Clinical trials: Obstructive Sleep Apnea of Adult
Obstructive Sleep Apnea of Adult, Acute Coronary Syndrome
OSA-ACS Project: Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease.
- Trial name
- NCT03362385
- Testing
- Patients with OSA based on sleep study, Patients without OSA based on sleep study
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- Beijing Anzhen Hospital
Sleep Apnea, Obstructive
Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- DESOSA (NCT02428478)
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea of Adult
Vascular Endothelial Dysfunction in Sleep Apnea
This double-blind placebo-controlled parallel group randomized study design will be used to test whether 4 weeks of atorvastatin 10 mg daily reduces levels of inflammatory markers in OSA patients treated with CPAP (standard of…
- Trial name
- NCT05289063
- Testing
- Atorvastatin 10mg, Continuous Positive Airway Pressure Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Apnea, Sleep Disorders
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)
This study is being done to learn about the safety and effects of a study medicine called berobenatide (bear-oh-BEN-uh-tide). The study will see if berobenatide can help adults with breathing problems during sleep (obstructive…
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Trial name
- NCT07823608
- Testing
- Berobenatide
- Where
- 6 sites in United States
- Volunteers
- 258 people
- Sponsor
- Pfizer
Obstructive Sleep Apnea of Adult
Change in Tongue Strength and Fatigue After Upper Airway Stimulation Therapy
Upper airway stimulation (UAS) is an effective surgical alternative for patients with obstructive sleep apnea (OSA) who fail continuous positive airway pressure (CPAP) therapy.
- Trial name
- NCT03980158
- Where
- Germany
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea of Adult
Efficacy of Oropharyngeal Exercises for Patients With Obstructive Sleep Apnea Using Mandibular Advancement Device
Combined treatment with MAD and OE for adult patients with obstructive sleep apnea can significantly (i) improve muscle strength and endurance; (ii) reduce the severity of sleep apnea.
- Trial name
- NCT05717959
- Testing
- Oropharyngeal Exercises
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Obstructive Sleep Apnea of Adult
Pilot Study of the MultiSense Patch to Record Cardiopulmonary Data During Sleep and Wake Cycles
The investigators are proposing to use a wearable device, MultiSenseTM, developed by Rhythm Diagnostic Systems, Inc. which has many sensors inside in a "Band-Aid" like strip in order to see if it can help diagnose capabilities in…
- Trial name
- NCT02222103
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Obstructive Sleep Apnea of Adult, Heart Valve Diseases
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement
Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease.
- Trial name
- NCT03839654
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing Medical University
Obstructive Sleep Apnea of Adult, Positive Airway Pressure
Effect of Smart Watch and App on PAP Adherence in OSA (Watch-OSA)
Continuous positive airway pressure (CPAP) is highly effective in treating obstructive sleep apnea (OSA). However, this treatment modality relies heavily on patient adherence, and poor adherence to the treatment limits its…
- Conditions
- Obstructive Sleep Apnea of Adult, Positive Airway Pressure, Adherence, Treatment, Smart Watch
- Trial name
- NCT05530265
- Testing
- the smart watch and Samsung Health app
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital
Excessive Daytime Sleepiness, Narcolepsy
Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
The purpose of this study is to assess patient reported outcomes with armodafinil treatment in terms of improvement in sleepiness, satisfaction with treatment, impact on ability to engage in life activities (ie, daily or work and…
- Conditions
- Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
- Trial name
- NCT00228566
- Testing
- Armodafinil
- Where
- 43 sites in United States
- Volunteers
- 247 people
- Sponsor
- Cephalon
Sleep Apnea, Obstructive
A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea
The purpose of this study is to evaluate the effect of multiple doses of seltorexant compared with placebo on respiration during sleep in adult participants with mild to moderate obstructive sleep apnea.
- Trial name
- NCT03796026
- Testing
- Seltorexant 40 mg
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Janssen Research & Development, LLC
Obstructive Sleep Apnea of Adult, Pregnancy Related
Mandibular Advancement Device (MAD) in Pregnant Women With Obstructive Sleep Apnea (OSA)
We propose a single-arm trial to test the patient uptake and preliminary efficacy of MAD in a sample of 10 pregnant women with mild-to-moderate OSA.
- Trial name
- OBMAD (NCT06256640)
- Testing
- Mandibular advancement Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Obstructive Sleep Apnea
The Influences of Intervention With Home-based Recovery Activity in Obstructive Sleep Apnea Syndrome
Background: OSAS is a type of sleep disorder characterized by intermittent, partial or complete upper airway (UA) collapse, seriously impacting sleep apnea and respiratory insufficiency.
- Trial name
- OSAS (NCT02278094)
- Testing
- Tongue Muscle Trainer (TMT), Threshold Inspiratory Muscle Trainer (TIMT), Walking Exercise
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Cheng-Kung University Hospital
Obstructive Sleep Apnea
BilatEral Hypoglossal Nerve StimulaTion for TreatmEnt of ObstRuctive SLEEP Apnoea With and Without Complete Concentric Collapse
The objective of this study is to explore the safety and performance of the Genio™ system in adult obstructive sleep apnoea (OSA) patients with and without complete concentric collapse of the soft palate over a period of 4.5…
- Trial name
- BETTER SLEEP (NCT03763682)
- Testing
- Genio(TM) bilateral hypoglossal nerve stimulation system
- Where
- 4 sites in Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nyxoah S.A.
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Obstructive Sleep Apnea of Adult
Investigation of Predictive Indices to Objectively Guide Choice of CPAP Interface
Obstructive sleep apnea (OSA) is a prevalent disease, and one that is associated with significant negative impact on long-term survival.
- Trial name
- NCT03063567
- Testing
- CPAP interfaces
- Volunteers
- 100 people
- Sponsor
- Singapore General Hospital
Obstructive Sleep Apnea, Sleep Apnea Syndromes
Real-World Performance and Safety of Apneal Dx for Sleep Apnea Screening
Sleep apnea-hypopnea syndrome (SAHS) is a frequent and largely under-diagnosed sleep-related breathing disorder. Adult prevalence is estimated between 9% and 38%. Untreated SAHS increases cardiometabolic and neurocognitive risk.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive
- Trial name
- APNEAL-PMCF (NCT07809633)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Mitral
Obstructive Sleep Apnea of Adult, Obesity
Cost-effectiveness Study of a Lifestyle Change Program for the Treatment of OSA and Obesity: Hospital-Primary Care.
Obesity is the main risk factor for Obstructive Sleep Apnea (OSA). Nasal CPAP is the standard treatment for OSA, but since weight-loss programs are not usually offered to OSA patients, the root causes of their illness and its…
- Conditions
- Obstructive Sleep Apnea of Adult, Obesity, Lifestyle, Weight Loss
- Trial name
- SPP-1 (NCT04296721)
- Testing
- Intensive weigh-loss program, Standard Dietary recommendations
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge
Obstructive Sleep Apnea Risk Management, Postoperative Complications
OSA Risk Level in Dental Patients and Correlation With Complications After General Anesthesia
Obstructive sleep apnea (OSA) is a sleep-related respiratory dysfunction. The prevalence of OSA is increasing with the increasing rates of obesity and elderly population worldwide.
- Conditions
- Obstructive Sleep Apnea Risk Management, Postoperative Complications, Dental Caries Under General Anesthesia, Obstructive Sleep Apnea of Adult
- Trial name
- NCT06430957
- Testing
- The STOP-BANG questionnaire for determining OSA risk level., ASA recommended criteria for determining OSA risk level., Record of postoperative complications
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Kırıkkale University
Obstructive Sleep Apnea of Adult
Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea
This is a prospective, multicenter, non-randomized single-arm safety and performance study to collect data to evaluate the safety of the Cryosa procedure to treat obstructive sleep apnea (OSA) in patients with moderate to severe…
- Trial name
- ARCTIC-3 (NCT06008626)
- Testing
- Cryosa Procedure
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cryosa, Inc.