Clinical trials: Opioid Consumption
Pain, Acute, Opioid Use
Femoral Triangle Block With Popliteal Plexus Block Versus Femoral Triangle Block Versus Adductor Canal Block for TKA
In this study we wish to investigate the analgesic effect 3 different nerve block regimes in patients following primary total knee arthroplasty (TKA).
- Conditions
- Pain, Acute, Opioid Use, Analgesia
- Trial name
- NCT04854395
- Testing
- Marcain 5 mg/ml
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Regionshospitalet Silkeborg
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Pain
Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty
Study will evaluate the effect of liposomal bupivacaine versus standard bupivacaine on physical therapy measures and pain scores as well as opiate consumption.
- Trial name
- NCT03182933
- Testing
- Peripheral Nerve Blockade, 10 meter walk test on post-operative day 1, In person and over the phone questionnaire
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Wisconsin, Madison
Pain, Postoperative, Opioid Use
Efect of Erector Spina Plane Block on Mastectomy
After breast cancer surgery, more than 60% of patients experience persistent pain.Although opioids are the main method of use in postoperative pain management, there are side effects such as constipation, sedation, respiratory…
- Trial name
- NCT04824300
- Testing
- erector spinae block
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Marmara University
Opioid Consumption, Demographic Data
Single-level and Two-level Serratus Posterior Superior Intercostal Plan Block (SPSIPB)
Breast cancer is the most common malignancy in women; one of the mainstays of breast cancer treatment is surgery, and modified radical mastectomy is one of the standard treatments.
- Trial name
- NCT06751407
- Testing
- Single level SPSIPB, Two-level SPSIPB
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Pain, Postoperative, Analgesic Effect
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty is a commonly performed orthopaedic surgery for the treatment of end-stage osteoarthritis when conservative management becomes ineffective.
- Conditions
- Pain, Postoperative, Analgesic Effect, Total Knee Arthroplasty, Liposomal Bupivacaine
- Trial name
- NCT06740214
- Testing
- 0.5% standard bupivacaine only, 1.33% liposomal bupivacaine with 0.5% standard bupivacaine, 1.33% liposomal bupivacaine only
- Where
- Hong Kong
- Volunteers
- 177 people
- Sponsor
- The University of Hong Kong
Postoperative Pain, Cholelithiasis
Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (gallbladder removal) is one of the most common abdominal operations performed worldwide. Despite its minimally invasive approach, up to half of patients experience notable postoperative pain, which…
- Trial name
- NCT07865455
- Testing
- Labetalol, Magnesium Sulfate, Lidocaine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pain, Postoperative
Efficacy And Safety Of Parecoxib IV/IM 40 Mg Vs Placebo Following Sub Muscular Breast Augmentation
The present study aims to compare the pre-emptive analgesic efficacy of parecoxib 40 mg IV/IM versus placebo on reducing postoperative acute pain following submuscular breast augmentation.
- Trial name
- NCT00435747
- Testing
- PARECOXIB SODIUM
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Opioid Use, Anesthesia Morbidity
Paragastric Autonomic Neural Blockade as Part of Combined Anesthesia.
To evaluate the effect of early autonomic blockade on the consumption of remifentanil and halogenated anesthesia in the intraoperative period during laparoscopic sleeve gastrectomy.
- Trial name
- NCT05668845
- Testing
- PG-ANB performed at the outset of LSG, PG-ANB performed at the end of the LSG
- Where
- Colombia
- Volunteers
- 79 people
- Sponsor
- Universidad Simón Bolívar
Methadone, Pain, Post Operative
Perioperative Methadone in Hip Fracture Patients
Postoperative analgesic treatment needs to be improved. Numerous studies suggest that a single dose of Methadone given during surgery significantly ameliorates postoperative pain and reduces postoperative opioid consumption.
