Clinical trials: Orthopedic Surgery
Physiological Stress
Physiologic Burden to the Surgeon During Orthopaedic Surgery
The investigator's plan to quantify the physiologic impact of orthopaedic surgery on the surgeon and operating team.
- Trial name
- NCT06180044
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Utah
Neurological Disorders, Orthopedic Disorders
A Model for Continuous Care of Fragile Patients
This observational study aims to monitor functional status and identify potential declines in the functioning of medically fragile patients with neurological and/or orthopedic conditions, representing an added value for ensuring…
- Conditions
- Neurological Disorders, Orthopedic Disorders, Functional Decline, Fragile and More Vulnerable
- Trial name
- AFTER (NCT07299344)
- Testing
- Telemedicine-Based Functional Monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Acute Pain, Orthopaedic Surgery
Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.
This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity…
- Trial name
- NCT07606911
- Testing
- liposomal bupivacaine, Normal Saline
- Where
- China
- Volunteers
- 668 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Bone Defect, Orthopedic
Evaluation of the Safety and Performance of the TriOSS®: A Retrospective Observational Study in Orthopaedic Area
This study aims to collect real-world clinical data to gather information on the performance and safety of the TriOSS® when used according to its intended purpose and current clinical applications.
- Trial name
- TriOSSOrto01 (NCT07087509)
- Where
- Portugal
- Volunteers
- 23 people
- Sponsor
- Bioceramed
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Regional Anesthesia Morbidity, Postoperative Pain
Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques
We will enroll patients submitted to feet elective orthopaedic surgery that require analgesia through continuous peripheral nerve block (CNPB) of the sciatic nerve.
- Trial name
- NCT02029404
- Testing
- Tibial nerve group, Tibial peroneal nerve group
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Cytotoxicity
Biological Evaluation of Orthopedic Materials: An In Vitro Study Using Patient-Derived Human Samples
The anterior cruciate ligament (ACL) is the primary stabilizer of the knee joint, and ACL injuries are highly prevalent, particularly among physically active and athletic individuals.
- Trial name
- RAISE (NCT07671521)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Stefano Zaffagnini
Lmbar Spine With Screws
AI Based Metal Artifact Reduction-PMAR
The study is going to enroll about 220 consecutive patients with screws in lumber spine after internal fixation surgery who underwent follow-up assessment using Incisive CT according to the department standard of care.
- Trial name
- NCT07619404
- Volunteers
- 220 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center
Adjuvants, Anesthesia, Subarachnoid Block
Intrathecal Nalbuphine Versus Intrathecal Tramadol in Subarachnoid Block for Lower Limb Orthopaedic Surgeries
This study compares the use of intrathecal nalbuphine versus intrathecal tramadol as adjuvant agents to local anaesthetics in subarachnoid block for lower-limb orthopaedic surgeries.
- Trial name
- NCT07294352
- Testing
- Intrathecal tramadol with spinal anesthsia, Intrathecal nalbuphine and spinal anesthesia
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Orthopedic Disorder
Testing of Mobile Monitoring System
We will complete a prospective, observational study comparing the accuracy of the mobile monitoring tool on identifying SSI compared to manual review.
- Trial name
- NCT04601376
- Testing
- Mobile Monitoring Tool
- Sponsor
- Stanford University
Post Operative Pain, Acute
A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery
Combogesic® 325 contains a combination of ibuprofen and acetaminophen. The purpose of this study is to compare the pain relief effects of Combogesic® 325mg and acetaminophen and to evaluate the safety of Combogesic® 325mg in…
- Trial name
- NCT07225140
- Testing
- Combogesic® tablets, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Pain, Postoperative
An Efficacy and Safety Study to Compare Fentanyl Ionsys and Routine Care With Intravenous (IV) Morphine Patient-controlled Analgesia (PCA) in Participants Who Have Undergone Elective Major Abdominal or Orthopedic Surgery
The purpose of this study is to evaluate the mobilization characteristics, clinical use, safety and Ease of Care (EOC) of a fentanyl Iontophoretic Transdermal Patient Controlled Analgesia (PCA) system (Ionsys) and morphine…
- Trial name
- NCT00766506
- Testing
- Fentanyl IONSYS, Morphine IV PCA
- Where
- 7 sites in United Kingdom
- Volunteers
- 108 people
- Sponsor
- Janssen-Cilag Ltd.
Pain
Cyclical Sighing for Pain
This is a single-site, two-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a 4-minute audio-recorded cyclical sighing intervention for orthopedic patients will be investigated relative to a 4-minute…
- Trial name
- NCT06292793
- Testing
- Pain Coping Information, Cyclical Sighing
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Florida State University
Orthopaedic Surgery
The Influence of Perioperative Strategies on the Extent of in Orthopaedic Prosthetic Surgery
To assess the extent of blood loss in prosthetic surgery, considering whether possible variables may influence, either positively or negatively, the extent of such loss.
- Trial name
- IPECO (NCT07500350)
- Where
- Italy
- Volunteers
- 1,683 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Orthopedic Disorder
Ultrasound-guided FICB for Proximal Femoral Osteotomy in Pediatric Patients
This prospective randomized controlled trial aims to examine the effect of fascia iliaca compartment block on the postoperative pain and opioid consumption in pediatric patients (3y≤ age <18y) who will undergo orthopedics surgery…
- Trial name
- NCT04570891
- Testing
- Ultrasound-guided fascia iliaca compartment block, Control
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Hospital
Functional Constipation (FC)
Implementation of Physical Therapy Protocol for Functional Constipation
The goal of this randomized controlled trial is to investigate the effects of standard medical treatment alone and the effects of adding different physiotherapy protocols to standard medical treatment on constipation severity…
- Trial name
- NCT07719504
- Testing
- Standard medical treatment, Maitland orthopedic manual therapy (MOMT), Russian current stimulation (ERS)
- Volunteers
- 60 people
- Sponsor
- Cairo University
Traumatic Vertebral Fractures, Compression Fractures of the Spine
Comparison of Three Treatment Strategies for Traumatic AO Type A1 Vertebral Fractures
This retrospective study evaluates three different treatment approaches used for traumatic AO Spine Type A1 (A1) vertebral fractures: orthopedic bracing, percutaneous vertebroplasty, and spinal arthrodesis.
- Conditions
- Traumatic Vertebral Fractures, Compression Fractures of the Spine, AO Type A1 Vertebral Fracture, Spinal Trauma
- Trial name
- TRAUMA-A1 (NCT07471568)
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- University of Valencia
Pain Management
Rectroclavicular Block in Orthopedic Surgey
The ultrasound-guided retroclavicular approach to the infraclavicular region (RAPTIR) brachial plexus block has gained popularity as a relatively easy-to-perform nerve block that provides reliable and dense anesthesia to the…
- Trial name
- NCT06406647
- Testing
- retrocalvicular block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- New Valley University
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