Clinical trials: Opioid Craving
Opioid Use Disorder
A Mobile Executive Functioning Intervention for Momentary Craving in Opioid Use Disorders
Even when treated with methadone or buprenorphine maintenance, many people with opioid use disorder (OUD) continue to experience craving.
- Trial name
- NCT05086835
- Testing
- Working Memory Task, Visual Search Task
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mclean Hospital
Substance-Related Disorders
Resonance Breathing Intervention Opioid Use Disorder
This study aims to assess the feasibility of an intervention for the management of craving, stress, anxiety, and depression among people who use opioids via a resonance breathing smartphone app.
- Trial name
- NCT05830773
- Testing
- Resonance Breathing Exercises
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Decision Making
Craving & Decision-Making
Craving is the strong desire for something, such as for substances in drug addiction and food or other activities in everyday life.
- Trial name
- NCT06440577
- Testing
- Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Opioid-use Disorder, Medication Assisted Treatment
Minds and Mentors Program (MiMP)- R61
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of a twelve- week mindfulness based relapse prevention protocol in combination with peer mentoring in…
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
- Trial name
- MiMP (NCT04233671)
- Testing
- Mindfulness based relapse prevention and peer mentoring
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Opiate Addiction
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal…
- Trial name
- NCT02539823
- Testing
- CBD 400 mg, CBD 800 mg
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hurd,Yasmin, Ph.D.
Opioid-use Disorder, Heroin Abuse
Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings
The purpose of this research study is to test the effect of repetitive transcranial magnetic stimulation (rTMS) on opioid cravings among adult patients with Opioid Use Disorder.
- Conditions
- Opioid-use Disorder, Heroin Abuse, Craving, Transcranial Magnetic Stimulation
- Trial name
- NCT05074524
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nevada, Las Vegas
Opioid-use Disorder
Pain, Inflammation and Opioid Craving
The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder.
- Trial name
- NCT04190563
- Testing
- Pain De-Catastrophizing, Pain Education
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mclean Hospital
Misuse, Opioid
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
- Trial name
- NCT06200181
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Opioid Withdrawal, Opioid Use Disorder
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.
- Conditions
- Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
- Trial name
- NCT05027919
- Testing
- Hydromorphone, Naloxone + lofexidine pretreatment, Lofexidine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Opioid Withdrawal, Opioid Use Disorder
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
The primary objective of this trial is to measure changes in physiologic signals to quantify the status of the autonomic nervous system during opioid withdrawal and cravings.
- Trial name
- NCT06487533
- Testing
- EmbracePlus Smartwatch, Corti Sensor
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Spark Biomedical, Inc.
Psychiatry
NUTRItion-driven Detoxification of OPioid Addicted patiEnts
The NUTRIDOPE (NUTRItion-driven Detoxification of OPioid addicted patiEnts) study is a clinical trial that aims to investigate the role of pomegranate juice consumption by opioid-addicted patients under buprenorphine and…
- Trial name
- NUTRIDOPE (NCT05861544)
- Testing
- Pomegranate juice
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- Organization Against Drugs (ΟΚΑΝΑ)
Opioid-Related Disorders, Mobile Applications
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol use) to prevent relapse among patients receiving medication-assisted…
- Conditions
- Opioid-Related Disorders, Mobile Applications, Opiate Substitution Treatment, Magnetic Resonance Imaging
- Trial name
- NCT05336188
- Testing
- Smartphone
- Where
- United States
- Volunteers
- 336 people
- Sponsor
- University of Arkansas
Opioid Dependence, Cocaine Dependence
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.
- Trial name
- Goliath (NCT02935101)
- Testing
- Prednisolone
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Prof. Dominique de Quervain, MD
Alcohol Use Disorder, Alcoholism
fNIRs-based Neurofeedback to Reduce Relapse in pOUD/AUD
This study will examine the impact of functional near-infrared spectroscopy-based neurofeedback to a region within the brain's prefrontal cortex involved with self-regulation of resisting craving in alcohol use and prescription…
- Conditions
- Alcohol Use Disorder, Alcoholism, Prescription Drug Dependence, Opioid-use Disorder
- Trial name
- NCT03595293
- Testing
- fNIRs-based Neurofeedback
- Sponsor
- Milton S. Hershey Medical Center
Opioid-use Disorder, Depression, Anxiety
Transcranial Photobiomodulation for the Treatment of Opioid Cravings
The investigators wish to test the hypothesis that transcranial photobiomodulation (tPBM) (i.e., 4-minutes of 810nm near-infrared light at 250 mW/cm2 by LED to the forehead at F3 or F4 versus an indistinguishable placebo…
- Conditions
- Opioid-use Disorder, Depression, Anxiety, Craving
- Trial name
- NCT04417738
- Testing
- unilateral transcranial photobiomodulation, near infrared mode
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- MindLight, LLC
Opioid Dependence
Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)
To investigate the effects of cortisol on heroin craving and stress reaction in heroin addicted subjects Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication Study…
- Trial name
- Ghost-Basel (NCT01718964)
- Testing
- Cortisol 20 mg, Mannitol
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Prof. Dominique de Quervain, MD
Opioid-use Disorder
Opiate Craving Reduction Study Using Post-detox Patients on Suboxone and Use of TEAS as Adjunctive Treatment
Pilot study of 12 outpatients in early recovery from illicit drug use,post-detox and on buprenorphine-naloxone maintenance will be offered 12 TEAS adjunct treatments over 6 weeks(X2/week) to ascertain if they experience any…
- Trial name
- NCT02033746
- Testing
- Han's Acupoint Nerve Stimulator
- Where
- United States
- Sponsor
- Mclean Hospital
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Opioid Withdrawal, Opioid Craving
Oral Cannabidiol for Opioid Withdrawal
This pilot study will examine the safety of the cannabinoid cannabidiol (Epidiolex) in a human laboratory model of clinically relevant withdrawal.
- Conditions
- Opioid Withdrawal, Opioid Craving, Opioid Use Disorder
- Trial name
- NCT04238754
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University