Clinical trials: Older Adults
Aging
Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training
The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning.
- Trial name
- EXCITE (NCT03957213)
- Testing
- Acute Intermittent Hypoxia, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Florida
Frailty, Mobility Limitation
Promoting Movement in Older Adults in the Community
It is well known that exercise is great medicine, however, for frail older adults who are often homebound and require assistance with personal care, there are gaps in both prescribing this "medicine" and in filling the…
- Trial name
- (ProMO) (NCT04044846)
- Testing
- Physical activity program for homebound older adults faciliated by Personal Support Workers
- Where
- Canada
- Sponsor
- Regional Geriatric Program of Toronto
ADHD
Amphetamine Extended Release Tablets and Driving Performance in Subjects With Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to assess the effect on driving performance of a single dose of amphetamine extended-release tablets (20 mg/tablet) compared with placebo at 45 minutes and 10 hours post-dose in young adults with ADHD.
- Trial name
- NCT04027361
- Testing
- Amphetamine Extended Release (ER) Tablet 20 mg
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Tris Pharma, Inc.
Depression, Alexithymia
Effects of 12-week Exercises on Alexithymia, Depression and Quality of Life in Geriatric Individuals
The aim of this study is to investigate the effects of aerobic and resistance exercises on depression, alexithymia levels and quality of life of elderly individuals.
- Conditions
- Depression, Alexithymia, Quality of Life, Physical Inactivity
- Trial name
- EXQUALITY (NCT05342142)
- Testing
- Aerobic and ResistanceExercise
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Functional Impairment, Frailty
A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings
Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent.
- Trial name
- NCT06404970
- Testing
- Screening intervention, Standard bundle of implementation strategies, Enhanced bundle of implementation strategies
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- VA Office of Research and Development
Adverse Event Following Immunisation
A Study to Evaluate the Safety and Immunogenicity of Oral Polio Vaccine Type 2 in Infants and Children
Sabin 2 will be withdrawn from routine use globally from April 2016 as per the SAGE recommendations at the time of writing this protocol.
- Trial name
- M2-ABMG (NCT02521974)
- Testing
- SABIN monovalent OPV2
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Fidec Corporation
Tuberculosis
Effect of PA-824 and of PA-824 Plus Moxifloxacin on the QTc Interval in Healthy Volunteers
This is a Phase I, single-center, double-blinded, randomized, placebo-controlled, five-period cross-over clinical study of PA-824 to evaluate the effect of PA-824 and of PA-824 plus moxifloxacin on cardiac repolarization (QT/QTc…
- Trial name
- NCT01674218
- Testing
- Moxifloxacin, PA-824
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Pain, Musculoskeletal Pain
Video Intervention for Older Adults With Chronic Pain
Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased quality of life.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Older Adults With Chronic Pain
- Trial name
- NCT07404618
- Testing
- Reclaim Your Day, Health education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Butler Hospital
Acute Pain
A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain
The purpose of the study was to evaluate the efficacy of tapentadol oral solution, based on the total amount of supplemental opioid analgesic used over 12 hours or 24 hours after initiation of investigational medicinal product…
- Trial name
- NCT02081391
- Testing
- Tapentadol oral solution 4 mg/mL, Tapentadol oral solution 20 mg/mL
- Where
- 43 sites in United States, Bulgaria and 8 more
- Volunteers
- 216 people
- Sponsor
- Grünenthal GmbH
Leukemia
Allogeneic CART-19 for Elderly Relapsed/Refractory CD19+ ALL
The purpose of this study is to evaluate the safety and efficiency of allogeneic cluster of differentiation 19 (CD19)-directed chimeric antigen receptor modified T cells (CART-19) infusions in patients with relapsed / refractory…
- Trial name
- NCT02799550
- Testing
- allogeneic CART-19
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
Sarcopenia
Feasibility of a Resistance Exercise and Dietary Protein Intervention in Elderly People in Practice (ProMuscle 65PK)
The purpose of this pilot study is to investigate the feasibility and potential impact of a combined resistance exercise and increased protein intake intervention in (frail) elderly, in a real-life setting.
- Trial name
- NCT02434289
- Testing
- Dietary protein products, Resistance exercise training
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Wageningen University
NAFLD, PCOS
Bicalutamide Therapy in Young Women With NAFLD and PCOS
Nonalcoholic steatohepatitis (NASH), or fat-related liver inflammation and scarring is projected to be the leading cause of cirrhosis in the United States (U.S.) within the next few years.
