devices, 3-dimensional optical imaging (3DO), manual…
- Trial name
- REAL-BODY (NCT07776678)
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Foundation for the National Institutes of Health
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
Obesity & Overweight
Motivational Interviewing Intervention for Families With Overweight and Obesity
The COVID-19 lockdown fostered unhealthy eating habits and reduced physical activity levels, leading to weight gain, sedentary behavior, and increased anxiety and sleep disorders.
- Trial name
- FAMVIVSAL (NCT07893717)
- Testing
- Motivational interviewing to reduce obesity, Traditional nutritional counseling
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Universidad Autonoma de Baja California
Obesity & Overweight
Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.
The purpose of this study is to investigate whether lifestyle factors can alter gut barrier integrity and whether disruptions of the gut barrier can trigger systemic and tissue-specific inflammation.
- Trial name
- ChIPS (NCT07893743)
- Testing
- Fast-food overfeeding
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Overweight, Obesity
A Study to Evaluate the Effects of a Dietary Supplement on Weight Management and Appetite Control
This is a randomized, double-blind, placebo-controlled, decentralized clinical trial evaluating the effects of MN Nutra GeLiPthin-1™, a multi-ingredient dietary supplement, on body weight, BMI, waist circumference, appetite…
- Conditions
- Overweight, Obesity, Weight Management, Appetite Control
- Trial name
- NCT07895563
- Testing
- MN Nutra GeLiPthin-1™ Dietary Supplement
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- MNnutra
Overweight or Obesity Without Diabetes
Efficacy And Safety of Olatorepatide in Adults With Overweight or Obesity Without Diabetes
This study will test olatorepatide (study drug) to determine whether it can help treat overweight or obesity. In this study we will test how safe and how well olatorepatide works compared to placebo in people who are overweight…
- Trial name
- RISE-1 (NCT07896265)
- Testing
- Olatorepatide
- Volunteers
- 3,000 people
- Sponsor
- Regeneron Pharmaceuticals
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Obesity, Obesity & Overweight
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
This is a real-world study. The purpose of this research is to explore whether a new National Institute for Health and Care Excellence (NICE)-approved digital weight-management model of care can improve health service delivery…
- Trial name
- RENEW (NCT07283978)
- Testing
- Digital Weight Management Programme
- Where
- United Kingdom
- Volunteers
- 580 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obese, Overweight
A Study of SA030 Injection in Overweight or Obese Participants
This study is the first time SA030 is being given to people. The goal is to understand how safe it is, how well it is tolerated, and how the body processes and responds to a single dose of SA030 in individuals who are overweight…
- Trial name
- NCT07479862
- Testing
- SA030 Injection
- Where
- 2 sites in Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Suzhou Siran Biotechnology Co.,Ltd.
Overweight or Obesity
A Single Ascending Dose and Multiple Ascending Doses Study of SYH2082 Injection in Healthy Participants
To evaluate the safety and tolerability of single dose and multiple doses of SYH2082 Injection in healthy participants.
- Trial name
- NCT07532655
- Testing
- SYH2082 Injection
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Obesity or Overweight
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.
- Trial name
- NCT07575399
- Testing
- Maridebart Cafraglutide
- Where
- 54 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Amgen
Type 1 Diabetes, Overweight , Obesity
Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity.
The goal of this 24 week double-blinded, randomized, parallel controlled clinical trial is to learn how semaglutide affects body composition in adults with type 1 diabetes and overweight/obesity.
- Trial name
- SEMA-T1D-BODY (NCT07891156)
- Testing
- Semaglutide
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Physical Inactivity, Overweight
Individual Variability in Energy Compensation After a 12-Week Supervised Exercise Intervention
This prospective, single-arm interventional study will investigate why adults receiving the same prescribed dose and relative intensity of exercise show divergent changes in energy balance, body weight, and body composition.
- Conditions
- Physical Inactivity, Overweight, Obesity
- Trial name
- NCT07893249
- Testing
- Supervised Aerobic Exercise Programme
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences