Clinical trials: Occlusion
Pain
Paracervical Block for Pain Associated With Laminaria Insertion
To assess if paracervical block is effective at reducing discomfort during placement of intracervical laminaria for pre-operative cervical preparation.
- Trial name
- NCT02454296
- Testing
- Paracervical Block with lidocaine
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Sickle Cell Anemia Crisis
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
- Trial name
- NCT03541980
- Testing
- Acetaminophen, Normal saline
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Newark Beth Israel Medical Center
Thoracic Surgical Procedures
Erector Spinae Plane vs. Paravertebral Nerve Block for Thoracic Surgery
Continuous paravertebral analgesia and erector spinae plane blockade (ESP) are accepted techniques at University of Pittsburgh Medical Center (UPMC) for the management of thoracic pain following surgery and trauma.
- Trial name
- NCT03758261
- Testing
- Paravertebral nerve block, Erector Spinae nerve block
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Charles Luke
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Dentin Sensitivity
A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.
This study will investigate the longitudinal efficacy of two experimental oral rinses, one containing 1.5% weight/weight (w/w) dipotassium oxalate monohydride (KOX) /0 Parts per Million (ppm fluoride) and the other 2.0% w/w KOX…
- Trial name
- NCT02753075
- Testing
- Experimental Oral Rinse 1, Experimental Oral Rinse 2, Fluoride toothpaste
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Disorder, Coronary Artery Disease
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
This clinical trial develops and tests a culturally-appropriate educational program (Indigenous SIPin) for reducing sugar-sweetened beverage consumption in men affiliated with Native American athletics communities.
- Conditions
- Cardiovascular Disorder, Coronary Artery Disease, Diabetes Mellitus, Obesity-Related Malignant Neoplasm
- Trial name
- NCT06029517
- Testing
- Education Intervention, Observation of Indigenous SIPin Interventon, Discussion
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Visual Acuity
Evaluation of Toric Soft Contact Lenses Containing a Chromophore to Block High-Energy Visible Light
This will be a 4-visit, randomized, controlled, single-masked, bilateral wear, dispensing, 2-treament, 2-sequence, 3-period crossover study to evalulate overall vision and comfort..
- Trial name
- NCT05344560
- Testing
- soft contact lens in senofilcon A (C3) with HEVL-blocking chromophore, ACUVUE OASYS 1-Day for Astigmatism
- Where
- 10 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Healthy
Safety, Tolerability, Pharmacokinetic Characteristics of hzVSF-v13 in Healthy Male Volunteers
To investigate the safety/tolerability and pharmacokinetic characteristics after single intravenous (IV) administration of hzVSF-v13 (humanized Virus Suppressing Factor-variant 13) in healthy male volunteers
- Trial name
- NCT03653208
- Testing
- hzVSF-v13
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- ImmuneMed, Inc.
Pain, Patient Satisfaction
Effect of VR on Pain and Patient Satisfaction in Adults Receiving GNRFA
The study team aims to investigate whether implementing virtual reality therapy (VRT) during Genicular nerve radiofrequency ablation (GNRFA) procedure will provide better alleviation of procedural pain and augmented satisfaction…
- Trial name
- NCT05468398
- Testing
- Soothe VR
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Onset and Duration of a Digital Nerve Block
Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers
The duration of the autonomic (sympathetic) block will last longer than the sensory block. The duration of the increased perfusion index will last longer than either the sympathetic or sensory block.
- Trial name
- NCT01508832
- Testing
- Lidocaine Digital Nerve Block, Bupivacaine Digital Block
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Regional Anesthesia, Sciatic Nerve Block
Comparing Through-the-Needle With Suture-Method Catheter Designs for Popliteal Nerve Blocks
Following painful surgical procedures, postoperative analgesia is often provided with a single-injection peripheral nerve block.
- Trial name
- NCT03442036
- Testing
- Suture-Method Technique, Through-the-Needle Technique
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dentin Sensitivity
Study to Evaluate the Effectiveness of Test Dentifrice in the Relief of Dentinal Hypersensitivity
The purpose of this study is to compare the clinical efficacy of test fluoride dentifrice in reducing Dentin Hypersensitivity (DH) with that of a standard fluoride dentifrice, as measured by evaporative air sensitivity after 12…
- Trial name
- NCT07317128
- Testing
- Test Dentifrice, Colgate Sensitive ProRelief, Colgate Triple Protection
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Pain
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw.
- Trial name
- NCT01574807
- Testing
- mepivacaine + lidocaine followed by lidocaine +lidocaine, lidocaine + lidocaine followed by mepivacaine + lidocaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Postoperative Pain
Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management
To evaluate the efficacy of bilateral continuous erector spinae blocks (BESB) for postoperative analgesia in children and adolescents undergoing cardiac surgical procedures via sternotomy in the Early Recovery After Surgery…
- Trial name
- NCT04567407
- Testing
- Bilateral erector spinae blocks using ropivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Atherosclerosis
Inflammation and Vascular Function in Atherosclerosis
The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.
- Trial name
- NCT00760019
- Testing
- salsalate
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post-operative Pain
Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial
This study investigates the use of post-operative on-Q pain catheters for tissue expander based breast reconstruction, versus conventional ultrasound-guided blocks placed pre-operatively.
- Trial name
- NCT03201809
- Testing
- On-Q, Ultrasound guided pectoral nerve block
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Dentin Sensitivity
The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)
This single center study will investigate the efficacy of an experimental stannous fluoride containing dentifrice in relieving DH compared with a standard fluoride dentifrice after short term use.
- Trial name
- NCT02924350
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- United Kingdom
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Myocardial Infarction
Subclinical Cardiovascular Disease in Psoriatic Disease
This study will look at how chronic inflammation seen in psoriatic disease translates into the increased atherosclerotic and thrombotic risk and how treatment reduces this CVD risk.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Atherosclerotic Cardiovascular Disease, Thrombotic Vascular Disease
- Trial name
- NCT03228017
- Testing
- Aspirin and/or Atorvastatin
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health