Clinical trials: Ophthalmic, Healthy Eyes
Glaucoma, Open-Angle
Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects
Perimetry is a well-established method that is used to measure the visual field functions of humans. Commercially available products, such as the OCTOPUS 900 (Haag-Streit AG, Koeniz, Switzerland), are commonly used for assessing…
- Trial name
- NCT03325751
- Testing
- Visual field testing
- Where
- Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glaucoma, Open-Angle, Normal Tension Glaucoma
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects.
- Conditions
- Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT03870230
- Testing
- Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Dynamic Vessel Analyzer (DVA), Pattern Electroretinography (pERG)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Conjunctivitis, Bacterial
Safety and Tolerability of PRO-143 Ophthalmic Solution in Healthy Volunteers.
Study to evaluate the safety and tolerability of PRO-143 solution ophthalmic in healthy volunteers.
- Trial name
- PRO-143 (NCT03698045)
- Testing
- PRO-143 Ophthalmic Solution
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers
The purpose of this study is to evaluate the drug concentrations of AzaSite compared to Vigamox in tears of healthy volunteers
- Trial name
- NCT00575367
- Testing
- AzaSite (azithromycin ophthalmic solution), Vigamox (moxifloxacin hydrochloride ophthalmic solution)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Allergic Conjunctivitis
Safety Study of a Contact Lens With Ketotifen in Healthy, Normal Volunteers
The purpose of this study is to evaluate the safety of a novel contact lens in healthy normal volunteers
- Trial name
- NCT00569777
- Testing
- K-Lens (generic name not established) and Ketotifen
- Where
- 3 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Vistakon Pharmaceuticals
Healthy Adult Participants, Healthy Participants
Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep…
- Trial name
- CAP-TI (NCT07498270)
- Testing
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES), Anterior thalamic stimulation (TI-TES)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Subjects
Effect of Oat Compounds on Postprandial Glucose Response
In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
- Trial name
- NCT05177172
- Testing
- High beta glucans, Low beta glucans, Low beta glucans + low polar lipids
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Healhty
Study to Evaluate Safety, Tolerability and Pharmacokinetics of G01 Eye Drops in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of single and multiple ascending doses of G01 when administered as eye drops in healthy subjects.
- Trial name
- NCT07779902
- Testing
- G01 Eye Drops 100 µg/mL SAD, G01 Eye Drops 200 µg/mL SAD, G01 Eye Drops 400 µg/mL SAD
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qingdao WanMing BioCell Pharmaceutics Co.,Ltd.
Normal Diameter of Optic Nerve
Ultrasonographic Measurement of the Optic Nerve Sheath Diameter in the Taiwanese Healthy Volunteers
The investigators aimed to analyze the ONSD diameters and its associated factors in Taiwanese healthy volunteers. We plan to recruit 150 healthy volunteers aged more than 20 years old.
- Trial name
- NCT04600570
- Testing
- ultrasound
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Study of Comprehension and Execution of Medication Prescriptions in Parkinsonian Patients and Healthy Volunteers
Many patients with Parkinson's disease (Pd) don't respect medication prescriptions. Non-adherence is caused by several factors among which three play an important role: treatment complexity, cognitive decline, and…
- Trial name
- TACTIPARK (NCT03976505)
- Testing
- reading a table format prescription on a touch screen, reading a textual format prescription on a touch screen, filling a virtual pillbox displayed on the screen as prescribed in the prescription
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Retinal Disease, Healthy
Data Gathering for A10900
The objective of this study is to gather Optical Coherence Tomography (OCT) data on normal and diseased eyes
- Conditions
- Retinal Disease, Healthy, Glaucoma, Corneal Diseases
- Trial name
- NCT07149740
- Testing
- OCT
- Where
- 4 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve head (ONH) circulation has been shown in animals and…
- Trial name
- NCT00915226
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Volunteers, Sjögren's Syndrome
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a condition when the body's immune system attacks glands that produce fluids, such as the tear and saliva glands. This leads to dry eyes and a dry mouth.
- Trial name
- NCT06544642
- Testing
- ASP5502
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Open Angle Glaucoma, Ocular Hypertension
A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
This is a Phase I/II stage to investigate the safety, tolerability, and ocular hypotensive efficacy of TO-O-1001 in healthy volunteers and patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT05456724
- Testing
- TO-O-1001
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theratocular Biotek Co.
Raman Spectroscopy
Raman Scattering Spectroscopy to Measure Macular Pigment
This study will evaluate the ease and reliability of Raman scattering spectroscopy, a new technique to measure the amount of the pigment lutein in the retina, the light-sensitive tissue lining the back of the eye.
- Trial name
- NCT00060580
- Testing
- Raman scattering spectroscopy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Optic Papilla Edema
Determination of Normal Measures of Optic Nerve Sheath Diameter in Children
The purpose of this study is to measurement of optic nerve sheath diameter in children without intracranial pressure increase and determine the average optic nerve sheath diameters for healthy children.
- Trial name
- NCT03178760
- Testing
- Ultrasonic Measurement will be taken from optic nerve sheat diameter and compared-classified.
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Cukurova University
Healthy
Characterization of the Edge of Soft Contact Lens and Its Interaction With Ocular Surface
The goal of this study is to look at contact lens on the eye and its interaction with the eye during wearing.
- Trial name
- NCT00707291
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Miami