Clinical trials: Obturation
Respiratory Failure, Weaning Failure
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure
Mechanical ventilation is essential in the management of patients in Intensive Care. The approach to patients with prolonged weaning is challenging.In this context, it is vital to implement "diaphragmatic protection" strategies…
- Trial name
- PTPPocc (NCT06040138)
- Testing
- End expiratory occlusion maneuver
- Where
- 4 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Intrasaccular neCk Occlusion deVice Treatment of Intracranial Aneurysm in Acute Subarachnoid hemorRhAGE
Rationale: Intrasaccular neck occlusion devices have been used for unruptured aneurysm without safety concerns and good occlusion rates.
- Trial name
- COVERAGE (NCT05171465)
- Testing
- Neqstent or Contour
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Retinal Vein Occlusions
Anatomic Outcomes Following Ozurdex Injections
Ozurdex(TM) has recently been FDA approved for use in macular edema secondary to retinal vein occlusion. It remains unclear how quickly the drug works and for how long as the initial studies did not have frequent anatomic…
- Trial name
- NCT01282411
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Barnes Retina Institute
Atrial Fibrillation, Cardioembolic Stroke
Long-term Results of Percutaneous Left Atrial Closure at Brest University Hospital (CLAPOT)
Atrial Fibrillation represents an important risk of cardioembolic stroke. In more than 90% of cases, thrombus originate in the left atrial appendage.
- Conditions
- Atrial Fibrillation, Cardioembolic Stroke, Left Atrial Appendage Thrombosis, Anticoagulant-induced Bleeding
- Trial name
- CLAPOT (NCT06232278)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Brest
Stroke, Ischemic Stroke
EndoVascular Treatment With Stent-retriever and/or Thromboaspiration vs. Best Medical Therapy in Acute Ischemic Stroke
Prospective, multi-center, randomized, controlled, open, blinded-endpoint trial with a sequential design. The randomization employs a 1:1 ratio of mechanical thrombectomy with stentriever and/or Thromboaspiration versus medical…
- Trial name
- RESILIENT (NCT02216643)
- Testing
- Thrombectomy, Stentriever Solitaire FR® or Penumbra System®
- Where
- 15 sites in Brazil
- Volunteers
- 221 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Ischemic Stroke, Vessel Occlusion
REal-World Analyses of Stroke - Thrombus Occlusion REtrieval
To collect real-world evidence allowing assessment of functional, imaging, and safety outcomes of MicroVention market-released acute ischemic stroke devices when used at the direction of the treating physician.
- Conditions
- Acute Ischemic Stroke, Vessel Occlusion, Stroke, Ischemic
- Trial name
- "RESTORE" (NCT04451525)
- Testing
- MicroVention Mechanical Thrombectomy Devices as first-line treatment
- Where
- 37 sites in United States
- Volunteers
- 710 people
- Sponsor
- Microvention-Terumo, Inc.
Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease
EXCEL Clinical Trial
To establish the safety and efficacy of the commercially approved XIENCE Family Stent System (inclusive of XIENCE PRIME, XIENCE V, XIENCE Xpedition and XIENCE PRO [for use outside the United States [OUS] only]) in subjects with…
- Conditions
- Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease, Stent Thrombosis, Vascular Disease
- Trial name
- EXCEL (NCT01205776)
- Testing
- Percutaneous Coronary Intervention, CABG
- Where
- United States
- Volunteers
- 1,905 people
- Sponsor
- Abbott Medical Devices
Pneumothorax
Evaluation of the Feasibility, Safety, and Efficacy of Single-use Endobronchial Silicon Spigots for the Treatment of Refractory Pneumothorax
Study Objective: To evaluate the feasibility and safety of the disposable endobronchial silicon spigots for treating refractory pneumothorax and to preliminarily assess its efficacy, providing domestic experience for the…
- Trial name
- NCT06515015
- Testing
- Endobronchial Silicon Spigots
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hangzhou Broncus Medical Co., Ltd.
Acute ST-segment Elevation Myocardial Infarction, Radial Artery Occlusion
Distal Transradial Access for Primary Percutaneous Coronary Intervention in STEMI Patients
The transradial access (TRA) is currently the preferred approach for percutaneous coronary intervention (PCI). However, in patients with ACUTE ST-segment elevation myocardial infarction (STEMI) after emergency PCI, the high…
- Conditions
- Acute ST-segment Elevation Myocardial Infarction, Radial Artery Occlusion, Distal Radial Artery Approach
- Trial name
- RESERVE (NCT04861389)
- Testing
- Arterial access
- Where
- China
- Volunteers
- 414 people
- Sponsor
- Shenzhen People's Hospital
Shock
Predicting Fluid Responsiveness During Shock in Newborns and Infants by End-expiratory Occlusion Test
To date, the end-expiratory occlusion test in infants or children has never been evaluated as a marker of preload dependence. It therefore appears clinically relevant to evaluate this new indicator to predict fluid responsiveness…
- Trial name
- EVEOC (NCT04932590)
- Testing
- End-expiratory occlusion test
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke
Total Posterior-circulation Infarct Volume in Basilar Artery Stroke
Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial.
- Trial name
- TPCIV-ABAO (NCT04650022)
- Testing
- Mechanical thrombectomy
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Montpellier
Arteriosclerosis
The Clinical Research of Low Intensity Continuous Ultrasonic on Lower Limb Arteriosclerosis Occlusion（ASO） Syndrome
In the present study, by evaluating the efficacy and safety of low intensity ultrasonic on ASO, to explore the noninvasive auxiliary treatment of ASO.
- Trial name
- NCT02866656
- Testing
- Conventional conservative treatment, therapeutic ultrasound
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Tooth Discoloration Following Root Canal Treatment
TOOTH DİSCOLORATİON AFTER ROOT CANAL TREATMENT WİTH AH PLUS AND BİOROOT RCS
he purpose of this clinical study is to compare tooth color changes after root canal treatment using two different root canal sealers, AH Plus and BioRoot RCS, in upper front teeth.
- Trial name
- NCT07849296
- Testing
- AH Plus Root Canal Sealer, BioRoot RCS Root Canal Sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Susac Syndrome
Physiotherapy Approach for Susac Syndrome
Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss.
- Trial name
- NCT06349603
- Where
- Bosnia and Herzegovina
- Volunteers
- 1 people
- Sponsor
- Rehabilitation Centre Zivot
Coronary Arterial Disease (CAD), Radial Artery Spasm
Impact of Preprocedural Stress Ball Use on Radial Artery Outcomes in Elective Coronary Angiography
This randomized, double-blind, controlled trial aims to evaluate the effect of preprocedural hand exercise using a stress ball on the incidence of radial artery spasm and other vascular complications in patients undergoing…
- Conditions
- Coronary Arterial Disease (CAD), Radial Artery Spasm, Radial Artery Occlusion, Transradial Angiogram
- Trial name
- SPARROW (NCT07087522)
- Testing
- Stress Ball Use
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sakarya University
Coronary Artery Disease
XIENCE V® Everolimus Eluting Coronary Stent System USA Post-Approval Study (XIENCE V® USA-Phase 1)
XIENCE V USA is a prospective, multi-center, multi-cohort post-approval study. The objectives of this study are To evaluate XIENCE V EECSS continued safety and effectiveness during commercial use in real world settings, and To…
- Trial name
- XVU-Phase 1 (NCT00676520)
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent
- Where
- United States
- Volunteers
- 8,053 people
- Sponsor
- Abbott Medical Devices
Coronary Disease, Coronary Artery Disease
PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions
PROSPECT is a multi-center prospective registry of Acute Coronary Syndromes (ACS) patients with single or double vessel coronary artery disease.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- NCT00180466
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 697 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
REgistry on Real-Life EXperience With Left Atrial Appendage Occlusion
The objective of this observational non-randomized multicenter study is to compile real-world clinical characteristics and outcomes data for patients treated with LAA (left atrial appendage) closure systems in a daily clinical…
- Trial name
- RELEXAO (NCT03279406)
- Testing
- Percutaneous Left Atrial Appendage Occlusion
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours
Coronary Artery Disease, Cardiovascular Diseases
Comparison of the Diagnostic Performance and Costs of FFRB Vs. Standard Care in Suspected Coronary Artery Disease.
Chest pain due to coronary artery disease (CAD) is a main driver of healthcare costs. Fractional flow reserve (FFR) measurement during invasive coronary angiography (ICA) is the gold standard to discriminate ischemia.
- Conditions
- Coronary Artery Disease, Cardiovascular Diseases, Cardiovascular; Stenosis, Coronary Occlusion
- Trial name
- ECONOMY (NCT06681584)
- Testing
- CTCA
- Where
- 3 sites in Singapore
- Volunteers
- 340 people
- Sponsor
- National Heart Centre Singapore
Healthy Subjects, Diabetic Retinopathy
Comparison of Retinal Oxygenation and Retinal Vessel Diameters in Healthy Subjects and Patients With Diabetic Retinopathy or Retinal Vein Occlusion Between DVA and Oxymap
To date two different instruments are commercially available to measure retinal oxygen saturation and retinal vessel diameters: Dynamic Vessel Analyzer (DVA) and Oxymap.
- Conditions
- Healthy Subjects, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- DVA-Oxymap (NCT02521116)
- Testing
- Dynamic Vessel Analyzer, Oxymap T1
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna