Clinical trials: Ovarian Insufficiency
Premature Ovarian Insufficiency
Finerenone for Premature Ovarian Insufficiency (POI)
This study is testing whether finerenone, a medicine currently used to protect the kidneys and heart, can help women with premature ovarian insufficiency (POI) grow ovarian follicles and produce eggs that can be collected for in…
- Trial name
- NCT07815509
- Testing
- Finerenone
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Ovarian Failure
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Ovarian Failure
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Ovarian Failure
- Trial name
- NCT05158933
- Testing
- AlloRx
- Where
- Antigua and Barbuda
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Breast Cancer, Osteoporosis
Zoledronate, Calcium, and Vitamin D in Preventing Bone Loss in Women Receiving Adjuvant Chemotherapy for Breast Cancer
RATIONALE: Zoledronate plus calcium and vitamin D may prevent bone loss in patients receiving adjuvant chemotherapy for breast cancer. It is not yet known which regimen is more effective in preventing bone loss.
- Trial name
- NCT00022087
- Testing
- calcium salts, cholecalciferol, zoledronic acid
- Where
- 107 sites in United States
- Volunteers
- 439 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Primary Ovarian Insufficiency
Ovarian Laparoscopic In Vivo Activation of Ovary for Premature Ovarian Insufficiency
The OLIVA device will enable to perform shallow slashes on the ovarian cortex in patients undergoing oophorectomy. Prior to the resection of the ovary from the pedicle we will perform 5 parallel slashes 3 cm long.
- Trial name
- OLIVA (NCT03034616)
- Testing
- OLIVA device
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Amenorrhea, Premature Ovarian Failure
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
Primary Objectives: To determine the effectiveness of the 3-month depot leuprolide in inducing and maintaining secondary amenorrhea in patients undergo hematopoietic stem cell transplantation.
- Conditions
- Amenorrhea, Premature Ovarian Failure, Ovarian Function Insufficiency
- Trial name
- NCT00429494
- Testing
- Leuprolide Acetate, Questionnaire, Hematopoietic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Function Insufficiency, Fertility Issues
Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells
To study the influence of different daily rec-FSH dosages (150 IU versus 300 IU), performed in the same patient in consecutive cycles, on the relation between FSH- and LH-receptors of the granulosa cells of the growing follicle.
- Conditions
- Ovarian Function Insufficiency, Fertility Issues, Infertility,Female, Infertility
- Trial name
- NCT05330130
- Testing
- Follitropin beta injection 150 IU, Follitropin beta injection 300 IU
- Where
- United Arab Emirates
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
AMH, Diet Habit
Effect of Antimullerian Hormone Levels on the Inflammatory Index, Phytochemical Index and NRF Nutrient Density
The aim of the study was to calculate the dietary inflammatory index, dietary phytochemical index and NRF nutrient density of the dietary pattern routinely consumed by women and to assess whether there is a difference between…
- Conditions
- AMH, Diet Habit, Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- AMH (NCT06426771)
- Testing
- Dietary Inflammatory Index, hormone profile
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Dysfunction; Endocrine, Effects of Chemotherapy
Blood Spot Self-administered Test and Assay
The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.
- Conditions
- Dysfunction; Endocrine, Effects of Chemotherapy, Premature Ovarian Failure
- Trial name
- NCT03840824
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Activation of Primordial Follicles
Ovarian Needle Puncture for Follicle Activation in IVF Patients With Diminished Ovarian Reserve
Premature ovarian insufficiency (POI), is cessation of ovarian function characterized by hypergonadotropic amenorrhea and hypoestrogenic syndrome before 40 years of age.
