Clinical trials: Oral Potentially Malignant Disorder
Oral Cancer
Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions
Evaluation of the metformin drug effect as a drug that found to improve the quality of tissues, decrease signs \& symptoms of cancer, and decrease histo-pathological criteria of dysplasia.
- Trial name
- NCT03684707
- Testing
- Metformin Hcl 500Mg 24Hr Sa Tab, starch tablet
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
The Importance of Mucosal Screening in the Prevention of Oral Cancer.
Patients attending the Department of Oral Mucosal and Periodontal Diseases at the University Dental Center of the Medical University of Warsaw who provide written informed consent will be invited to participate in the study.
- Conditions
- OPMD, Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer, Oral Potentially Malignant Lesions, Leukoplakia Oral
- Trial name
- NCT07682883
- Testing
- Fluorescent oral examination (FOE), Conventional oral examination
- Where
- Poland
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Leukoplakia, Oral
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach
This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.
- Trial name
- NCT04858100
- Testing
- Surgical excision of the lesion, Wait and see approach
- Where
- 2 sites in Italy
- Volunteers
- 310 people
- Sponsor
- University of Milan
Oral Squamous Cell Carcinoma
Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma
This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions)…
- Trial name
- NCT05821179
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Cancer, Oral Cavity Cancer
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
The primary goal of this study is to see if photodynamic therapy (PDT) is effective for treatment of lesions in the oral cavity which have high risk of becoming oral cancer.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Leukoplakia, Oral Lichen Planus
- Trial name
- NCT06876038
- Testing
- 5-Amino Levulinic Acid
- Where
- 2 sites in India
- Volunteers
- 65 people
- Sponsor
- University of Massachusetts, Boston
Oral Squamous Cell Carcinomas, Oral Potentially Malignant Disorder
Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell Carcinoma
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and OPMD) counterparts by scRNAseq in OSCC patients.
- Trial name
- HOPES (NCT07579507)
- Testing
- Biospecimen, Blood sampling
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Leon Berard
Oral Potentially Malignant Disorders, Oral Cancer
Predictive Value of GOCCLES® Device for Early Diagnosis of Oral Potentially Malignant Disorders
Oral potentially malignant disorders (OPMDs) are chronic pathologies which can suffer dysplastic alterations and evolve into oral cancer.
- Trial name
- NCT05562375
- Testing
- GOCCLES, Toluidine blue stain, Biopsy
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Universidad Rey Juan Carlos
Oral Potentially Malignant Disorders, Alcohol Drinking
Role of the Dentist in the Control of the Alcoholic Habit in Patients with Potentially Malignant Oral Lesions
Introduction: Alcohol is the most consumed psychoactive substance, its consumption is very prevalent and there is a low perception of the risk it poses in our society.
- Trial name
- ALCODENT (NCT04584333)
- Testing
- Brief intervention
- Where
- Spain
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Oral Submucous Fibrosis
Efficacy of Curcumin in Oral Submucous Fibrosis
The purpose of the study is to determine whether the formulations of curcumin will effect the clinical signs and symptoms and histopathological features in patients with clinical stage 2 oral submucous fibrosis (OSMF).
- Trial name
- ECOSMF (NCT03511261)
- Testing
- 10% Curcumin mucoadhesive gel, Curcumin capsules 500mg, 5% curcumin mucoadhesive gel + Curcumin capsules 250 mg
- Where
- India
- Volunteers
- 200 people
- Sponsor
- H.K.E.S's S.Nijalingappa Institute of Dental Science and Research
Cancer Screening, Oral Cancer
Application and Validation of a Smartphone-based Deep Learning System for Oral Potentially Malignant Disorders and Oral Cancer Screening
The goal of this clinical trial is to learn if smartphone-based deep learning system works to accurately detect oral potentially malignant disorders and oral cancer in adults.
- Conditions
- Cancer Screening, Oral Cancer, Oral Potentially Malignant Disorders
- Trial name
- NCT06862414
- Testing
- Smartphone-based deep learning system
- Where
- Taiwan
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
NBI for Early Diagnosis of OPMD/OSCC
Early detection - possibly at its pre-malignant stages (Oral Potentially Malignant Disorders, OPMD) - with periodic surveillance is thus fundamental for limiting disease burden, hopefully reducing the incidence of advanced stages…
- Trial name
- NBI_Oral (NCT06438939)
- Testing
- Biopsy for diagnostical purposes
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Cardarelli Hospital
Oral Potentially Malignant Disorders, Oral Cavity Squamous Cell Carcinoma
Artificial Intelligence for the Diagnosis of Oral Lesions
Squamous cell carcinomas of the upper aerodigestive tract are among the most common cancers worldwide, with the oral cavity being the most frequent site.
- Trial name
- AID-OraL (NCT07529769)
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oral Epithelial Dysplasia
The Relationship Between Interferon Status and HPV Infection in Patients With Oral Epithelial Dysplasia
This is an interventional prospective randomized clinical trial (RCT) in parallel groups. The sample size is 74 patients who were randomly divided into two groups depending on the surgical intervention used.
- Trial name
- NCT07678281
- Testing
- Excision of the OED site with a fiber laser, Excision of the OED site with a scalpel
- Where
- Russia
- Volunteers
- 74 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Precancerous Conditions
Photographic Evidence of Oral Precancerous Lesions in Current Tobacco and Areca Nut Users Improves Their Quit Rates
The success of tobacco and areca nut cessation programs in individuals with Oral Potentially Malignant Disorders (OPMDs) is imperative for risk reduction and prevention of oral cancer.
- Trial name
- NCT05215860
- Testing
- Tobacco and areca nut cessation counselling with standard management for Oral Potentially Malignant Disorders, visual exposure to personal intraoral photographs of oral lesions at baseline and review
- Where
- India
- Volunteers
- 200 people
- Sponsor
- All India Institute of Medical Sciences
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Oral Lichen Planus, Oral Leukoplakia
Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders
Oral potentially malignant disorders (OPMDs) are mucosal lesions that carry a risk of malignant transformation into oral cancer.
- Conditions
- Oral Lichen Planus, Oral Leukoplakia, Traumatic Ulcer of Oral Mucosa, Erythroleukoplakia of Mouth
- Trial name
- NCT07318922
- Testing
- Toluidine blue staining of the lesion and cytological smears
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Oral Potentially Malignant Lesions, Oral Cancer
Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)
The study is designed to measure serum and salivary CYFRA21-1 levels using enzyme linked immunosorbent assay (ELISA) in patients with oral malignancy, oral potentially malignant lesions, and control subjects to evaluate the…
- Trial name
- CYFRA21-1 (NCT03686020)
- Testing
- Enzyme Linked Immunosorbent assay (ELISA)
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Squamous Cell Carcinoma of the Oral Cavity, Leukoplakia Oral
Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
Recent studies estimated that 15 to 20% of all cancers in humans are associated with viruses. Among oral cancer about 90% are oral squamous cell carcinomas (OSCC).
- Trial name
- INECOC (NCT01636544)
- Testing
- contralateral healthy tissue biopsy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Pasteur