Clinical trials: Otitis
Acute Otitis Media
Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in Children
This study aims to compare the effectiveness of two treatments for children with acute otitis media (middle ear infection). The two treatments being compared are amoxicillin alone and a combination of amoxicillin plus clavulanic…
- Trial name
- NCT06895135
- Testing
- Amoxicillin, Clavulanic Acid
- Volunteers
- 162 people
- Sponsor
- University of Health Sciences Lahore
Otitis Media With Effusion
Otitis Media With Effusion and Type 2 Inflammation Diseases
Otitis media with effusion (OME) is thought to be associated with comorbidities such as allergic rhinitis, gastroesophageal reflux disease, asthma, and more. Many of these comorbidities can be caused by type 2 inflammation (T2I).
- Trial name
- NCT06403319
- Volunteers
- 100,622 people, healthy volunteers welcome
- Sponsor
- Hearing and Language Healthcare Center, China Medical University Hsinchu Hospital, Taiwan
Acute Otitis Media
Does Tympanometry Predict Antibiotic Usage in Acute Otitis Media?
Due to recent efforts to decrease antibiotic overuse, and reports of high rates of spontaneous resolution for clinically diagnosed Acute Otitis Media(AOM), most physicians now wait 48-72 hours before starting antibiotics for…
- Trial name
- NCT01941381
- Testing
- Tympanometry
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of Alberta
Acute Otitis Media
Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan
The purpose of the study is to identify the bacterial aetiology of Acute Otitis Media episodes in young children aged >= 3 months to < 5 years in Taiwan
- Trial name
- NCT01072227
- Testing
- Sample Collection
- Where
- 2 sites in Taiwan
- Volunteers
- 10 people
- Sponsor
- GlaxoSmithKline
Otitis Media
Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media
The purpose of this study is to demonstrate non-inferiority of levofloxacin compared with amoxicillin/clavulanate on the clinical response at the end of therapy in infants and children who have recurrent and/or persistent acute…
- Trial name
- NCT00051753
- Testing
- levofloxacin; amoxicillin/clavulanate
- Volunteers
- 1,643 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Otitis Media
Taste Changes in Acute Otitis Media
Detection of taste changes in Acute Otitis Media (AOM) patients.
- Trial name
- NCT03315156
- Testing
- Electrogustometery
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Otitis Externa, Swimmer's Ear
Phase 3 Study of OTO-201 in Acute Otitis Externa
This is a prospective, randomized, double-blind, sham-controlled, multicenter, Phase 3 study in which eligible subjects with acute otitis externa (AOE) will be randomized to receive a single administration of either 12 mg OTO-201…
- Trial name
- NCT02801370
- Testing
- 12 mg ciprofloxacin
- Where
- 2 sites in United States, Canada
- Volunteers
- 262 people
- Sponsor
- Otonomy, Inc.
Acute Otitis Media
Acute Otitis Media (AOM) Therapy Trial in Young Children
The purpose of this study is to learn whether or not all children with ear infections (acute otitis media or AOM) should be treated with antibiotics.
- Trial name
- NCT00377260
- Testing
- amoxicillin-clavulanate
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Pittsburgh
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- PneuMum (NCT00714064)
- Testing
- 23vPPV, dTpa (Pneumovax, Boostrix)
- Where
- Australia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Acute Otitis Externa
A Phase III Study of an Otic Formulation in Acute Otitis Externa
The purpose of this study is to determine if an otic formulation is safe and effective for the treatment of acute otitis externa (AOE).
- Trial name
- NCT00750633
- Testing
- Moxidex otic solution, Moxifloxacin otic solution, Dexamethasone phosphate otic solution
- Volunteers
- 990 people
- Sponsor
- Alcon Research
Chronic Otitis Media
Validity of the French Version of the Quality of Life Questionnaire COMQ12-FR
The World Health Organization estimates that chronic otitis media could reach between 65 and 350 million people worldwide and thus be an important cause of medical consultation and prescription drugs.
- Trial name
- COMQ12-FR (NCT04423952)
- Testing
- COMQ-12 questionnaire
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nasopharyngeal Carcinoma
Occurrence of Radiation-induced Otitis Media in Nasopharyngeal Carcinoma Patients After Intensity Modulated Radiotherapy
This is an observational cohort study to investigate the incidence of radiation-induced otitis media, changes in tubal function and hearing in newly diagnosed nasopharyngeal carcinoma patients without metastasis at multiple time…
- Trial name
- NCT06170021
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Sun Yat-sen University
Acute Otitis Media, Pediatric Infectious Disease
RELAX: Reducing Length of Antibiotics for Children With Ear Infections
The overarching goal of this study is to evaluate the effectiveness and implementation outcomes of two low-cost interventions of different intensities to increase prescribing of recommended short antibiotic durations for acute…
- Conditions
- Acute Otitis Media, Pediatric Infectious Disease, Ear Infection
- Trial name
- RELAX (NCT05608993)
- Testing
- High Intensity Intervention, Low Intensity Intervention
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intermountain Health Care, Inc.
Nasopharyngeal Colonization and Acute Otitis Media
Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children.
The purpose of this study is to Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children.
- Trial name
- AOM (NCT02591563)
- Testing
- procedures
- Where
- United States
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Rochester General Hospital
Otitis Media Acute
Otitis Treatment With OtoSight™ - Modification of Antibiotic Treatment Intervention in Children
A pragmatic, mixed-method trial is to show the ability of OtoSight to change management of the pediatric patient presenting with ear pain in a way that improves patient outcomes and reduces costs.
- Trial name
- OTO-MATIC (NCT06285812)
- Testing
- OtoSight Middle Ear Scope
- Where
- 7 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- PhotoniCare, Inc.
Otitis Media, Serous, Negative Middle Ear Pressure
Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays
We hypothesize that intranasal steroid application will have a beneficial therapeutic effect in adults with regard to resolution of serous otitis media and/or negative middle ear pressure, as compared to placebo.
- Conditions
- Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion
- Trial name
- NCT00279916
- Testing
- Triamcinolone acetonide nasal spray
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Mayo Clinic
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Acute Otitis Media, Otitis Media
Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish Children
The goal of this study is to look at the effect of pneumococcal conjugate vaccines (PCV) on physician-diagnosed otitis media (OM) and acute otitis media (AOM) incidence in Swedish children by collecting and analyzing patient…
- Trial name
- NCT02742753
- Testing
- Data collection
- Where
- Sweden
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infections, Streptococcal
Study to Identify and Characterize Bacteria Causing Acute Otitis Media in Young Children in Turkey
The purpose of this study is to identify and characterize the bacteria causing complicated Acute Otitis Media episode in children >= 3 months to < 5 years in Turkey.
- Trial name
- NCT01031329
- Testing
- Tympanocenthesis and urine collection
- Where
- 8 sites in Turkey (Türkiye)
- Sponsor
- GlaxoSmithKline