Clinical trials: Oral Contraception, active
Endometriotic Cyst of Ovary
Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy
Endometriosis is a chronic inflammatory disease that affects approximately 10-15% of women of reproductive age. Symptoms include dysmenorrhoea, chronic pelvic pain, dyspareunia and infertility.
- Trial name
- NCT05487092
- Testing
- Letrozole
- Where
- 5 sites in Hong Kong
- Volunteers
- 194 people
- Sponsor
- The University of Hong Kong
Menstrual Cycle, Resistance Training
Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes
The goal of this clinical trial is to assess the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes.
- Conditions
- Menstrual Cycle, Resistance Training, Neuromuscular Function, Female Athlete
- Trial name
- MENSES (NCT06679491)
- Testing
- Resistance periodized training program (N-PF), Resistance peioridized training program (N-PL), Continuous resistance training program (C)
- Where
- Reunion
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universite de La Reunion
Contraception
Arterial Vascular Effects of Estetrol-drospirenone Combined Oral Contraceptive Pill
The goals of this clinical trial are to investigate the effect of the estetrol (E4)-drospirenone combined oral contraceptive (COC) pill on flow-mediated dilatation (FMD) of the brachial artery and pulse wave velocity (PWV), in…
- Trial name
- NCT07536763
- Testing
- Estetrol-drospirenone, Ethinylestradiol-levonorgestrel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Dr. Hang Wun Raymond Li
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Female Participants With Obesity or Overweight
The main purpose of this study is to evaluate how eloralintide (LY3841136) effects the way the body processes oral contraceptive in female participants with obesity or overweight.
- Trial name
- NCT07808060
- Testing
- Eloralintide, Combined oral contraceptive
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Female Contraception
Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small.
- Trial name
- WOMEN&More (NCT06394999)
- Testing
- Mifepristone 50 mg
- Where
- 14 sites in Netherlands
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Emergency Contraception
Etonogestrel (ENG) Implant Insertion for Emergency Contraception With Oral Levonorgestrel (LNG) vs Placebo
Intrauterine devices (IUDs) are highly effective to prevent pregnancy when used for emergency contraception (following unprotected intercourse in the last 3 days), but data are lacking for people who desire an etonogestrel (ENG)…
- Trial name
- NCT06162611
- Testing
- Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg
- Where
- United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Lori Gawron
Overweight, Obesity
A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight
The purpose of this clinical study is to find out if NNC0662-0419 is safe and effective to be taken together with other medicines, like birth control pills, and emptying of the stomach in women not able to become pregnant living…
- Trial name
- NCT07525791
- Testing
- NNC0662-0419, Oral contraceptive, Acetaminophen
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Participants
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
This study will measure the effects of multiple doses of AZD6234, AZD9550 and a combination of AZD9550 and AZD6234 given as injection(s) on pharmacokinetics (PK) of combined oral contraceptive (CoC) ethinyl estradiol…
- Trial name
- NCT07013643
- Testing
- AZD6234, Ethinyl estradiol/Levonorgestrel (EE/LEVO), Acetaminophen (APAP)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pregnancy, HIV Infections
Phase 2b, Open Label, Multisite, Randomized Crossover Study of DPP Versus 2PR
To evaluate adherence to a single dual-prevention pill (DPP) compared with a two-pill regimen (2PR) for pre-exposure prophylaxis (PrEP) and pregnancy prevention in women without HIV.
- Trial name
- NCT07288190
- Testing
- DPP, 2PR, Free Choice
- Where
- 3 sites in Eswatini, Uganda and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- HIV Prevention Trials Network
Contraception, Pharmacogenomic Drug Interaction
Oral Contraceptive Pill (OCP) Pharmacogenomics
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these…
- Trial name
- NCT06334315
- Testing
- Desogestrel / Ethinyl Estradiol Pill
- Where
- 2 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Yale University
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Endometriosis
Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
Endometriosis is a painful disorder of the uterus affecting 6-10% of women of childbearing age. Endometriosis affects daily activities, social relationships, sexuality and sexual activity, and mental health.
- Trial name
- ELARIS EM-COC (NCT04333576)
- Testing
- Elagolix, Combined Oral Contraceptive
- Where
- 179 sites in United States, Puerto Rico
- Volunteers
- 800 people
- Sponsor
- AbbVie
Estrogen, Cardiovascular Diseases
Estrogen and Microvascular Function
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: give one blood draw of 5 mL have one Dexa Scan taken to measure adipose and muscle mass have a camera…
- Conditions
- Estrogen, Cardiovascular Diseases, Microvasculature, Oral Contraceptive Use
- Trial name
- NCT06043310
- Testing
- Nω-nitro-L-arginine methyl ester (L-NAME), Acetylcholine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Anemia
Levonorgestrel Intrauterine System Effects on Hemoglobin and Serum Ferritin Among Anemic Women in Kenya
Women with mild/moderate anemia who are seeking contraception will be randomized to a levonorgestrel (LNG) intrauterine system (IUS) or an LNG/ethinyl estradiol (EE)/ferrous fumarate combined oral contraceptive (COC) regimen and…
- Trial name
- LISA (NCT05233956)
- Testing
- LNG IUS, COCs
- Where
- Kenya
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- FHI 360
Menstrual Cycle, Oral Contraceptive Use
Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes
A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of…
- Conditions
- Menstrual Cycle, Oral Contraceptive Use, Athlete
- Trial name
- Flow2Perform (NCT07591818)
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Contraception Use
Sildosin as a Male Contraceptive Non Hormonal
In all, 200 healthy, sexually active, fertile male candidates will be assigned 100 in silodosin group and 100 in placebo group. Males using other contraceptive methods will be excluded.
- Trial name
- NCT07195097
- Testing
- Oral intake of sildosin
- Volunteers
- 200 people
- Sponsor
- Benha University
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
The Focus of the Study is to Investigate Reversible Effects of Combined Oral Contraceptive Use on Serotonergic Neurotransmission, Healthy Adult Females
Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission
The goal of this study is to learn about potential reversible effects of combined oral contraceptive (COC) use on the serotonergic brain system.
- Trial name
- REVERSE (NCT07511439)
- Testing
- Discontinuation of 2nd generation combined oral contraceptive use, Continuation of 2nd generation combined oral contraceptive use
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Ovary Syndrome (PCOS)
Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS
This cross-sectional study aims to compare the effectiveness of oral contraceptives, oral progesterone (didrogesterone), and inositol in regulating menstrual cycles among women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07242131
- Testing
- Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Advanced Malignancies
A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies
This drug-drug interaction (DDI) study aims to evaluate the impact of pelabresib at steady-state plasma concentrations on the pharmacokinetic (PK) profile of A) a single dose of repaglinide and a single dose of midazolam, and B)…
- Trial name
- NCT07340190
- Testing
- pelabresib, repaglinide, midazolam
- Where
- 6 sites in France, Italy and 1 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals