Clinical trials: Opioid Use, Unspecified
Opioid Use, Unspecified
Application of Economics & Social Psychology to Improve Opioid Prescribing Safety (AESOPS): R21 Pilot Phase
There is a lack of evidence that long-term opioid use offers benefit for noncancer pain and an abundance of evidence of harm. The objective of the R21 pilot phase of the Application of Economics \& Social psychology to improve…
- Trial name
- AESOPS (NCT03773484)
- Testing
- Opioid naive, At-risk for long term use, Long-term opioid recipient
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Southern California
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid Use, Unspecified
EHR-Based Medication Complete Communication Strategy to Promote Safe Opioid Use
The purpose of this study is to test the effectiveness of an electronic health record based strategy in promoting safe use of opioid medications after an Emergency Department (ED) visit.
- Trial name
- EMC2 (NCT02431793)
- Testing
- EMC2 Strategy, SMS Text Reminders
- Where
- United States
- Volunteers
- 652 people
- Sponsor
- Northwestern University
Opioid Use, Unspecified, Pain, Postoperative
Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery
Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery.
- Trial name
- NCT05662371
- Testing
- Nociception Level monitor (NOL), Standard care
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified
A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements
This study is a prospective, randomized, double-blind clinical trial evaluating whether intraoperative intravenous lidocaine infusion (IVLI) reduces opioid requirements and improves postoperative pain control in children…
- Conditions
- Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation
- Trial name
- NCT07552766
- Testing
- Lidocaine Infusion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nemours Children's Clinic
Opioid Use, Unspecified, Bariatric Surgery Candidate
Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids
The goal of this clinical trial is to compare Opioid Free and Opioid Based Anaesthesia in patients undergoing sleeve gastrectomy.
- Trial name
- NCT05752799
- Testing
- Opioid Free Anaesthesia, Opioid based anesthesia
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Opioid Use, Opioid Use, Unspecified
Patient Utilization of Opioid Destruction Bags in the Post-op Period
This is a study on how patients use and store opioid pain medications at home after surgery and what happens to left over pills when patients are done taking them.
- Conditions
- Opioid Use, Opioid Use, Unspecified, Patient Empowerment, Total Knee Arthoplasty
- Trial name
- NCT05875857
- Testing
- Opioid destruction education
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Nebraska
Opioid Use, Unspecified
Investigating Interventions to Reduce Residual Opioids in the Home Following Legitimate Opioid Prescribing in Children.
The overall objective of this study is to evaluate strategies to reduce unused opioids prescribed for pediatric acute post-surgical pain management.
- Trial name
- NCT04219397
- Testing
- Medication take back, Medication home disposal
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Indiana University
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Opioid Use, Unspecified
the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block
The purpose of the study is to determine if perineural dexmedetomidine can provide increased prolongation of analgesia when compared to perineural dexamethasone in patients receiving regional block for shoulder surgery.
- Trial name
- NCT02653144
- Testing
- Ropivacaine, Dexmedetomidine, Dexamethasone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Montefiore Medical Center
Pain, Acute, Opioid Use, Unspecified
EMR Defaults to Nudge Opioid Prescribing
The investigators conducted a prospective, block-randomized study to determine whether and to what extent changes in the default settings in the electronic medical record (EMR) affect opioid prescriptions for patients discharged…
- Trial name
- NCT04155229
- Testing
- Default settings for opioid prescriptions (acetaminophen/hydrocodone, oxycodone, acetaminophen/oxycodone)
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Opioid Use, Unspecified
Educational Video on Pain Management and Subsequent Opioid Use After Cesarean Delivery
This is a randomized controlled trial assessing the utility of an educational video on pain management after a cesarean section to reduce opioid use.
- Trial name
- NCT03959969
- Testing
- Educational video, Standard of care, Ibuprofen
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Anxiety, Chronic Pain
Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic
The purpose of this study is to characterize and improve controlled substance, carisoprodol and tramadol use in an internal medicine residents' clinic.
- Conditions
- Anxiety, Chronic Pain, Opioid Use, Unspecified
- Trial name
- NCT02244099
- Testing
- Controlled Substance
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Pain, Postoperative, Pain, Acute
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement
The purpose of this study is to determine whether administration of a pectoral nerve blocks (Pecs I and II) with 0.25% bupivacaine are more effective as compared to placebo to provide analgesia for cardiac implantable electronic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chest, Pain
- Trial name
- NCT05283980
- Testing
- 0.25% Bupivacaine
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Opioid Use, Unspecified
Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients
Hair analysis is a well-established and important tool in both forensic and clinical context. When it comes to the interpretation of positive hair analysis results, reliable and comprehensive reference data is essential.
- Trial name
- NCT05740657
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Recurrence Tumor, Opioid Use, Unspecified
Analgesia aNd caNcer recUrrence Lung cAncer Resection
The choice of analgesia after cancer surgery may play a role in the onset of recurrence, particularly opioids seem to play a role in the immune system by promoting cancer cell proliferation and migration.
- Conditions
- Recurrence Tumor, Opioid Use, Unspecified, Analgesia, Thoracic Surgery
- Trial name
- NCT04656769
- Testing
- Peridural analgesia
- Where
- Italy
- Volunteers
- 382 people
- Sponsor
- University of Turin, Italy
Knee Arthroplasty, Total, Analgesia
Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing
This will be a randomized controlled clinical trial in patients who have undergone primary unilateral total knee arthroplasty at Brigham and Women's Faulkner Hospital, Brigham and Women's Hospital and University of Chicago…
- Conditions
- Knee Arthroplasty, Total, Analgesia, Opioid Use, Unspecified
- Trial name
- NCT04564729
- Testing
- Shared Decision Making
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Brigham and Women's Hospital
Advanced Cancer, Opioid Use, Unspecified
Paracetamol for Cancer Pain
Randomised, double-blind placebo controlled cross-over trial Main goal: Optimize the medical pain treatment for patients with advanced cancer disease Study goal: Measure paracetamol's additional analgesic effect in a situation…
- Trial name
- NCT01313247
- Testing
- paracetamol
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Haraldsplass Deaconess Hospital
Chronic Low Back Pain, Opioid Use, Unspecified
The Effects of Cognitive Behavioral Therapy and Transcranial Current Stimulation (tDCS) on Chronic Lower Back Pain
The primary objective of this study is to evaluate the effects of cognitive-behavioral therapy in combination with transcranial direct current stimulation in (1) improving pain and functionality, (2) reducing severity of opioid…
- Trial name
- NCT02483468
- Testing
- Cognitive Behavioral Therapy for Pain, Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Medical University of South Carolina