Clinical trials: Osteo Arthritis Knee, active
Osteo Arthritis of the Knee
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question[s] it aims to answer are: Measure the change in average daily knee pain intensity scores from baseline to the end of…
- Trial name
- NCT07819461
- Testing
- Sodium hyaluronate solution - 3.36%, Sterile buffered solution
- Volunteers
- 704 people
- Sponsor
- IBSA Institut Biochimique SA
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Osteo Arthritis Knee, Arthritis Knee
Total Versus Robotic Assisted Unicompartmental Knee Replacement
The purpose of this research is to compare the functional outcomes of patients with end stage medial compartment OA of the knee undergoing a conventional mTKA to those undergoing rUKA and to assess the associated cost economics…
- Conditions
- Osteo Arthritis Knee, Arthritis Knee, Arthropathy of Knee
- Trial name
- TRAKER (NCT05290818)
- Testing
- MAKO™ Partial Knee Arthroplasty, Triathlon (Stryker) Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 159 people
- Sponsor
- NHS Lothian
Osteo Arthritis of the Knee
Comparison of Distal IPACK and Popliteal Plexus Block Combined With Femoral Triangle Block After Total Knee Arthroplasty
This study aims to investigate the effect of femoral triangle block combined with popliteal plexus block and distal IPACK block on postoperative pain after total knee arthroplasty (TKA)
- Trial name
- NCT07130552
- Testing
- femoral triangle block and popliteal plexus block, Femoral triangle block and distal iPACK
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Karaman Training and Research Hospital
Osteo Arthritis of the Knee, Pain
The PERK Study: Predicting and Evaluating Response to Knee RFA Using fNIRS
The goal of this clinical trial is to understand whether changes in brain activity, measured using functional near-infrared spectroscopy (fNIRS), are related to how well patients with knee osteoarthritis respond to genicular…
- Trial name
- PERK (NCT07835269)
- Testing
- Radiofrequency ablation alone, Genicular Nerve Block
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteo Arthritis Knee
The Role of Vitamin K on Knee Osteoarthritis Outcomes
The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most…
- Trial name
- NCT06385275
- Testing
- Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Boston University
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Knee Osteoarthritis, Osteoarthritis (Knee)
Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if the VELYS Robotic-Assisted Solution (VRAS) device helps to improve outcomes from total knee replacement, when compared to regular non-robotic-assisted total knee replacement in the…
- Conditions
- Knee Osteoarthritis, Osteoarthritis (Knee), Osteo Arthritis of the Knee, Osteo Arthritis
- Trial name
- MARVEL Project (NCT07551856)
- Testing
- Robot-Assisted Functionally Aligned Total Knee Replacement, Manual Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 346 people
- Sponsor
- Golden Jubilee National Hospital
Osteo Arthritis Knee and Hip
Test-Retest Reliability of a Submaximal Exercise Test in Patients With Hip and Knee Osteoarthritis
The aim is to evaluate the test-retest reliability of the primary care-adapted Ekblom-Bak submaximal ergometer bicycle test in patients with hip- and/or knee osteoarthritis (OA).
- Trial name
- NCT07383740
- Testing
- Submaximal cycle ergometer test-retest
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Osteo Arthritis Knee, Knee Pain Chronic
Optimizing Pain Self-Management in Total Knee Arthroplasty
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee…
- Conditions
- Osteo Arthritis Knee, Knee Pain Chronic, Surgery
- Trial name
- NCT06038240
- Testing
- Savoring Meditation, Pain Self-Management and Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Osteo Arthritis of the Knee
Minimal-Incision Technique With Modified Tracking Pin Placement Versus Standard Robotic-Assisted Total Knee Arthroplasty
This randomized controlled trial will compare a minimal-incision and soft-tissue-preserving (MISI) technique with the standard surgical technique in patients undergoing robotic-assisted total knee arthroplasty for knee…
- Trial name
- MISI (NCT07765771)
- Testing
- MISI Robot-Assisted Total Knee Arthroplasty, Standard Robotic-Assisted Total Knee Arthroplasty
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Osteo Arthritis Knee, Pain, Postoperative
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
The utilization of intraoperative tranexamic acid (TXA), whether administered intravenously or orally, has become a standard practice in total joint arthroplasty (TJA).
- Trial name
- NCT06618820
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Campbell Clinic
Osteo Arthritis of the Knee
Research Title: Long Term Functional Outcome of a Single Hyaluronic Acid Injection in Improving Symptoms and Function in Patients With Knee Osteoarthritis - A Single-Arm Open-Label Study (DIART ONE).
This study aims to evaluate the effectiveness of a single HA injection in improving pain, function, and quality of life in patients with knee OA over a 12-month period.
- Trial name
- NCT07736781
- Testing
- Hyaluronic Acid (HA)
- Where
- Malaysia
- Volunteers
- 62 people
- Sponsor
- Universiti Sains Malaysia
Osteo Arthritis Knee
MISHA Post-Market Clinical Study
Prospective evaluation of the safety and effectiveness of the MISHA Knee System. The study will collect data on the procedural and long-term adverse events, WOMAC pain and function scores, KSS satisfaction, subsequent surgical…
- Trial name
- NCT06118892
- Testing
- MISHA Knee System
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Moximed
Osteo Arthritis of the Knee
Hydrogel Assessment for Local Treatment of Osteoarthritis
The study aims to evaluate the safety and tolerability of one intra-articular injection of Hydrogel OA 2% for the symptomatic treatment of osteoarthritis of the knee.
- Trial name
- HALO (NCT07516457)
- Testing
- Injection of Hydrogel OA 2%
- Where
- 3 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Allegro NV/SA
Osteo Arthritis Knee
Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle
Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics.
- Trial name
- ADIPENIGME (NCT05955976)
- Testing
- BIOPSY
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis
Gait Rehabilitation to Treat FastOA
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee
- Trial name
- NCT05848622
- Testing
- Real-time gait biofeedback
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteo Arthritis of the Knee
Comparison of the Effects of Two Different Exercise Programs on Femoral Cartilage Thickness and Clinical Parameters in Individuals With Knee Osteoarthritis
Knee osteoarthritis (OA) is one of the most common joint disorders worldwide and is a leading cause of pain, limited mobility, and functional disability, particularly in the elderly population.
- Trial name
- NCT07657481
- Testing
- Quadriceps Plus Hip Strengthening Exercises, Quadriceps Strengthening Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Pamukkale University
Osteo Arthritis of the Knee, Obesity & Overweight
Alignment Techniques in TKA RCT
The purpose of this research study is to compare two different methods used to align the knee during a total knee arthroplasty (TKA): technology-assisted inverse kinematic alignment, and manual-instrumented gap balancing…
- Trial name
- NCT07646158
- Testing
- Technology-assisted inverse kinematic alignment TKA, Manual-instrumented gap balancing alignment TKA
- Volunteers
- 80 people
- Sponsor
- Jacob M. Elkins
Osteo Arthritis Knee, Knee Arthritis
Persona IQ Cohort Study
A prospective multicenter longitudinal cohort study of Zimmer Biomet (ZB) Persona IQ The Smart Knee which consists of the Persona Personalized Knee (PPK) System with mymobility® platform that is attempting to develop correlative…
- Conditions
- Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty
- Trial name
- NCT06089291
- Testing
- Persona IQ
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet