Clinical trials: Ovarian Failure
Primary Ovarian Insufficiency
Ovarian Laparoscopic In Vivo Activation of Ovary for Premature Ovarian Insufficiency
The OLIVA device will enable to perform shallow slashes on the ovarian cortex in patients undergoing oophorectomy. Prior to the resection of the ovary from the pedicle we will perform 5 parallel slashes 3 cm long.
- Trial name
- OLIVA (NCT03034616)
- Testing
- OLIVA device
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Galactosemia, Premature Ovarian Failure
Inactive FSH in Galactosemia
The aim of the study is to investigate whether inactive FSH plays a role in the development of Premature Ovarian Failure in women with Classic Galactosemia
- Trial name
- NCT00619333
- Testing
- follitropin and lutropin
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Infertile Females or Females With Ovarian Insufficiency
Ovarian Tissue Transplantation
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol…
- Trial name
- NCT01870752
- Testing
- Transplantation of previously cryopreserved ovarian tissu
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Fertilization Failure
Calcium Ionophore Solution Can Increase Fertilization Rate in Patients During Intracytoplasmic Sperm Injection(ICSI) Who Have Poor Ovarian Reserve?
The aim of this study is to evaluate calcium ionophore solution on fertilization rate of patients during intracytoplasmic sperm injection who have poor ovarian reserve
- Trial name
- NCT02045914
- Testing
- calcium ionophore solution
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Baskent University
Clomiphene Citrate, Resistant Ovary Syndrome
Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate
This study evaluate the addition of PTX and ALA to clomiphene citrate in the treatment of polycystic ovary.
- Conditions
- Clomiphene Citrate, Resistant Ovary Syndrome, Polycystic Ovary Syndrome
- Trial name
- NCT05231980
- Testing
- Alpha lipoic acid (ALA), Pentoxifylline (PTX), Clomiphene Citrate
- Where
- 3 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Premature Ovarian Failure
Autologous Bone Marrow Transplantation for Premature Ovarian Insufficiency
Currently, There is no treatment for Premature ovarian insufficiency (POI). Very small embryonic-like stem cells (VSELs) are found in the ovary. VSELs are able to regenerate the affected ovary.
- Trial name
- BMT-POI (NCT02779374)
- Testing
- Autologous bone marrow transplantation
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- South Valley University
Autoimmune Disease, Infertility
Steroid Therapy in Autoimmune Premature Ovarian Failure
No therapy for infertile patients with premature ovarian failure has been proven effective. Some anecdotal reports have suggested that high dose, long term prednisone (steroid) therapy may be useful in treating autoimmune ovarian…
- Conditions
- Autoimmune Disease, Infertility, Premature Ovarian Failure
- Trial name
- NCT00001306
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Polycystic Ovary Syndrome
A New Algorithm to Predict Ovarian Age
To collect data of clinical, biochemical and 3D-ultrasonographic parameters of a population of fertile women aged 18-55 in order to design a new algorithm able to predict ovarian age and to evaluate the reliability of a…
- Conditions
- Infertility, Polycystic Ovary Syndrome, Premature Ovarian Failure (POF), Ovarian Cysts
- Trial name
- OvAge (NCT02086318)
- Testing
- OvAge assessment
- Where
- Italy
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Polycystic Ovary Syndrome
Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)
PolysCsytic Ovaries Syndrome (PCOS) is the most frequent endocrinopathy. The first stage of infertility treatment is Clomiphene Citrate which leads to 50 % pregnancies.
- Trial name
- PERCING (NCT00378729)
- Testing
- Metformin and FSHr, Ovarian drilling by FERTILOSCOPY
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Reserve, Acupuncture Therapy
Clinical Efficacy of Acupuncture on the Liver Meridian in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in impaired ovarian function and decreased fertility.
- Conditions
- Ovarian Reserve, Acupuncture Therapy, Meridian
- Trial name
- GJZLLCCBGNXJ (NCT05743218)
- Testing
- electropuncture
- Where
- China
- Volunteers
- 198 people
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Premature Ovarian Insufficiency
Exploratory Clinical Study on the Efficacy and Safety of Lactobacillus Johnsonii in the Treatment of Patients with Premature Ovarian Insufficiency
The goal of this clinical trial is to explore the effectiveness and safety of Lactobacillus johnsonii in improving ovarian function and perimenopausal symptoms in patients with premature ovarian insufficiency (POI).
- Trial name
- NCT06866990
- Testing
- Lactobacillus johnsonii
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Ovarian Insufficiency
Clinical Observation on Kuntai Capsule in Treating Early-onset Ovarian Hypofunction
To evaluate the efficacy and safety of Kuntai capsule alone or combined with hormone therapy in improving ovarian function in POI patients (including subclinical stage).
- Trial name
- NCT05021094
- Testing
- Kuntai Capsule, Femoston
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Nantong University
Menopause, Primary Ovarian Insufficiency (Poi)
Menopause Age and Anxiety-Depression
Menopause is defined as the permanent cessation of menstrual cycles due to ovarian follicle depletion, typically occurring after age 50, and is associated with decreased estrogen levels.
- Conditions
- Menopause, Primary Ovarian Insufficiency (Poi), Anxiety, Depression
- Trial name
- NCT07295093
- Testing
- Beck Anxıety Inventory (BAI), State-Trait Anxiety Scale (STAI) 1-2
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Ovarian Insufficiency, Radiation Exposure
Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer
Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy if indicated.
- Trial name
- NCT04396158
- Testing
- radioactive iodine
- Volunteers
- 38 people
- Sponsor
- Assiut University
Ovarian Failure, Premature
Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian Failure
To directly compare the safety (by laboratory evaluation) and efficacy (feminization and growth) of three commonly used estrogen preparations in adolescent patients with ovarian failure, either due to congenital causes (Turner…
- Trial name
- NCT01023178
- Testing
- 17beta Estradiol, Conjugated estrogens, 17Beta Estradiol - transdermal
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Sex Behavior, Ovarian Failure
Effects of Ovarian Reserve on Sexual Satisfaction
This is a survey study. The primary aim of the study is to investigate the relationship between the ovarian reserve and sexual satisfaction.
- Trial name
- EROSS (NCT04776902)
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Uludag University
Poor Ovarian Response, Ovarian Reactivation
Proteomic and Biological Characterisation of Plasma for the Study of Changes Following Ovarian Reactivation Treatment
The samples used in PRGF treatments owe their effectiveness to the handling, concentration, and preservation of their components, which explains why samples obtained with different platelet-rich plasma preparation systems may…
- Trial name
- NCT07376460
- Testing
- Platelet Rich Plasma + BMDSCs mobilization
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Autoimmune Diseases, Premature Ovarian Insufficiency
Immunomodulatory Therapy in Women With Autoimmune Premature Ovarian Insufficiency
Title: Effects of immunomodulatory therapy on gonadal function in women with autoimmune premature ovarian insufficiency (POI) Trial objectives and purpose: To study if rituximab therapy can improve ovarian response to…
- Trial name
- NCT05586737
- Testing
- Rituximab
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Angelica Lindén Hirschberg