Clinical trials: Organoids
Colorectal Cancer
Precision Chemotherapy Based on Organoid Drug Sensitivity for Colorectal Cancer
The purpose of this study is to investigate whether chemotherapy guided by patient-derived tumor organoid drug test can improve the outcomes of stage IV colorectal cancer.
- Trial name
- NCT05832398
- Testing
- FOLFOX , FOLFIRI or FOLFOXIRI regimens, FOLFOX or CapeOX regimens
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pancreatic Cancer
Pharmacotyping of Pancreatic Patient-derived Organoids
EUS-FNB samples will be used for organoid cultures, which will be co-cultured with cancer associated fibroblasts derived from the surrounding stroma of the lesion.
- Trial name
- NCT05196334
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev Hospital
Neoadjuvant Therapy
The Clinical Efficacy of Drug Sensitive Neoadjuvant Chemotherapy Based on Organoid Versus Traditional Neoadjuvant Chemotherapy in Advanced Rectal Cancer
This is a prospective multicenter randomized controlled trial study. According to the enrollment criteria, patients with locally advanced rectal cancer who need neoadjuvant therapy before radical surgery were randomly divided…
- Trial name
- NCT05352165
- Testing
- standard long-term therapy, FOLFOX and standard long-term radiotherapy, FOLFIRI and standard long-term radiotherapy
- Volunteers
- 192 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Advanced Leiomyosarcoma
A Trial for Advanced Leiomyosarcoma With Human Organoid-guided Personalized Efficacy
This study is a prospective single arm multicenter intervention study aimed at evaluating the feasibility of using organoid drug sensitivity results to guide first-line treatment of advanced leiomyosarcoma.
- Trial name
- LMS-HOPE (NCT07405346)
- Testing
- treatment based on the results of drug sensitivity analysis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Cancer
Prospective Primary Human Lungcancer Organoids to Predict Treatment Response
Organoids are generated from tumor biopsies, taken during a standard procedure. and are a collection of organ-specific cell types that are able to self-organize in-vitro in a manner similar to the in-vivo situation (3D).
- Trial name
- Organoids lung (NCT04859166)
- Testing
- Organoids
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Extensive-stage Small Cell Lung Cancer (ES-SCLC), Extensive-stage Small Cell Lung Cancer (SCLC)
Organoid-guided vs Topotecan Therapy in Relapsed Extensive-Stage Small Cell Lung Cancer
This study aims to provide personalized treatment options for patients with extensive-stage small cell lung cancer (SCLC) whose disease has worsened after initial chemotherapy.
- Conditions
- Extensive-stage Small Cell Lung Cancer (ES-SCLC), Extensive-stage Small Cell Lung Cancer (SCLC), Small Cell Lung Cancer ( SCLC )
- Trial name
- NCT07106528
- Testing
- Organoid Drug Sensitivity Testing-Guided Therapy, Topotecan
- Volunteers
- 128 people
- Sponsor
- Peking Union Medical College Hospital
Eye Abnormalities
Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes.
- Trial name
- OrganoEye (NCT06408701)
- Testing
- Blood sampling
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Endometrial Cancer
Generation of Endometrial Carcinoma Organoids
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice.
- Trial name
- organoids endo (NCT07258186)
- Testing
- Generation of organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Regina Elena Cancer Institute
Radiation Enteritis, Inflammatory Bowel Diseases
Preclinical Evaluation of Multimodal Therapeutic Strategies in Intestinal Irradiation and Inflammatory Bowel Disease From Organoids
This study is carried out in patients with IBD and healthy subjects requiring ileocolonoscopy as part of routine care (disease monitoring or polyp/colon cancer screening).
- Trial name
- INTRUST (NCT05425901)
- Testing
- biopsy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
T3c Diabetes
The Use of Islet Organoids in the Treatment of Pancreatic Surgery-related Diabetes
The purpose of this clinical trial is to verify the safety and effectiveness of autologous islet organoids transplantation after in vitro expansion for the treatment of pancreatogenic diabetes.
