Clinical trials: Ovarian Aging
Breast Cancer, Fertility
Investigating the Impact of Tamoxifen Therapy on Ovarian Aging
Ovarian toxicity is a well-described side effect of traditional chemotherapy in premenopausal women receiving treatment for early stage breast cancer.
- Trial name
- NCT01384526
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- University of California, San Francisco
Infertility, Female, Infertility Unexplained
Effects of Age and Infertility on Ovarian Granulosa Cell Function
Infertility is a life changing disorder, affecting 1 in 7 couples within the UK. Treatment options pose a significant cost burden to both the NHS and patient when NHS-funded treatment options are exhausted.
- Conditions
- Infertility, Female, Infertility Unexplained, Infertility of Tubal Origin, Infertility
- Trial name
- NCT04945265
- Volunteers
- 500 people
- Sponsor
- King's College London
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Unrecognized Condition
Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders
The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.
- Trial name
- NCT05873075
- Testing
- Intravascular laser irradiation of blood
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Aging
Age-related Changes in Ovarian Follicular Wave Dynamics
The investigators hypothesize that age-related changes in the number and growth dynamics of ovarian follicles will be associated with changes in hormone levels and corresponding changes in musculoskeletal health.
- Trial name
- NCT01389141
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Perimenopausal
Effect of Rapamycin in Ovarian Aging
The investigators are proposing a prospective, randomized, double-blind, placebo-controlled pilot study assessing the ability of low-dose rapamycin to delay ovarian aging in women.
- Trial name
- Rapamycin (NCT05836025)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Ovarian Aging, In Vitro Fertilisation (IVF) Treatment
Follicular Fluid microRNAs in Ovarian Aging and Reproduction
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes.
- Conditions
- Ovarian Aging, In Vitro Fertilisation (IVF) Treatment, InVitro Fertilization, In Vitro Fertilization Outcome
- Trial name
- NCT07214246
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Central Florida
Menopause, Estrogen Deficiency
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the menopause transition.
- Conditions
- Menopause, Estrogen Deficiency, Women, Aging
- Trial name
- NCT05057546
- Testing
- GnRH antagonist
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Age of the Patients and the Body Mass Index in Both Groups
Differences in Ovarian Aging Between Caucasian and Indian Women
The investigators want to carry out a prospective study of 400 infertile Caucasian and Indian women who will undergo a controlled ovarian stimulation for in vitro fertilization (IVF).
- Trial name
- NCT02210013
- Volunteers
- 400 people
- Sponsor
- IVI Madrid
Infertility
Genetic Epidemiology of Ovarian Aging
The purpose of this study is to identify clinical and genetic markers of ovarian aging. In this process, we will evaluate environmental factors that may affect fertility and the age at which fertility declines, and may influence…
- Trial name
- NCT00501800
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Primary Ovarian Insufficiency, Unexplained Infertility
Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with otherwise unexplained infertility and evidence of premature ovarian aging (POA).
- Trial name
- DHEAFert (NCT00650754)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diminished Ovarian Reserve, Diminished Ovarian Reserve Due to Advanced Maternal Age
Ovarian Function Following Intraovarian Injection of PRP
Consenting women with evidence of poor ovarian reserve will be randomly assigned to treatment with either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP).
- Trial name
- PRP4POA (NCT04278313)
- Testing
- PRP - Platelet Rich Plasma, PPP - Platelet Poor Plasma
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Cardiovascular Risk Factor
The Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
Despite significant improvements in prevention and treatment of cardiovascular disease (CVD), the growing aging population suggests CVD will continue to pose a significant public health burden.
- Trial name
- OVACV (NCT03825120)
- Where
- United States
- Volunteers
- 865 people
- Sponsor
- University of California, San Francisco
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infertility Assisted Reproductive Technology, Ovarian Aging
Epigenetic Clock to Predict Ovarian Aging and Live Birth in ART
Epigenetic clocks based on DNA methylation estimate biological age and are associated with age-related conditions, but they have not been validated for female fertility.
- Trial name
- ARTCLOCK (NCT07875140)
- Testing
- Peripheral blood sampling for epigenetic age estimation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ovarian Aging
A Multicenter Clinical Study of Yijing Keli in the Treatment of Ovarian Aging
Ovarian aging (OA) seriously affects the physical and mental health of women. Nowadays, Chinese herbs have huge appeal and potential in treating OA.
- Trial name
- NCT06271928
- Testing
- Yijing Keli
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
The Correlation Between Ovarian Function and Serum Biomarkers
The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Biomarker, Copper
- Trial name
- NCT06096766
- Testing
- blood test
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Menopause, Obesity, Abdominal
Bioenergetic Effects of Aging and Menopause (BEAM)
The menopause transition is associated with increased risk for weight gain and a shift toward storing fat in the belly region, which may increase risk for cardiovascular disease and diabetes.
- Conditions
- Menopause, Obesity, Abdominal, Aging, Weight Gain
- Trial name
- BEAM (NCT04043520)
- Testing
- GnRH antagonist, Estrogen Product
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver