Clinical trials: Opioid Induced Hyperalgesia
Chronic Low Back Pain, Opioid-induced Hyperalgesia
Opiate-Induced Tolerance & Hyperalgesia in Pain Patients
Opiates such as morphine are the cornerstone medications for the treatment of moderate to severe pain. Recent evidence suggests that pain patients on chronic opioid therapy become more sensitive to pain (hyperalgesia) over time.
- Trial name
- NCT00246532
- Testing
- Morphine
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Compliance, Chronic Pain
Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain
In a small, well-characterized sample of prescription opioid abusers (POAs) with chronic pain and on buprenorphine therapy, this study will investigate the utility and feasibility of two novel tracer compounds, and in combination…
- Trial name
- NCT02276989
- Testing
- acetazolamide, Quinine, Riboflavin
- Where
- United States
- Sponsor
- Georgetown University
Pain, Hyperalgesia
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an…
- Conditions
- Pain, Hyperalgesia, Inflammatory Response
- Trial name
- NCT01301079
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Tooth Extractions
Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery
Wisdom teeth removal under general anaesthesia is usually suitable for ambulatory surgery. The choice of opioid in dental day surgery is based on the need for a rapid and full recovery, as well as less morphine administration.
- Trial name
- SUF-REM-DDS (NCT01139671)
- Testing
- Remifentanil
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Clermont-Ferrand
Neuropathic Pain
Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
Clinical, psychophysical, behavioral or genetic factor will predict the response to opioid treatment in patients with chronic neuropathic pain.
- Trial name
- NCT01914042
- Testing
- Morphine, Milnacipran
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rambam Health Care Campus
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Hyperalgesia
Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol
Opioid Induced Hyperalgesia (OIH) is an entity than has been demonstrated in healthy volunteers and in animal models. Is defined as an increase in the perception to painful stimuli, increasing the opioid requirements and…
- Trial name
- NCT02934763
- Testing
- Propranolol, Saline
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Pain, Head and Neck Disorder
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery
Opioid tolerance in the perioperative period is inevitable especially with ultra-short acting agents such as remifentanil. Existing evidence had shown that opioid induced hyperalgesia due to neuroplastic changes in the central as…
- Trial name
- NCT02416752
- Testing
- Remifentanil, choice of intra-operative opioids were left to the discretion of anesthesiologist
- Where
- Singapore
- Volunteers
- 222 people
- Sponsor
- Singapore General Hospital
Cancer Patients
A Comparison of the Perception of a Needle Injection Pain Between Cancer Patients Receiving Opioid Therapy Versus Opioid-naive Patients
Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids. In humans, the evidence of OIH is strong but conflicting.
- Trial name
- NCT01704469
- Testing
- The local anesthetic injection
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Chronic Pain, Chronic Pain Syndrome
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP).
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia
- Trial name
- STTEPP (NCT05603702)
- Testing
- Lacosamide
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Indiana University
Opioid-induced Hyperalgesia
Hyperalgesia in Methadone Patients: Can it be Treated?
In the proposed study, we will build upon our previous studies validating and characterizing hyperalgesia in MM samples to explore it's underlying mechanism from a pharmacological perspective.
- Trial name
- NCT00333242
- Testing
- dextromethorphan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy
Can Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?
The purpose of this study is to examine whether two clinically sensible dose regimen of fentanyl (low dose vs. high dose) lead to different pain scores as measured by the nonverbal rating scale (NRS) in healthy volunteers at 4.5…
- Trial name
- FentaOIH-V (NCT02252458)
- Testing
- Fentanyl
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain, Postoperative, Anesthesia
Comparison of Remifentanil-induced Postoperative Hyperalgesia Between Patients From Plain Area and Plateau Area
Purpose: 1. To compare the incidence of postoperative hyperalgesia induced by remifentanil in patients undergoing gynecological laparoscopic surgery in plateau and plain areas 2.
- Trial name
- NCT05028049
- Testing
- Sufentanil injection, Remifentanil Hydrochloride, plain areas
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Tianjin Medical University General Hospital
Hyperalgesia
Opioid-induced Hyperalgesia After Remifentanil Infusion
Remifentanil is a rapid-acting opioid which has been widely used in pain treatment during surgery for the last 15 years 1. Remifentanil is rapidly eliminated (minutes) from the body after end of infusion, and this makes it easily…
- Trial name
- NCT01702389
- Testing
- Remifentanil
- Where
- Norway
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pain, Anesthesia
Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients
Purpose: To explore and compare antihyperalgesic effects of butorphanol, flurbiprofen axetil, and a combination of both received before anesthesia induction.
- Trial name
- NCT02043366
- Testing
- Normal Saline, Butorphanol, Flurbiprofen axetil
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Tianjin Medical University General Hospital
Buprenorphine, Pain
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia
Evidence to support the effectiveness of ongoing opioid therapy for the treatment of chronic non-malignant pain is lacking. In fact, data suggest that patient outcomes improve when tapered off opioid analgesics.
- Trial name
- NCT03063905
- Testing
- Buprenorphine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Georgetown University
Opioid Dependence, Pain
The Effects of Minocycline in Opioid-maintained Patients
Opioids are the most commonly utilized pharmacological treatment for moderate to severe pain. However, their clinical value is hindered by the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT02359006
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Yale University
Chronic Pain
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
Managing pain in patients who abuse prescription opioids presents many challenges, including the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT01821430
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Ehlers-Danlos Syndrome, Craniocervical Syndrome
Opioid-Free Anesthesia for Patients With Joint Hypermobility Syndrome Undergoing Craneo-Cervical Fixation: A Case-series
Cranio-cervical instability (CCI) has been well identified in diseases regarding connective tissue, such as Ehlers-Danlos Syndrome/Hipermobility Type (EDS-HT).
- Trial name
- NCT04437589
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Servei Central d'Anestesiologia
Postoperative Hyperalgesia
Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids
To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group…
- Trial name
- NCT05234697
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University