- Trial name
- NCT04608695
- Testing
- Ovarian puncture
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Premature Ovarian Failure (POF)
Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure
This study aims to recover ovarian function in POF/POI patients. With this pueprose we designed a study protocol including two arms: ASCOT arm, were patients receive the stem cell mobilization treatment with Granulocyte colony…
- Trial name
- ASCOT-2 (NCT03535480)
- Testing
- G-CSF, ASCOT
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Infertility, Polycystic Ovary Syndrome
A New Algorithm to Predict Ovarian Age
To collect data of clinical, biochemical and 3D-ultrasonographic parameters of a population of fertile women aged 18-55 in order to design a new algorithm able to predict ovarian age and to evaluate the reliability of a…
- Conditions
- Infertility, Polycystic Ovary Syndrome, Premature Ovarian Failure (POF), Ovarian Cysts
- Trial name
- OvAge (NCT02086318)
- Testing
- OvAge assessment
- Where
- Italy
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Primary Ovarian Insufficiency
Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women
The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.
- Trial name
- NCT03518918
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Infertility, Female, Ovarian Insufficiency
Benefit of Follicular Flushing During Oocyte Retrieval for Poor Responder Patient in an Assisted Reproductive Technology Program
The object of this study is to determine the benefit of follicular flushing with a double channel needle in a poor responder population for a maximum number of oocytes to be retrieved.
- Trial name
- NCT01329302
- Testing
- Direct aspiration needle Echo tip® Cook® single Lumen and Follicular flushing with double lumen needle Echo tip® Cook® Double Lumen Aspiration
- Where
- France
- Volunteers
- 257 people
- Sponsor
- University Hospital, Strasbourg, France
Premature Ovarian Insufficiency
Phase Ⅰ/Ⅱa Trial Evaluating Intravenous hUC-MSCs Injection for Safety, Tolerability and Efficacy in Patients With POI
A Phase I/IIa clinical study evaluating the safety, tolerability and efficacy of intravenously administered human umbilical cord mesenchymal stem cell (hUC-MSCs) injection in patients with premature ovarian insufficiency (POI).
- Trial name
- NCT07775391
- Testing
- hUC-MSCs Injection (Phase I), hUC-MSCs Injection (Phase IIa)
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shenzhen Wingor Biotechnology Co., Ltd.
Cardiovascular Diseases
Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile
The polycystic ovary syndrome (PCOS) is the most common endocrinopathy amongst women of reproductive age. PCOS is associated with various cardiovascular risk factors such as obesity, glucose intolerance, dyslipidemia hypertension…
- Trial name
- POPCORn (NCT02616510)
- Testing
- cardiovascular screening
- Where
- Netherlands
- Volunteers
- 125 people
- Sponsor
- UMC Utrecht
Premature Ovarian Failure (POF), Incipient Ovarian Failure
Pheno- & Genotyping POF (WHO III)
This study focuses on the phenotyping and genotyping of women with hypergonadotropic ovarian dysfunction (WHO III status).
- Conditions
- Premature Ovarian Failure (POF), Incipient Ovarian Failure, Poor Response After Ovarian Hyperstimulation, Early Menopause
- Trial name
- NCT01411644
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- UMC Utrecht
Premature Ovarian Insufficiency, Reproductive Health
Microbiome and Premature Ovarian Insufficiency
This study investigates the differences in gut and vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy volunteers.
- Trial name
- NCT07275671
- Where
- 2 sites in China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Westlake University
Premature Ovarian Failure
Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patients
To Prevent Chemotherapy Induced Ovarian Failure with the gonadotropin-releasing hormone Agonist Goserelin in Young female Lymphoma Cancer patients Receiving Chemotherapy
- Trial name
- NCT04536467
- Testing
- Goserelin, Chemotherapy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University
Breast Cancer, Hot Flashes
S9626: Megestrol in Treating Hot Flashes Following Treatment for Breast Cancer
RATIONALE: Megestrol may be effective in treating hot flashes following treatment for breast cancer. It is not yet known which regimen of megestrol is most effective for hot flashes.
- Trial name
- NCT00005975
- Testing
- Megestrol Acetate 20mg/day, Megestrol Acetate 40 mg/day
- Volunteers
- 288 people
- Sponsor
- SWOG Cancer Research Network