Clinical trials: Organ Dysfunction Syndrome
Sepsis, Multiple Organ Dysfunction Syndrome
Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis
Eligible patients will receive either AP or matching placebo in a double blind, randomized design and following a 2:1 ratio. All medication will be given in addition to standard care for sepsis patients.
- Trial name
- NCT00430859
- Testing
- Alkaline Phosphatase
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 37 people
- Sponsor
- AM-Pharma
Acute Aortic Syndrome, Aortic Dissection Type A
Protective Effect of Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- PANDA (NCT05339529)
- Testing
- Thymosin Alpha1, 28A-Glycine-28B-L-Arginine-28C-L-Glutamic Acid-28D-L-Alanine-28E-L-Proline-28F-L-Alanine-28G-L-Asparagine-, Blank control
- Where
- 15 sites in China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Multiple Organ Dysfunction Syndrome
Tolerance and Safety of a Duodenal Probe Monitoring the Microcirculation
For Intensive Care Units (ICU) patients, Multiple Organ Dysfunction Syndrome (MODS) is a very common complication yielding high morbidity and mortality.
- Trial name
- MC Monitor (NCT02246036)
- Testing
- APD probe
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- Advanced Perfusion Diagnostics
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Septic Shock
Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Septic shock is a potentially life-threatening condition that can result in multi-organ dysfunction syndrome (MODS) and mortality.
- Trial name
- SSAIL (NCT02317549)
- Testing
- LB1148
- Where
- 34 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Leading BioSciences, Inc
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Systemic Inflammatory Response Syndrome, C.Surgical Procedure; Cardiac
Studying Complement Inhibition in Complex Cardiac Surgery
The trial enrolls patients undergoing a complex cardiac surgery. The primary goal of the trial is to evaluate the pharmacodynamic dose response relationship of the monoclonal antibody IFX-1 in these patients.
- Trial name
- CARDIAC (NCT02866825)
- Testing
- IFX-1
- Where
- 10 sites in Germany
- Volunteers
- 116 people
- Sponsor
- InflaRx GmbH
Aortic Dissection, Aortic Dissection Aneurysm
Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- NCT06966687
- Testing
- Ulinastatin and Thymosin α1, Ulinastatin only
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Endotoxemia
Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- VIHE (NCT01100996)
- Testing
- control enteral nutrition, enriched enteral feeding
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Clostridioides Difficile Infection, Stool Microbiome
Bezlotoxumab Yielded Outcomes by Addressing Personalized Needs in Clostridioides Difficile Infection
Previous data have shown that integrated information from single nucleotide polymorphisms (SNPs) of the host DNA, interleukin 8 (IL-8) and the enrichment of the stool microbiome can indicate the patients with infection by…
- Conditions
- Clostridioides Difficile Infection, Stool Microbiome, Organ Dysfunction Syndrome, Clostridioides Difficile Infection Recurrence
- Trial name
- BEYOND (NCT05304715)
- Testing
- Bezlotoxumab, Normal saline 0.9% or 5% dextrose water
- Where
- 11 sites in Greece
- Volunteers
- 44 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction
Urgency, frequency and incomplete emptying are the key symptoms of lower urinary tract dysfunction, including bladder pain syndrome/interstitial cystitis, and overactive bladder syndrome.
- Conditions
- Prostatic Hyperplasia, Urinary Bladder Neck Obstruction, Cystitis, Interstitial
- Trial name
- NCT01482676
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Aortic Syndrome, Aortopathy
Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year…
- Trial name
- PANDA (NCT04699279)
- Testing
- Rosuvastatin 10mg
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Maternal sepsIs
Selective Lipopolysaccharide Hemosorption in Maternal Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million. The prevalence and frequency of obstetric sepsis are quite pronounced.
- Trial name
- MINERVA (NCT05711901)
- Testing
- Efferon LPS
- Where
- 7 sites in Russia
- Volunteers
- 30 people
- Sponsor
- Efferon JSC
Intraabdominal Hypertension, Multi-Organ Disorder
Correlation Between Intra-abdominal Pressure, Biomarkers of Bacterial Translocation and Intestinal Wall Damage
Main scientific hypotheses of the project: 1. The level of intestinal microflora translocation markers and biomarkers of intestinal wall damage the in the blood serum correlates with the level of intra-abdominal pressure…
- Conditions
- Intraabdominal Hypertension, Multi-Organ Disorder, Translocation Syndrome
- Trial name
- NCT06221293
- Testing
- immunoenzyme analysis
- Where
- 5 sites in Kazakhstan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Sepsis, Severe Infection
Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators
This is a prospective observational study involving adult patients with severe infection who are admitted to the intensive care unit (ICU). Severe infection and sepsis are major causes of death worldwide.
- Conditions
- Sepsis, Severe Infection, Multiple Organ Dysfunction Syndrome, Critical Illness
- Trial name
- MPR-PPI-SPMs (NCT07353970)
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Methylprednisolone, Glucocorticoid
Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial)
This study is designed to evaluate the effects of glucocorticoid(GC) on improving post-operative organ dysfunction in patients with acute type A aortic dissection(aTAAD).
- Conditions
- Methylprednisolone, Glucocorticoid, Aortic Dissection, Organ Dysfunction
- Trial name
- NCT05329740
- Testing
- Methylprednisolone Injection
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Shanghai Zhongshan Hospital