- Trial name
- NCT06415643
- Testing
- Islet organoids transplantation
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Zhejiang University
Triple Negative Breast Cancer, Organoid
Establishment of an ex Vivo Tumor Collection of Triple-negative Breast Cancers in Order to Validate the Interest of Innovative Therapies and the Search for Predictive Biomarkers of Response to Treatment
Initially described in 2009 on LGR5 positive stem cells from intestine, organoids correspond to a 3D cell culture that preserves the organization and part of the initial function of the organ from which the cells were derived.
- Trial name
- TRIPLEX (NCT05404321)
- Testing
- Establishment of ex vivo breast cancer organoid models
- Where
- France
- Volunteers
- 163 people
- Sponsor
- Centre Francois Baclesse
Gynecologic Cancer, Organoid
Construction of Gynecological Tumor Organoids
This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.
- Trial name
- NCT06155370
- Testing
- construction of organoids from gynecological tumor
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer
The Culture of Advanced/Recurrent/Metastatic Colorectal Cancer Organoids and Drug Screening
The study aims to establish an organoids platform and apply them to screen drugs for advanced/recurrent/metastatic colorectal cancer patients.
- Trial name
- NCT05304741
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing University Cancer Hospital
Sarcoma, Melanoma
Using QPOP to Predict Treatment for Sarcomas and Melanomas
This is a multi-cohort proof of concept study involving patients with sarcomas or melanomas. Patient models, both two- and three-dimensional, will be derived from tumour samples.
- Trial name
- NCT04986748
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National Cancer Centre, Singapore
Ovarian Cancer
Patients Derived Organoids as a Promising Tool to Tailor Ovarian Cancer Therapies (PANDORA).
The association of clinical, pathogenesis and mutational profile of patients affected by ovarian cancer have improved the armamentarium of therapies available for medical doctors.
- Trial name
- PANDORA (NCT06229522)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Hepatocellular Carcinoma Resectable
Drug Sensitivity Testing-Based Tumor Organoids to Guide Adjuvant Therapy After Hepatectomy for Primary Liver Cancer
This is a single-center, prospective, non-randomized, open-label, phase II clinical trial aiming to evaluate the efficacy and feasibility of using patient-derived tumor organoid drug sensitivity testing (ODST) to guide…
- Trial name
- NCT07363356
- Testing
- Organoid Drug Sensitivity Testing-Guided Therapy
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Endometrial Cancer, Lynch Syndrome
Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome
Study Goal: This pilot study wants to find out if using a menstrual cup can be a good, non-invasive way to collect samples from the lining of the uterus (called the endometrium) to help screen for endometrial cancer.
- Conditions
- Endometrial Cancer, Lynch Syndrome, Screening, Early Detection of Cancer
- Trial name
- SCREEN-CUP (NCT07220239)
- Testing
- Menstrual cup use
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jessica D. St. Laurent, MD
PDAC - Pancreatic Ductal Adenocarcinoma
Functional, Personalised and Integrated Profiling of Biopsied Pancreatic Tumours (CancerProfile by FNB)
Pancreatic ductal adenocarcinoma (PDAC) has the poorest prognosis of all digestive cancers due to lack of early diagnosis and limited response to treatment.
- Trial name
- NCT06666803
- Testing
- FNB sampling, blood sampling
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- IHU Strasbourg
Hepatocellular Carcinoma
Construction of a Recurrence Risk Prediction Model for Liver Resection Based on Drug Sensitivity of Patient-derived Hepatocellular Carcinoma Organoid
Liver cancer is the sixth most common malignant tumor worldwide and the third leading cause of cancer-related deaths. China is a high-risk area for liver cancer, accounting for approximately 55% of primary liver cancer worldwide.
- Trial name
- NCT06699524
- Testing
- in vitro （chemotherapy）, Adjuvant TACE（Adjuvant Transarterial Chemoembolization）
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Shen Feng
Primary Sclerosing Cholangitis, PSC
Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients
The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.
- Conditions
- Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma
- Trial name
- NCT04753996
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic