Clinical trials: Orthopedic Procedures
Regional Anesthesia Morbidity, Postoperative Pain
Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques
We will enroll patients submitted to feet elective orthopaedic surgery that require analgesia through continuous peripheral nerve block (CNPB) of the sciatic nerve.
- Trial name
- NCT02029404
- Testing
- Tibial nerve group, Tibial peroneal nerve group
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Functional Constipation (FC)
Implementation of Physical Therapy Protocol for Functional Constipation
The goal of this randomized controlled trial is to investigate the effects of standard medical treatment alone and the effects of adding different physiotherapy protocols to standard medical treatment on constipation severity…
- Trial name
- NCT07719504
- Testing
- Standard medical treatment, Maitland orthopedic manual therapy (MOMT), Russian current stimulation (ERS)
- Volunteers
- 60 people
- Sponsor
- Cairo University
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Any Chronic, Non-traumatic Orthopedic Condition
Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care
The goal of this clinical trial is to find out whether using an artificial intelligence (AI) tool called a Large Language Model (LLM) can help patients think more clearly about their symptoms and improve their trust and…
- Trial name
- NCT07022769
- Testing
- LLM-facilitated cognitive debiasing aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Sports Injury, Orthopedic Disorder
Training of Falling Techniques on Landing Mechanics
The overall purpose of this study is to quantify the effect and retention of one-week training of falling techniques on landing biomechanics associated with anterior cruciate ligament (ACL) loading compared to soft-landing…
- Conditions
- Sports Injury, Orthopedic Disorder, Knee Injuries, Anterior Cruciate Ligament Injuries
- Trial name
- NCT04768088
- Testing
- Falling Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Thromboembolism
REVIparin-BRIDging-in a General Practice Setting in GErmany
In view of the fact that little is known about the pre- and post-interventional coagulation management of phenprocoumon patients with reviparin at general practices in Germany, an observational study is being initiated to…
- Trial name
- REVIBRIDGE (NCT02579122)
- Where
- 11 sites in Germany
- Volunteers
- 77 people
- Sponsor
- Mylan Inc.
Orthopedic Procedures, Obesity
Effect of BMI on Postoperative Morbidities of Orthopaedic Procedures
Obesity is associated with poor surgical outcome and complications. The literature does not provide a comprehensive view on the effect of body mass index (BMI) on perioperative outcomes in orthopedic surgeries.
- Trial name
- BMIORTHO (NCT04827888)
- Testing
- Orthopaedic surgery
- Where
- Lebanon
- Volunteers
- 76,189 people
- Sponsor
- American University of Beirut Medical Center
Knee Osteoarthritis, Arthritis Knee
How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.
The use of periarticular injection and adductor canal block are well-established techniques used both in combination or in isolation in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthritis Knee, Knee Disease, Opioid Use
- Trial name
- TRUE KnORTH (NCT04648072)
- Testing
- Adductor Canal Block, Periarticular Injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Health Sciences North Research Institute
Pain, Postoperative, Orthopedic Procedures
A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain
The purpose of this small study was to investigate the safety and effectiveness of OROS hydromorphone HCI for the treatment of short-term, moderate to severe postoperative pain following total knee replacement surgery.
- Conditions
- Pain, Postoperative, Orthopedic Procedures, Analgesia
- Trial name
- NCT00411307
- Testing
- OROS hydromorphone HCI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alza Corporation, DE, USA
Anxiety, Depression
Optimizing Mental Health in Orthopedic Care
This study will utilize qualitative cross-sectional and quantitative longitudinal methods. In semi-structured interviews, orthopedic providers and patients with spine conditions will discuss their overall perspectives, specific…
- Conditions
- Anxiety, Depression, Back Pain, Neck Pain
- Trial name
- NCT05194722
- Testing
- Wysa mobile app
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hypovolemia, Hemorrhage
Trial of 6% HES130/0.4
The study shall evaluate the efficacy and safety of two different hydroxyethyl starch solutions (artificial colloids 6% HES130/0.4 and 6% HES70/0.5, Salinhes®) for intra-operative therapy of hypovolemia and maintenance of…
- Trial name
- NCT01010022
- Testing
- 6% hydroxyethyl starch 130/0.4, 6% hydroxyethyl starch 70/0.5 (Salinhes®)
- Where
- 7 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Fresenius Kabi Japan
Osteoarthritis, Cardiovascular Disease
Risk Factor Control Before Orthopedic Surgery
This trial is designed to determine the best preoperative management strategy for patients undergoing orthopedic surgery.
- Trial name
- OPTMIZE-OS (NCT01837069)
- Testing
- Metoprolol, Lisinopril, Atorvastatin
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- NYU Langone Health
Spinal Stenosis, Spondylolisthesis
Decompression vs. Fusion for Stable Degenerative Spondylolisthesis
The purpose of this study is to assess the feasibility of a full-scale multicenter randomized, controlled trial comparing the effectiveness of two surgical treatments for a condition associated with lumbar spinal stenosis called…
- Trial name
- NCT02348645
- Testing
- Spinal fusion, Spinal decompression
- Where
- 8 sites in Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Primary Spondylodiscitis, Pyogenic Spondylodiscitis
One Year Results of Managing Primary Spondylodiscitis
Primary spondylodiscitis is a severe infectious condition involving the spinal discs and adjacent vertebrae. It often causes significant back pain and requires careful management, typically involving long-term antibiotics and…
- Conditions
- Primary Spondylodiscitis, Pyogenic Spondylodiscitis, Spinal Infection
- Trial name
- NCT07509983
- Volunteers
- 50 people
- Sponsor
- Assiut University
Remimazolam, Orthopedic Procedures
Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Currently used drugs for monitored general anesthesia include propofol, midazolam, and dexmedetomidine. Each drug has different advantages and disadvantages.
- Conditions
- Remimazolam, Orthopedic Procedures, Sedatives, Anesthesia, Spinal
- Trial name
- NCT05379777
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Asan Medical Center
Blood Transfusion, Blood Transfusion, Autologous
A Study to Determine the Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Non-anemic Patients Who Are Undergoing Orthopedic, Heart and Blood Vessel, or Breast Reduction Surgery; Performed in Combination With a Procedure to Reduce Blood Loss During Surgery.
The purpose of this study is to determine the safety and effectiveness of epoetin alfa and whether epoetin alfa will enable self-donation of blood during an 11-day period before surgery (which is shorter than the conventional…
- Conditions
- Blood Transfusion, Blood Transfusion, Autologous, Orthopedic Procedures, Orthopedic Surgery
- Trial name
- NCT00270023
- Testing
- epoetin alfa
- Volunteers
- 112 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hip Fractures, Knee Arthroplasty
Continuous Spinal Anesthesia Versus Combined Spinal Epidural Block
In major orthopaedic surgery of the lower extremities both continuous spinal anesthesia (CSA) and combined spinal epidural anesthesia (CSE) are safe and reliable anaesthesia methods.
- Conditions
- Hip Fractures, Knee Arthroplasty, Femur Fracture
- Trial name
- Spinocath (NCT00616044)
- Testing
- continuous spinal anesthesia, Spinocath a catheter for continuous spinal anesthesia, combined spinal epidural anesthesia
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Diabetes Mellitus, Surgical Procedure, Unspecified
DRIVE - Perioperative Period
This study will investigate if the HbA1c result before surgery which assesses glucose control over the longer term, can accurately predict what happens to the glucose levels and glucose profile following surgery.
- Trial name
- DRIVE-Periop (NCT04033705)
- Testing
- Freestyle Libre Pro glucose sensor
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Hallux Rigidus, Orthopedic Disorder
Risk for Reoperation After First MTP Joint Arthrodesis
We will screen all first metatarsophalangeal joint arthrodeses performed between 2010 and 2022 in Helsinki University Hospital. Information about demographics and additional diagnoses will be yielded from data pool of medical…
- Conditions
- Hallux Rigidus, Orthopedic Disorder, Surgery, Complication of Surgical Procedure
- Trial name
- NCT05795127
- Testing
- First metatarsophalangeal joint arthrodesis
- Where
- Finland
- Volunteers
- 1,213 people
- Sponsor
- Hospital District of Helsinki and Uusimaa