- Trial name
- NCT05979389
- Testing
- Bicalutamide 50 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Aplastic Anaemia, HSCT
Reduced-dose Conditioning Regimen Containing TBI in HSCT Treating Elderly Patients With Aplastic Anemia
The TBI-containing reduced-dose conditioning regimen was used to treat elderly patients with aplastic anemia who received hematopoietic stem cell transplantation.
- Conditions
- Aplastic Anaemia, HSCT, TBI, Old Age
- Trial name
- NCT06769568
- Testing
- reduced-dose conditioning regimen containing TBI in hematopoietic stem cell transplantation treating elderly patients with aplastic anemia
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Accidental Falls/Prevention and Control
Nursing Home Prevention of Injury in Dementia (NH PRIDE)
The purpose of this study is to develop a consistent approach to prevent falls with injury in nursing home (NH) residents. A centralized Injury Liaison Service (ILS) will be developed and tested in four nursing home facilities…
- Trial name
- NH PRIDE (NCT04242186)
- Testing
- Injury Liaison Service
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Hebrew SeniorLife
Influenza
Safety and Immunogenicity of a Commercially Available Influenza Vaccine (Formulation 2006/2007) When Administered to Subjects 18 Years of Age or Older
The present study aims to evaluate safety and immunogenicity of one dose of a commercially available Surface Antigen, Inactivated Influenza Vaccine, Formulation 2006-2007, in non-elderly adult and elderly subjects.
- Trial name
- NCT00342940
- Testing
- influenza surface antigen inactivated vaccine
- Where
- United Kingdom
- Sponsor
- Novartis
Influenza, Human
Phase 3 Safety and Immunogenicity Study of aQIV in Elderly Adults
This phase 3 study is a randomized, double-blinded, comparator controlled, parallel-group, multicenter study of aQIV versus the US-licensed 2017-2018 adjuvanted trivalent influenza vaccine (aTIV-1, Fluad), and versus an…
- Trial name
- NCT03314662
- Testing
- MF59-adjuvanted Quadrivalent Subunit Inactivated Egg-derived Influenza Vaccine (aQIV), Licensed MF59-adjuvanted Trivalent Subunit Inactivated Egg-derived Influenza Vaccine (aTIV-1), MF59-adjuvanted Trivalent Subunit Inactivated Egg-derived Influenza Vaccine Containing the Alternate B Strain (aTIV-2)
- Where
- 20 sites in United States
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- Seqirus
Diabetes Mellitus, Type 2, Influenza
Information-Based Interventions for Influenza Vaccination Among Older Adults With Diabetes in Yangzhou, China
Influenza can cause serious illness in older adults, particularly those with diabetes. Although influenza vaccination is an important preventive measure, vaccination uptake among older adults in China remains low.
- Trial name
- NCT07901673
- Testing
- Standard Information Intervention, Gain-Framed Information Intervention, Loss-Framed Information Intervention
- Where
- 4 sites in China
- Volunteers
- 759 people
- Sponsor
- Southeast University, China
Cardiovascular Disease, Dementia
Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia
DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults.
- Trial name
- DAN-ZOSTER (NCT07485283)
- Testing
- Recombinant Herpes Zoster Vaccine (Shingrix)
- Where
- 2 sites in Denmark
- Volunteers
- 168,460 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Cancer, Older Adults (65 Years and Older)
Cognition in Older Adults With Cancer Receiving Systemic Anti-Cancer Therapy
The majority of cancer diagnoses occur in adults age 65 years and over. This population is also rapidly expanding. There is a growing need for increased understanding about the potential impact of various newer therapies on…
- Conditions
- Cancer, Older Adults (65 Years and Older), Cognition
- Trial name
- CORreCT (NCT07411105)
- Where
- 2 sites in Ireland
- Volunteers
- 30 people
- Sponsor
- Our Lady's Hospice and Care Services
Dental Prosthesis
Microbiome Effects of Extended Use of MI Paste in Elderly Removable Denture Wearers
The purpose of this study is to determine if MI Paste affects the bacteria and fungus present within the mouth, as well as to determine if MI Paste increases denture comfort and retention.
- Trial name
- NCT06406751
- Testing
- MI Paste
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Iowa
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