Clinical trials: Organ Transplant
Infection in Solid Organ Transplant Recipients, Complications of Organ Transplant
Respiratory Viral Infections in Pediatric Transplantation
A retrospective cohort of solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients will be assembled to determine the incidence of respiratory viral infections diagnosed during an inpatient admission…
- Conditions
- Infection in Solid Organ Transplant Recipients, Complications of Organ Transplant, Respiratory Viral Infection
- Trial name
- NCT02260596
- Where
- United States
- Volunteers
- 2,669 people
- Sponsor
- Duke University
Covid19, SARS-CoV Infection
Prevalence and Outcome of SARS-CoV-2 Infection & COVID-19 in Transplant Recipients: The COVITRA Study
This project will provide novel data using a large cohort of more than 3000 transplanted patients. Risk and protective factors for SARS-CoV-2 infection and COVID-19 disease severity will be identified.
- Conditions
- Covid19, SARS-CoV Infection, Transplantation Infection
- Trial name
- COVITRA (NCT04579471)
- Testing
- SARS-CoV-2 IgG
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Student, Organ Donation
The Effect of Peer-Guided Education on Organ Donation on Organ Donation Attitude
This research will be conducted to determine the effect of peer-guided organ donation education given to anesthesia students on their attitudes towards organ donation.
- Conditions
- Student, Organ Donation, Attitude
- Trial name
- NCT07663981
- Testing
- Peer-led education on organ donation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Rectocele, Pelvic Organ Prolapse
Fat Injection for Rectocele Treatment: A Novel Approach
This clinical trial aims to evaluate the effectiveness of autologous fat grafting as a novel treatment for rectocele, a condition characterized by the herniation of rectal tissue into the posterior vaginal wall.
- Conditions
- Rectocele, Pelvic Organ Prolapse, Obstructive Defecation Syndrome
- Trial name
- NCT06604702
- Testing
- Autologous Fat Injection for Rectocele
- Volunteers
- 25 people
- Sponsor
- Cairo University
Hematopoietic Organs; Disorder
Probiotic Use in Children Undergoing Hematopoietic Stem Cell Transplantation (HSCT)
Primary Objective: 1. To evaluate the safety of orally administered Lactobacillus plantarum strains 299 and 299v, a probiotic, in patients undergoing allogeneic myeloablative HSCT, as measured by incidence of Lactobacillus…
- Trial name
- NCT01010867
- Testing
- Lactobacillus plantarum strains 299 and 299v
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Hepatitis C, Hepatitis C Virus Infection, Response to Therapy of
Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor
This trial will be done in participants who undergo transplantation of heart, kidney or lung at University of California, San Diego (UCSD) and receive a hepatitis C infected donor organ.
- Trial name
- NCT04596475
- Testing
- glecaprevir/pibrentasvir (GLE/PIB)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Cytomegalovirus (CMV) Infection, Kidney Transplant Recipient
Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission
Donor organs often carry latent Cytomegalovirus (CMV) infection that may be transmitted to the recipient. The goal of this clinical trial is to determine the safety of SYN002 treatment during Ex-Vivo Organ Perfusion (EVOP) in…
- Trial name
- RESPECT-CMV (NCT07488481)
- Testing
- SYN002
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Zoster; Herpes
Zoster Vaccine to Enhance Protection Against Zoster in Solid-organ Transplantation
Shingles is caused by the same virus that causes chickenpox. After someone has chickenpox, the virus stays in the body and can become active again later in life. This is called shingles.
- Trial name
- ZEST (NCT07443709)
- Testing
- Booster dose of the recombinant zoster vaccine (RZV, Shingrix®)
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Oriol Manuel
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Tissue and Organ Procurement, Adolescent Behavior
Organ Donation Interventions Among High Students
The number of persons actively waiting on the national solid organ waiting list continues to rise while the number donating organs has failed to keep pace.
- Conditions
- Tissue and Organ Procurement, Adolescent Behavior, Communication
- Trial name
- NCT02585921
- Testing
- Video Interventions, Donation Discussion Education
- Where
- United States
- Volunteers
- 872 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Prone Position, Donors
Prone vs Supine Position in Potential Organ Donors: Multicenter Clinical Trial
Background and justification: In Argentina, 9,650 people are on the organ transplant waiting list, including 290 who require a lung transplant.