- Conditions
- Methadone, Pain, Post Operative, Pain, Postoperative, Analgesics, Opioid
- Trial name
- NCT05581901
- Testing
- Methadone (Dose1), Methadone (Dose 2), Methadone (Dose 3)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- University of Southern Denmark
Anxiety, Opioid Consumption
Associations Between Analgesia Nociception Index and Preoperative Anxiety
The management and prediction of pain is one of the most crucial jobs for anesthetists. It has been shown that a patient's ability to remain calm during stressful situations is related to their post-surgical pain scores.
- Conditions
- Anxiety, Opioid Consumption, Cesarean Section
- Trial name
- PANIC (NCT04875572)
- Testing
- Analgesia Nociception Index (ANI) Monitor
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Opioid Abuse (Disorder), Opioid Analgesia
Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity
The goal of this clinical trial is to evaluate strategies for optimizing postoperative multimodal pain regimens and reducing opioid dependency in patients undergoing upper extremity surgery.
- Conditions
- Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption
- Trial name
- NCT07750639
- Testing
- Naproxen, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Laparoscopic Abdominal Surgeries
Effect of Low-dose Pregabalin Retard (82.5 mg) Versus Standard-dose Pregabalin Retard (165 mg) on Postoperative Pain and Opioid Consumption After Elective Laparoscopic Abdominal Surgery
The goal of this clinical trial is to detect whether pregabalin retard (82.5 mg or 165 mg) improves analgesia after elective laparoscopic abdominal surgery in adults. It will also evaluate the safety of both doses.
- Trial name
- NCT07456761
- Testing
- Pregabalin retard 82.5 mg, Pregabalin retard 165 mg
- Volunteers
- 80 people
- Sponsor
- South Egypt Cancer Institute
Postoperative Analgesia, Pain, Postoperative
Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection
Breast cancer is the most common type of cancer in women. Mastectomy and axillary lymph node disection are commonly performed as part of the cancer management. This surgery can cause significant postoperative pain.
- Conditions
- Postoperative Analgesia, Pain, Postoperative, Opioid Consumption
- Trial name
- NCT03341234
- Testing
- Bupivacaine, Saline, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ataturk University
Postoperative Pain, Total Hip Arthroplasty
Comparing Pericapsular Nerve Group Block with Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery
Total hip arthroplasty is a common surgical procedure aiming to improve mobility and quality of life in patients suffering from hip pain.
- Trial name
- NCT06059339
- Testing
- Procedure/Surgery: Regional Block Comparison Comparing postoperative pain and opioid consumption in groups
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Marmara University
Pelvic Organ Prolapse
Postoperative Opioid Consumption After Urogyneocologic Surgery
The purpose of this randomized controlled trial is to evaluate whether preoperative opioid education will reduce postoperative opioid consumption after urogynecologic surgeries.
- Trial name
- NCT03586219
- Testing
- Opioid-specific educational patient pamphlets
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- University of California, Irvine
Major Abdominal Surgery, Chronic Pain
Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants
The opioid crisis is a growing problem around the world, with prescription opioids being a major contributor to this crisis. They can be prescribed in different chronic and acute settings, such as surgery.
- Conditions
- Major Abdominal Surgery, Chronic Pain, Opioid Use
- Trial name
- POCAS (NCT05197465)
- Testing
- Questionnaires
- Where
- 2 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Postoperative Pain
Intravenous Acetaminophen/Ibuprofen Fixed-dose Combination on Postoperative Opioid Consumption
This prospective, randomized, double-blinded study is designed to evaluate the postoperative analgesic effect of the intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing video-assisted thoracic…
- Trial name
- NCT05366777
- Testing
- acetaminophen/ibuprofen fixed-dose combination, Saline
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
Spinal Surgery
Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery
The researchers are doing this study to find out whether giving methadone during spinal surgery helps manage pain in the first 72 hours after surgery better than other standard pain medications.
- Trial name
- NCT05417100
- Testing
- Methadone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital