Clinical trials: Optical Coherence Tomography (OCT)
Non-arteritic Ischemic Optic Neuropathy, Optic Disk Drusen
NA-AION Risk Factors: New Perspectives
The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION.
- Trial name
- NARROW (NCT05305079)
- Where
- 20 sites in United States, Australia and 7 more
- Volunteers
- 179 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-Melanoma Skin Cancer (NMSC)
Optical Frequency Domain Imaging for Non-melanoma Skin Cancers
The purpose of this research study is to find out if a non-invasive imaging device called Optical Frequency Domain Imaging (OFDI) can help doctors to see the tissue and blood vessels that are related to non-melanoma skin cancers.
- Trial name
- OFDI (NCT01662713)
- Testing
- OFDI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Pituitary Adenoma
Long-term Follow up for Retinal Vascular Changes After Endoscopic Endonasal Pituitary Surgery.
This study investigates the retinal vascular features, using optical coherence tomography angiography, in patients during one year's follow up after the endoscopic endonasal surgery to remove an intra-suprasellar pituitary…
- Trial name
- NCT04546386
- Testing
- Endoscopic endonasal pituitary surgery
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Federico II University
Coronary Heart Disease, Diabetes Mellitus
Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT
Diabetic patients are prone to a diffuse and rapidly progressive form of atherosclerosis. Both clinical and angiographic outcomes following percutaneous coronary intervention (PCI) are poor in patients with DM compared with those…
- Trial name
- DM-COVER (NCT01021930)
- Testing
- Polymer-based sirolimus-eluting stent(Cypher stent ) and Polymer-free paclitaxel-eluting stent (YinYi stent)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Harbin Medical University
Severe Asthma
Phenotyping Asthma for Bronchial Thermoplasty
This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients.
- Trial name
- NCT03435237
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Sturge-Weber Syndrome
Biomarker Development in Sturge-Weber Syndrome
This is a study of 40 individuals with Sturge-Weber Syndrome (SWS) brain and/or eye involvement. It will examine the test-retest reliability of the following clinical tests: 1. Quantitative EEG 2. Transcranial Doppler 3.
- Trial name
- Pilot (NCT01345305)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Age-Related Macular Degeneration, Macular Degeneration
Repeated Eye Injections of Aflibercept for Treatment of Wet Age Related Macular Degeneration
To evaluate the visual outcome and number of injections required during an optical coherence tomography (OCT)-guided treat and extend regimen with intravitreal aflibercept for treatment of subfoveal neovascular age-related…
- Trial name
- ATLAS (NCT01773954)
- Testing
- Intravitreal Aflibercept Injection
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- MidAtlantic Retina
Diabetic Macular Edema
Changes in Inflammatory Biomarkers Including Soluble CD14 and Hyperreflective Foci in DME Patients Treated With Aflibercept (FORESIGHT)
This study evaluates the effect of aflibercept on the change of cytokines incluing sCD14, MCP-1, IL-6, and ICAM-1 in the aqueous humor of DME patients.
- Trial name
- FORESIGHT (NCT03780361)
- Testing
- Aflibercept Injection
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Hyewon Chung
Age Related Macular Degeneration
Correlation Between Visual Field Defects on FORESEE HOME and on Optical Coherence Tomography in Choroidal Neovascularization Subjects
The FORESEE HOME is used in the recent years to detect Age-related Macular Degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal…
- Trial name
- NCT00884637
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Notal Vision Ltd.
Scar
Laser Treated Scars and Optical Coherence Tomography (OCT)
The purpose of this research study is to learn about the effects of the 2940 nm Erbium: Yttrium-Aluminum-Garnet (Er:YAG) laser on treating surgical scar using optical coherence tomography, a medical imaging device.
- Trial name
- NCT05166395
- Testing
- Er:YAG laser
- Where
- United States
- Sponsor
- University of Miami
Macular Edema, Cystoid
Effect of Prophylactic Ketorolac on CME After Cataract Surgery
The study will evaluate the efficacy of prophylactic administration of the topical nonsteroidal anti-inflammatory drug (NSAID) ketorolac tromethamine 0.5% (Acular®) on cystoid macular edema (CME) in patients having undergone…
- Trial name
- NCT00335439
- Testing
- ketorolac tromethamine 0.5% (Acular®)
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Queen's University
Keratitis Bacterial, Keratitis Fungal
Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment
As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis…
- Trial name
- VICTORIA (NCT05620264)
- Testing
- Tear Sample Probe
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Johannes Kepler University of Linz
Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
OCT in Fuchs' Dystrophy
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
- Trial name
- NCT04258787
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Lung Neoplasm
Exploration of Optical Coherence Tomography-Guided Transbronchial Biopsy in Peripheral Pulmonary Lesions
In this prospective analysis, investigators collected and evaluated data from patients who underwent TBB at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital.
- Trial name
- OCTGTBIPPL (NCT06419114)
- Testing
- Optical Coherence Tomography
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sichuan Provincial People's Hospital
Coronary Artery Disease
Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up
The objective of the study is to evaluate the process of early re-endothelialization of the Coroflex® ISAR Drug-eluting stent compared with the Ultimaster® Drug-eluting stent
- Trial name
- NCT02785237
- Testing
- Coroflex® ISAR Drug-eluting stent, Ultimaster® Drug-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Branch Retinal Vein Occlusion
Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT
The aim of the trial is to evaluate the efficacy and safety of intravitreal injections of ranibizumab for the treatment of macular edema due to BRVO if the re-treatment regimen is guided by morphological macular changes detected…
- Trial name
- RabOCT (NCT01968239)
- Testing
- Ranibizumab
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Leipzig
Myocardial Infarction, Optical Coherence Tomography
Optical Coherence Tomography Examination in Acute Myocardial Infarction
Different plaque morphology may have an important effect on the prognosis of acute myocardial infarction (AMI), as recent studies show that patients with plaque rupture have a significantly higher risk of cardiac events compared…
- Trial name
- OCTAMI (NCT03593928)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
OctA .FFA Findings in DR
Optical Coherence Tomography Angiography and in Fluorescein Angiography in Diabetic Retinopathy
Diabetic retinopathy (DR) is the leading cause of decreased vision in working age people. Patients with DR can develop macular edema and proliferative retinopathy which are major causes of visual impairment [1].
- Trial name
- NCT05190965
- Testing
- OCTAngiography .FFangiography
- Volunteers
- 40 people
- Sponsor
- Assiut University
Coronary Artery Disease, Optical Coherence Tomography
A Single Center Registry of Coronary OCT
This registry started January 1,2020 to collect patients who recieve coronary OCT imaging in Hainan General Hospital.All enrolled patients will receive 1 year followed-up.
- Conditions
- Coronary Artery Disease, Optical Coherence Tomography, Registry
- Trial name
- NCT04855500
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hainan People's Hospital
Atherosclerosis, Diabetes
Effects on Re-endothelialisation With Bydureon Treatment in Type 2 Diabetes Subjects
The aim of the study is to use Exenatide long-acting release (LAR) [Bydureon] to minimize vascular remodeling and neointima formation after Percutaneous Coronary Intervention (PCI) and to accelerate stent endothelialisation.
- Conditions
- Atherosclerosis, Diabetes, Restenosis
- Trial name
- Rebuild (NCT02621489)
- Testing
- Bydureon, Humulin kwickpen, Metformin
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Karolinska Institutet
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