Clinical trials: Oral Melatonin
Alveolar Bone Loss
Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
Background: Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and secreted by the pineal gland and other organs, such as the retina, bone marrow, and intestines in a circadian pattern.
- Trial name
- NCT04229719
- Testing
- N-acetyl-5-methoxytryptamine
- Where
- Iraq
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Diseases
The Adjunctive Use of Melatonin Therapy in the Treatment of Obese Periodontitis Patients (Clinical and Immunological Study).
To evaluate the effect of adjunctive systemic administration of melatonin to mechanical non- surgical periodontal therapy in obese patients with periodontitis.
- Trial name
- NCT04788979
- Testing
- Melatonin 5Mg Oral Tablet
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- University of Baghdad
Periimplantitis
Application of Local Melatonin in Peri-implantitis
A randomized clinical trial was carried out in patients affected by peri-implantitis with a follow-up of 60 days. Melatonin 1.9 mg or placebo was applied locally to the peri-implant defect after nonsurgical debridement.
- Trial name
- MEL19 (NCT06816277)
- Testing
- Desbridamiento de periimplantitis, Aplicación de melatonina
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Diabetes Mellitus, Periodontitis
Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis
Background and aim: Hyperinflammatory host response associated with diabetes mellitus significantly provokes periodontal tissue destruction.
- Conditions
- Diabetes Mellitus, Periodontitis, Melatonin, Matrix Metalloproteinases
- Trial name
- NCT05870358
- Testing
- Melatonin 3 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Yağmur Saraç Gül
Bioavailability
Oral Bioavailability of Two Melatonin Supplements
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life.
- Trial name
- MELFENIL (NCT05835258)
- Testing
- Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Impacted Mandibular Third Molar
The Effect of Topical Application of Hyaluronic Acid and Melatonin Mixture Following Surgical Extraction of Impacted Mandibular Third Molars .
This randomized controlled clinical trial aims to evaluate the clinical and radiographical effects of the application of a mixture of hyaluronic acid and melatonin after surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07735806
- Testing
- Hyaluronic acid and Melatonin mixture, Gel foam
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Sleep Disorders, Circadian Rhythm
The Efficacy of Melatonin in the Burning Mouth Syndrome
Burning mouth ( BMS) syndrome is the oral disorder characterized by an intraoral burning sensation for which no medical or dental cause can be found.
- Trial name
- BMS (NCT03788733)
- Testing
- Melatonin 3 mg
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Dexmedetomidine, Melatonin
Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium
This study aims to compare the effect of dexmedetomidine infusion and oral melatonin on preventing delirium in intensive care unit (ICU) patients.
- Conditions
- Dexmedetomidine, Melatonin, Delirium
- Trial name
- NCT06076668
- Testing
- Dexmedetomidine, Melatonin 3 MG, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Oral, Melatonin
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
- Conditions
- Oral, Melatonin, Pregabalin, Postoperative Pain
- Trial name
- NCT07344467
- Testing
- Melatonin capsule, Pregabalin capsule
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Burning Mouth Syndrome
Efficacy of Melatonin in Burning Mouth Syndrome (BMS)
The purpose of this study is to determine whether melatonin is effective in the treatment of burning mouth syndrome (BMS).
- Trial name
- BMS2013 (NCT02580734)
- Testing
- melatonin
- Volunteers
- 20 people
- Sponsor
- University of Milan
Oral Squamous Cell Carcinoma, Neoadjuvant Chemotherapy
Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma
Backgrounds Squamous cell carcinoma of the oral cancer (OSCC) is the sixth most common malignancy. Surgery is the mainstay of treatment for oral cancers.
- Trial name
- NCT04137627
- Testing
- Melatonin 20 MG Oral Capsule
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Preoperative Anxiety
Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery
Preoperative anxiety is a common issue in pediatric anesthesia. Children often experience anxiety and uneasiness due to uncertain outcomes.
- Trial name
- NCT06489327
- Testing
- melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg
- Where
- 2 sites in Egypt, Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction
Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Reconstruction (ACLR) is a common orthopedic procedure that is accompanied by moderate to severe postoperative pain and is primarily performed on an outpatient basis.
- Trial name
- ACLR (NCT07096635)
- Testing
- Melatonin, Starch tablets
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Periodontitis
New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin
The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the…
- Trial name
- HAMELDENT (NCT03656484)
- Testing
- Tetracycline-Metronidazole (TM) group, TM-Melatonin-Hyaluronic acid (TM-MHa) group
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- Concordia Dent Srl
Biological Availability
Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally (MELATONIN)
Sleep disorders represent an important public health problem that cause important personal problems, absenteeism and considerable health costs.
- Trial name
- MELATONIN (NCT03951025)
- Testing
- Melatonin oral administration, Melatonin sublingual administration
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Dental Implant, Immediate Dental Implant Placement
Melatonin Effect on Immediate Dental Implants in the Posterior Mandible
This pilot randomized controlled clinical trial aims to evaluate the feasibility, clinical safety, and preliminary radiographic osteogenic effects of applying topical 1% w/w melatonin gel during immediate implant placement in the…
- Conditions
- Dental Implant, Immediate Dental Implant Placement, Alveolar Bone Loss, Bone Density
- Trial name
- NCT07869030
- Testing
- 1% w/w Melatonin Gel, Standard Immediate Dental Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Future University in Egypt
Effect of Drug, Anxiety
Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy
Comparison between the effect of oral Melatonin and Hydroxyzine for Preventing Preoperative Anxiety in pediatric Patients Undergoing Adenotonsillectomy
- Trial name
- NCT05680584
- Testing
- Melatonin 3 MG, Hydroxyzine Pill
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Minia University
Pharmacokinetics of Melatonin
Pharmacokinetics of Melatonin Niosomes Oral Gel in Healthy Volunteers
Melatonin is an endogenous hormone. It is able to promote nighttime sleeping and could induce sleep at daytime in adult and children with the nonpainful diagnostic procedure.
- Trial name
- NCT02845778
- Testing
- Melatonin
- Where
- Thailand
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Jaw, Edentulous, Partially, Bone Resorption
Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw
The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla…
- Conditions
- Jaw, Edentulous, Partially, Bone Resorption, Dental Implant Failure
- Trial name
- UV-MEL-IMPLANT (NCT07853976)
- Testing
- UV-Photofunctionalized Dental Implant, Conventional Dental Implant
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Parkinson's Disease, Nocturia
Melatonin for Nocturia in Parkinson's Disease
This is an an open label clinical trial of sustained-release Melatonin 2mg once daily for 12 weeks in patients with Parkinsons's Disease reporting nocturia, defined as getting up regularly at night > twice to pass urine.
- Trial name
- NCT02359448
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London