Clinical trials: Oncologic Diseases
Multiple Myeloma, Hematologic Diseases
Comparison of Geriatric Screening Methods in Newly Diagnosed Multiple Myeloma Patients
The purpose of this study is to compare clinical judgment and comprehensive geriatric assessment as screening tools for optimization of treatment for newly diagnosed elderly multiple myeloma patients.
- Trial name
- COMPASS (NCT02918695)
- Where
- 20 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rash, Systemic Treatments
Telemedicine Rash Evaluation and Assessment of Toxicity in Skin in Acute Oncology and Haematology Care: A Pilot Study
This study is being done to find out if video consultations (telemedicine) can be used to safely and effectively assess and manage skin problems caused by cancer treatments.
- Conditions
- Rash, Systemic Treatments, Tele-assessment
- Trial name
- TREATS (NCT07476807)
- Testing
- telem healthassessment
- Where
- Ireland
- Volunteers
- 25 people
- Sponsor
- Sligo General Hospital
Oral Mucositis, Chemotherapy-induced Oral Mucositis
Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis
Oral mucositis is a frequent and often debilitating complication of radiotherapy and chemotherapy, particularly in patients treated for head and neck cancers.
- Conditions
- Oral Mucositis, Chemotherapy-induced Oral Mucositis, Head and Neck Neoplasms
- Trial name
- OZOMUC (NCT07491536)
- Testing
- Gas Ozone Therapy, Biomimetic Oral Care Regimen
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Pavia
Gynecologic Cancer, Anemia
Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery)
Iron deficiency has been reported in approximately 35% of patients with a gynecologic malignancy. Blood transfusions are known to be immunosuppressive and carry immediate and long-term risks.
- Conditions
- Gynecologic Cancer, Anemia, Iron-deficiency
- Trial name
- FORGE II (NCT05407987)
- Testing
- Ferric derisomaltose
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- AHS Cancer Control Alberta
Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
EL CENTRO: Engaging Latinos in the Center of Cancer Treatment Options
The objective of this study is to improve the chemotherapy decision making process for Latinos with advanced gastrointestinal cancers.
- Conditions
- Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT03602885
- Testing
- Usual chemotherapy education (CE), Chemotherapy education intervention (CEI)
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Psychological Distress
Psychological Distress in Breast Cancer Patients: A Cross-Sectional Study in Iraq
This cross-sectional study aims to assess the psychological distress, including depression, anxiety, and stress, among breast cancer patients in Anbar, Iraq.
- Conditions
- Breast Cancer, Psychological Distress, Depression Anxiety Disorder, Stress (Psychology)
- Trial name
- NCT07109063
- Where
- Iraq
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hameed Adnan Hameed
Cerebral Palsy (CP), Oncology
Acceptability and Tolerance Study of Bolus Tube Feed With Food Blends
This is a prospective acceptability study to evaluate the gastrointestinal tolerance and compliance of a bolus tube feed over a 28 -day period for up to 50 participants.
- Trial name
- Blends (NCT07341464)
- Testing
- Tube feed
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Société des Produits Nestlé (SPN)
Soft Tissue Neoplasms, Bone Neoplasms
Malignant Pediatric Soft Tissue & Bone Tumors of the Extremities: A Retrospective Study
The aim of this study is to identify demographic \& disease characteristics in pediatric oncology patients diagnosed with soft tissue \& bone tumors involving the extremities \& treatment outcomes in these patients.
- Trial name
- NCT02557243
- Where
- Egypt
- Volunteers
- 163 people
- Sponsor
- Assiut University
Deep Vein Thrombosis, Pulmonary Embolism and Thrombosis
Apixaban in Thrombocytopenia
This study is being done to determine the feasibility and safety of using a novel dose adjusted apixaban for the management of participants with cancer-associated venous thromboembolism (blood clot) or and thrombocytopenia (low…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism and Thrombosis, Thrombocytopenia, Recurrent Venous Thromboembolism
- Trial name
- NCT06886516
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rushad Patell
Gastrointestinal Cancers, Frailty at Older Adults
FRAIL and FiND for Chemotherapy Toxicity in GI Cancer
Older adults with gastrointestinal cancer may experience serious side effects during chemotherapy, particularly when they have reduced physical strength, functional limitations, or other health conditions.
- Conditions
- Gastrointestinal Cancers, Frailty at Older Adults, Chemotherapy
- Trial name
- FRAIL-GI (NCT07272538)
- Testing
- No Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Ankara Etlik City Hospital
Median Length of Stay, Readmission Rate
Postoperatory Recovery in Advanced Ovarian Cancer, Fast-Track Protocol vs. Classical Management
The concept of Fast-trak or Enhanced Recovery After Surgery ( ERAS) represents a new approach to the management of patients undergoing major surgery that re-examine traditional practices, replacing them if necessary with the best…
- Conditions
- Median Length of Stay, Readmission Rate, Surgery Related Complications Rate, Cost Per Patient Rate
- Trial name
- PROFAST (NCT02172638)
- Testing
- Fast-Track Protocol, Usual management
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
Breast Cancer
AKY15-HK-301_NEPA Study
Nausea and vomiting (feeling sick to your stomach and throwing up) are two of the most common unpleasant side effects of chemotherapy agents (drugs specifically used to treat cancer) that will be used for cancer treatment.
- Trial name
- NCT03386617
- Testing
- NEPA
- Where
- Hong Kong
- Volunteers
- 55 people
- Sponsor
- Chinese University of Hong Kong
Acute Lymphoblastic Leukemia
Nutritional Status in Children With ALL in Guatemala
This study proposes to investigate the association of nutritional status of a children assessed by body mass index (BMI), triceps skinfold thickness (TSFT), and mid upper arm circumference (MUAC), with body composition, measured…
- Trial name
- NCT03471416
- Where
- Guatemala
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Columbia University
Non-small Cell Lung Cancer
Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance
Research Hypothesis Lung cancer is the leading cause of cancer-related mortality in France and in western countries, accounting for more than 1.8 million new cases and 1.5 million deaths worldwide in 2012.
- Trial name
- PIONeeR (NCT03833440)
- Testing
- Durvalumab (MEDI4736), Monalizumab (IPH2201), Oleclumab (MEDI9447)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ovarian Cancer, Epithelial Ovarian Cancer
A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)
The purpose of this study is to determine which patients with ovarian, fallopian tube, and primary peritoneal cancer will best respond to treatment with rucaparib.
- Conditions
- Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- ARIEL2 (NCT01891344)
- Testing
- Oral rucaparib
- Where
- 75 sites in United States, Australia and 4 more
- Volunteers
- 491 people
- Sponsor
- pharmaand GmbH
Hepatocellular Carcinoma
A Phase 1 Study of MM-141 in Patients With Advanced Solid Tumors
This study is a Phase 1 and pharmacologic open-labeled dose-escalation trial using a "3+3" design, evaluating MM-141 at varying dose levels and frequencies.
- Trial name
- NCT01733004
- Testing
- MM-141
- Where
- 4 sites in United States, France
- Volunteers
- 42 people
- Sponsor
- Merrimack Pharmaceuticals
Hodgkin Lymphoma, Lymphocytic Leukemia
Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies
Background: Allogeneic blood and marrow stem cell transplantation (BMT) plays an important role in the curative treatment of a number of pediatric malignancies.
- Conditions
- Hodgkin Lymphoma, Lymphocytic Leukemia, Mixed Cell Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT00013533
- Testing
- Stem cell transplantation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Myeloid, Chronic-Phase
Treatment Patterns and Key Endpoints Among Patients With Chronic-Phase Chronic Myeloid Leukemia in a Community Oncology Setting
This was a retrospective observational study to examine treatment patterns, molecular testing patterns, treatment response, and clinical outcomes among patients initiating first-line (1L) tyrosine kinase inhibitor (TKI) treatment…
- Trial name
- NCT07374120
- Where
- United States
- Volunteers
- 1,480 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Colo-rectal Cancer
Interventional Study on DEterminants and Factors of Physical ACtivity After Treatments in Oncology
Benefits of physical activity (PA) as supportive care in cancer have been widely demonstrated by the scientific community. However, survivors who have completed chemo-radio-immunotherapy treatments doesn't achieve PA…
- Conditions
- Breast Cancer, Colo-rectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- DEFACTO2 (NCT05354882)
- Testing
- Physical activity program
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Université Sorbonne Paris Nord
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