- Conditions
- Prone Position, Donors, Lung Procurement, Tissue Donors
- Trial name
- PRODONAR (NCT07251777)
- Testing
- Prone position
- Where
- Argentina
- Volunteers
- 254 people
- Sponsor
- Hospital de Alta Complejidad del Bicentenario Esteban Echeverría
Infection Due to Resistant Organism
FMT for MDRO Colonization in Solid Organ Transplant
This is a pilot feasibility study to determine whether fecal microbiota transplantation (FMT) can suppress or reverse gastrointestinal carriage of MDROs in hospitalized solid organ transplant recipients with a history of one or…
- Trial name
- FMT (NCT02816437)
- Testing
- OpenBiome Fecal Microbiota Transplantation retention enema
- Sponsor
- University of Miami
Organ Donation, Next of Kin
Bernese Next of Kin Survey Following Organ Donation Request
6 to 18 months after organ donation request a next of kin survey using a standardized questionnaire was conducted.
- Conditions
- Organ Donation, Next of Kin, Post Traumatic Stress Disorder
- Trial name
- NCT03612024
- Testing
- questionnaire
- Where
- Switzerland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Immunodeficiency Secondary to Organ Transplantation
Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation
Three different white adipose tissue-related disorders, whether due to its excess (obesity), absence (lipoatrophies) or aberrant distribution (lipodystrophies), are paradoxically able to induce metabolic insulin resistance…
- Trial name
- IL-7tran (NCT01414660)
- Testing
- transplantation
- Where
- 5 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Lille
Kidney Transplant, Renal Transplant
Predictive Accuracy of Machine Perfusion for Kidney Transplant Outcomes in Germany
Kidney transplantation remains the only definitive treatment for end-stage renal disease, yet the increasing use of extended criteria donor (ECD) kidneys heightens the risk of ischemia-reperfusion injury, particularly under…
- Conditions
- Kidney Transplant, Renal Transplant, Organ Preservation
- Trial name
- PRE-MAP-Kidney (NCT07348874)
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Liver Transplant Rejection
The TOGETHER Project - Liver
To validate the use of a RNAseq-based peripheral blood assay in liver transplant recipients when correlated to liver biopsy results.
- Trial name
- TOGETHER (NCT03874286)
- Testing
- Liver Transplant
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Mayo Clinic
Infection in Solid Organ Transplant Recipients
The Incidence and Risk Factors for Clostridioides Difficle Infection in Solid Organ Transplant Recipients
2.1. Study Objectives Primary Objective(s) Identify the incidence and risk of CDI within one year after kidney, liver, and/or pancreas transplant Secondary Objective(s) Identify the risk factors for recurrent CDI post-transplant…
- Trial name
- NCT04637321
- Testing
- Solid organ transplant
- Where
- United States
- Volunteers
- 585 people
- Sponsor
- Methodist Health System
Infection in Solid Organ Transplant Recipients
Pneumococcal Conjugate Vaccine 13 (Prevnar13®) in Children Who Are Solid Organ Transplant Recipients (SOT)
The purpose of this study is to determine the safety and long-term immunogenicity of the 13-Valent Pneumococcal Conjugate vaccine in children who are solid organ transplant recipients.
- Trial name
- NCT01527591
- Testing
- Pneumococcal Conjugate Vaccine 13 (PCV13)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Organ Transplant Rejection
Clinical Study of Microchimerism and cfDNA as Biomarkers for Acute Rejection After Organ Transplantation
Organ transplantation has become an effective therapy for patients with end-stage organ failure at present. Rejection is still the most common cause of early dysfunction after organ transplantation.
- Trial name
- CSMCDTITAROT (NCT03255265)
- Testing
- no interventions
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Fuzhou General Hospital
Organ Donation
Understanding Decision Making in the Intensive Care Unit: a National Study
Given how central Substitute Decision Makers (SDMs) are to the process leading to end of life decisions and sometimes, organ donation, it is striking how poorly understood this decision-making process is.
- Trial name
- NCT03850847
- Testing
- Step 1: Semi-structured Interviews, Step 2: National Telephone Survey
- Where
- 9 sites in Canada
- Volunteers
- 292 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)