Clinical trials: Old Age; Dementia
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer Disease
Sensory Support Care for Elderly Patients Suffering From Alzheimer'S-type Neurodegenerative Disease
The main objective of this study is to evaluate the effect of 3 months of "Snoezelen-type" multi-sensory care sessions on NeuroPsychiatric Inventory Questionnaire (NPI-Q) scores for patients with Alzheimer's-type…
- Trial name
- SensiCare (NCT01819714)
- Testing
- Multi-sensory supportive care
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Neurocognitive Disorders, Dementia
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension.
- Conditions
- Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
- Trial name
- TAHOC (NCT05845736)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Central Hospital, Nancy, France
Physical Therapy
Comparison of Strengthening and Balance Exercises in Early-Stage Dementia
The aim of this study was to examine and compare the effects of balance exercises versus strengthening exercises on gait and cognitive parameters in older adults with early-stage dementia.
- Trial name
- NCT07040007
- Testing
- Strengthening Exercises, Balance Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Zeynep Beyza Kuşva
Alzheimer Disease
Phase 1 Study of OLX-07010 in Healthy Adult and Elderly Participants
This First-in-human (FIH) study will evaluate the safety, tolerability, and pharmacokinetics of the tau self-association inhibitor, OLX-07010 in single ascending doses (SAD) and multiple ascending doses (MAD) in healthy adults…
- Trial name
- NCT05696483
- Testing
- OLX-07010 Active
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Oligomerix, Inc
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Alzheimer Disease, Mild Cognitive Impairment
Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging
The physio-pathology of Alzheimer's disease (AD) remains unknown and there is no cure. Thus, the search for objective markers of preclinical first signs of cognitive impairment, is currently a major public health issue.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia
- Trial name
- NCT01815112
- Testing
- Magnetic resonance imaging, Positron emission tomography
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dementia, Elderly
Effect of Activities and Exercise on Sleep in Elderly Persons With Dementia
The purpose of the study is to determine whether individualized social activities, physical resistance training and walking, and a combination of both are effective in improving nighttime sleep in elders with dementia.
- Conditions
- Dementia, Elderly, Sleep
- Trial name
- NCT00888706
- Testing
- Control Condition, Individualized Social Activities (ISA), Physical Resistance Training and Walking (PRT/walking)
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- National Institute of Nursing Research (NINR)
Periodontitis, Alzheimer Disease
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority.
- Trial name
- ORAMICAL (NCT05077618)
- Testing
- sampling of dental plaque and blood sample during the treatment
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy
Activation-Socialization Intervention Program for Seniors
Objective No. 1: Verify the short-term effectiveness of the Activation-Socialization Intervention Program on the experiences (emotionality, anxiety) and behavior (agitated behavior) of seniors in the experimental and control…
- Trial name
- NCT07498179
- Testing
- Activation and Socialization Intervention Program
- Where
- Slovakia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Diana Ďuricová
Frailty, Dementia
HEalthy Aging Team Supported Home-care Services (HEAT-YASAM)
Depending on the YASAM project which was established to home-visit evaluate community-dwelling older adults (80 years of age and over), we aimed to determine the prevalence (prevalence) of geriatric syndromes (dependence…
- Conditions
- Frailty, Dementia, Depression, Malnutrition
- Trial name
- HEAT-YASAM (NCT05993572)
- Testing
- Comprehensive Geriatric Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Alzheimer's Disease
Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age
The study determined the safety of CNP520 in healthy elderly over 3 months. Data relevant for Pharmacokinetic/Pharmacodynamic modeling were obtained in order to define the target dose in subsequent efficacy studies.
- Trial name
- NCT02576639
- Testing
- CNP520
- Where
- 11 sites in United States, Belgium and 3 more
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Mild Cognitive Impairment, Probable Alzheimer's Disease
Dietary Treatments for Cognitive Impairment in Older Adults
This trial seeks to establish the feasibility of implementing a ketogenic, modified Atkins diet (MAD) to older adults with mild cognitive impairment (MCI) or early Alzheimer's disease (AD) living in the community.
- Trial name
- NCT02521818
- Testing
- Modified Atkins Diet, NIA Diet for Seniors
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Alzheimer Disease
Locus-coeruleus Function in Normal Elderly and AD Risk
Growing evidence suggests that Alzheimer's disease (AD) pathological changes begin decades before clinical symptoms and tau abnormalities in the locus coeruleus (LC) can be observed since midlife.
- Trial name
- LEAD (NCT04403165)
- Testing
- Nocturnal polysomnography (NPSG), Lumbar Puncture (LP), PET-MR measurement with a norepinephrine transporter (NET)-selective radiotracer (S,S)-[11C]Omethylreboxetine ([11C]MRB)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alzheimer Disease, Healthy
Study Evaluating Safety of GSI 136 in Young and Elderly Japanese Males
This is a first-in-human study of GSI-136, a gamma-secretase inhibitor being developed for the treatment of Alzheimer disease. This study will take place in Japan only and will provide an initial assessment of the safety…
- Trial name
- NCT00719394
- Testing
- GSI 136
- Where
- Japan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Dementia
Prognosis of Depression in the Elderly (PRODE). A Multicentre, Longitudinal Study of Elderly Depressed Patients.
PRODE is a Norwegian multicentre study investigating the prognosis of depression in the elderly. The study has included 169 patients who will be followed with assessments after one and three years.
- Trial name
- PRODE (NCT01952366)
- Where
- Norway
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Sykehuset Innlandet HF
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer's Disease
Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects
This is a Phase 1, Randomized, Placebo-Controlled, Double-Blind, Study of Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects.
- Trial name
- NCT01467726
- Testing
- Velusetrag
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alfasigma S.p.A.
Mild Cognitive Impairment, Dementia Alzheimers
Protecting Alzheimer Caregivers Using Technology Through Staying Sharp
PROACTS is a Phase I/II study to assess the efficacy of AARP Staying Sharp online health program, focusing on the health of non-professional home-based caregivers of persons with Alzheimer's disease and related dementias (ADRD).
- Conditions
- Mild Cognitive Impairment, Dementia Alzheimers, Old Age; Dementia, Caregiver Burden
- Trial name
- PROACTS (NCT05260515)
- Testing
- Staying Sharp intervention
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University