Clinical trials: Osteoarthritis, Ankle
Ankle Osteoarthritis
Ankle Osteoarthritis
Ankle osteoarthritis is a progressive degenerative joint disease that is characterized by severe pain, loss of autonomy, diminished health-related quality of life, functional disability and diminished physical ability to fulfill…
- Trial name
- AO-IFAB (NCT03157141)
- Testing
- Ankle arthrodesis, Total ankle replacement
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Degenerative Joint Disease of the Ankle
A Pilot Study to Evaluate the Contribution of the Saphenous Nerve in Ankle Pain of Patients With Degenerative Joint Disease of the Ankle
To assess the pain scores before and after saphenous nerve block placement in patients with degenerative joint disease of the ankle
- Trial name
- NCT01716650
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Osteoarthritis of Multiple Joints of Ankle or Foot, Healthy
Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function
Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy…
- Trial name
- OPIOVASC (NCT03781544)
- Testing
- Tramadol, Paracetamol, Diclofenac
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Osteoarthritis of Multiple Joints of Ankle or Foot
Agili-CTM Implant Performance Evaluation in the Treatment of Osteoarthritis of the Great Toe
The purpose of this study is to evaluate the performance of the Agili-CTM implant in the treatment of osteoarthritis of the Great Toe.
- Trial name
- NCT02831244
- Testing
- Agili-CTM
- Where
- 4 sites in Israel, Italy and 2 more
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis
A Study of the Safety and Efficacy of Synvisc in Patients With Symptomatic Ankle Osteoarthritis
This clinical study is to evaluate the safety and efficacy of Synvisc in patients with symptomatic ankle osteoarthritis (OA). Patients will be given Synvisc, with the possible administration of a second injection where…
- Trial name
- NCT00131768
- Testing
- Synvisc (hylan G-F 20)
- Where
- 5 sites in Germany, Italy and 1 more
- Sponsor
- Genzyme, a Sanofi Company
Knee Osteoarthritis
Effect of Core Stability Versus Ankle Foot Strengthening Exercise in the Management of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disease causing pain, stiffness, and reduced quality of life. While treatments often focus on drugs or surgery, noninvasive exercises like core stabilization and ankle/foot…
- Trial name
- NCT06766877
- Testing
- core stability exercise, foot-ankle strengthening exercise
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis
Efficacy of 3 Weekly Injections of Hyaluronate in Patients With Ankle Osteoarthritis
The aim of this study was to investigate the efficacy and safety of three weekly intraarticular injections of Hyaluronate (HA) in patients with unilateral ankle Osteoarthritis (OA).
- Trial name
- NCT00918736
- Testing
- sodium hyaluronate
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Arthritis, Rheumatoid, Post-traumatic Osteoarthritis
UK Infinity, Post-Market Clinical Follow-up Study
Study Title UK Post-Market Clinical Follow-Up Of The INFINITY® Total Ankle System Study Design Prospective, multi-site, multi-year post-market clinical follow-up study Study Group Primary/Unilateral and/or bilateral Total Ankle…
- Conditions
- Arthritis, Rheumatoid, Post-traumatic Osteoarthritis, Degenerative Arthritis
- Trial name
- NCT03063593
- Where
- 12 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis
Prevention of Post-Traumatic Osteoarthritis (OA)
Joint injury and trauma dramatically increase the risk of developing osteoarthritis (OA). The purpose of this study is to determine what factors lead to decreased pain, improved joint function, and repair of the joint surface in…
- Trial name
- NCT00054821
- Testing
- Ankle distraction permitting motion, Ankle distraction without motion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ned Amendola
Arthrosis, Arthritis
The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery
The study investigates the effect of a ultrasound-guided subsartorial saphenous block on postoperative pain following major ankle and hind foot surgery.
- Trial name
- NCT02697955
- Testing
- Bupivacaine-epinephrine
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Osteoarthritis, Osteoarthritis, Knee
Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
The primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
- Trial name
- NCT03711773
- Testing
- Group Physical Therapy Classes
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Missouri-Columbia
Ankle Osteoarthritis, Knee Osteoarthritis
Gait Asymmetry Assessed Using Portable Gait Analysis System
To date, detailed analysis of movement patterns in orthopaedic conditions are mainly performed in research projects. Because these tests are time consuming, they are not feasible in clinical routine or in standard examinations.
- Conditions
- Ankle Osteoarthritis, Knee Osteoarthritis, Hip Osteoarthritis, Lumbar Spine Stenosis
- Trial name
- Asymmetry (NCT02489188)
- Testing
- arthroplasty, manual therapy, lumbar spinal stenosis decompression
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ankle Sprains
Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation
The purpose of this project is to compare a novel sensorimotor ankle rehabilitation training (SMART) protocol for Lateral ankle sprains (LASs) against a standard of care (SOC) protocol to determine if it is more successful at…
- Trial name
- NCT03663361
- Testing
- SMART Intervention, Standard of Care Intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Phillip Gribble
Ankle Osteoarthritis
Injections of SVF in Ankle Osteoarthritis
The aim of this pilot study is to analyze the effect of SVF injection produced by adipose tissue processing, in terms of clinical improvement, in patients with moderate to severe (stage 1-3) ankle osteoarthritis.
- Trial name
- NCT04998162
- Testing
- SVF injection
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Ankle Osteoarthritis
A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA
Platelet-rich plasma (PRP) has been reported to be an effective treatment for knee osteoarthritis (OA). The application in ankle OA has rarely been investigated.
- Trial name
- NCT04022928
- Testing
- PRP
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis
Treatment Outcomes for Ankle Arthritis
The purpose of this study is to determine any functional outcome differences in patients who have undergone surgical treatment for ankle osteoarthritis using surveys, step counts, and laboratory gait analysis.
- Trial name
- NCT00391365
- Testing
- Gait analysis
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- VA Office of Research and Development
Ankle Osteoarthritis, Flat Foot or Pes Planus
Orthotic Dose Response Study
This study will investigate the effect of foot orthoses on two common conditions (ankle osteoarthritis and symptomatic adult onset flat feet) by using a custom biplane X-ray system the group has developed to very accurately and…
- Trial name
- ODRS (NCT02629731)
- Testing
- custom orthoses with varying degrees of hindfoot posting
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ankle Osteoarthritis
Lateral Approach Versus Anterior Approach in Total Ankle Replacement
A minimum of 50 patients with ankle end-stage arthritis will be randomized in two parallel groups for surgery. One group will receive a total ankle replacement through an anterior approach and the other group a total ankle…
- Trial name
- NCT05562154
- Testing
- Total Ankle Replacement
- Where
- United States
- Sponsor
- John Femino
Ankle Osteoarthritis
Comparison of Customized and Standard Total Ankle Prostheses
The objective of this study is to compare primary total ankle replacement (TAR) performed with a customized procedure (prostheses customized for each patient based on his or her ankle morphology reconstructed from tomographic…
- Trial name
- NCT06193057
- Testing
- Total ankle arthroplasty
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis
Arthroscopic Ankle Arthrodesis: Measuring Post-operative Pain to Assess the Potential for Outpatient Surgery.
Post-operative pain will be measured using a pain diary for one week post-surgery. The purpose is to test the assumption that the arthroscopic technique leads to less post-operative pain and results in shorter hospital stays when…
- Trial name
- NCT01370252
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Hammond, Allan, M.D.