Clinical trials: Obstructive Jaundice
Cholangitis Acute, Biliary Tract Diseases
Antimicrobial Resistance in Acute Cholangitis
This study prospectively explores antimicrobial resistance in patients with acute cholangitis undergoing ERCP procedures. By analyzing patient profiles, microbial cultures, and treatment outcomes, the current study seeks to…
- Conditions
- Cholangitis Acute, Biliary Tract Diseases, Jaundice; Malignant, Jaundice, Obstructive
- Trial name
- ARISE (NCT06197984)
- Testing
- ERCP
- Where
- Romania
- Volunteers
- 1,435 people
- Sponsor
- Emergency County Hospital Pius Brinzeu; Timisoara, Romania
Bile Duct Neoplasms, Jaundice, Obstructive
A Single-center, Prospective Cohort Study on the Differentiation of Benign and Malignant Bile Duct Stenosis Based on Bile and Peripheral Blood cfDNA Methylation Profiles
The goal of this observational study is to detect the methylation characteristics of cfDNA in the bile and plasma of patients with bile duct stricture.
- Conditions
- Bile Duct Neoplasms, Jaundice, Obstructive, Bile Duct Diseases
- Trial name
- NCT06115655
- Testing
- cfDNA methylation detection
- Where
- China
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Obstructive Jaundice, Cholangitis
Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
Primary Objective: To document state-of- the-art multi-modality management of occluded biliary SEMS aiming to minimize number of reinterventions while providing symptom relief without procedure-related serious adverse events.
- Trial name
- NCT03133026
- Testing
- Single operator cholangioscopy, Endoscopic biliary RFA
- Where
- India
- Volunteers
- 4 people
- Sponsor
- Asian Institute of Gastroenterology, India
Obstructive Jaundice
Outcome of Carbon Dioxide Versus Air Insufflations During Endoscopic Retrograde Cholangiopancreatography (ERCP)
To assess the safety and efficacy of CO2 insufflations during ERCP 1. Primary objective: To assess the patient's symptoms, abdominal pain and abdominal distension post procedure (ERCP) in the study group. 2.
- Trial name
- NCT01321203
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Obstructive Jaundice, Pancreatic Head Cancer
Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice
Pancreaticoduodenectomy (PD) is a complex surgical procedure commonly performed for tumors of the pancreatic head and periampullary region.
- Conditions
- Obstructive Jaundice, Pancreatic Head Cancer, Periampullary Neoplasms, Biliary Tract Neoplasms
- Trial name
- NCT07532759
- Testing
- PTCD Catheter Removal, PTCD Catheter Retention
- Volunteers
- 100 people
- Sponsor
- Xu'an Wang
Jaundice, Obstructive
Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography: Precut Versus Conventional Cannulation
Endoscopic sphincterotomy is now an established method for removal of common bile duct calculi and treatment of papillary stenosis, the sump syndrome and certain cases of ampullary carcinoma.
- Trial name
- ERCP (NCT02477228)
- Testing
- conventional ERCP, Precut ERCP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Obstructive Jaundice, Pancreatic Cancer
Endoscopic Ultrasound-guided Biliary Drainage for Malignant Biliary Obstruction After Failed ERCP
In this study the investigators retrospectively report outcomes of direct transluminal EUS-BD in a series of patients with malignant biliary obstruction after failed ERCP as the experience of a single Italian center
- Trial name
- (EUS-BD) (NCT03510754)
- Testing
- Eus guided biliary drainage
- Volunteers
- 36 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Obstructive Jaundice, ERCP
Determinants of Technical Success and Safety in Therapeutic ERCP for Obstructive Jaundice
compare the impact of type of anesthesia on ERCP including technical success, rate of complications, peri procedural safety, patient and endoscopist satisfaction in adult patients with obstructive jaundice
- Conditions
- Obstructive Jaundice, ERCP, Anesthesia Complication, Anesthesia Effectiveness
- Trial name
- ERCP (NCT07563569)
- Testing
- ERCP
- Volunteers
- 100 people
- Sponsor
- Sohag University
Calcular Obstructive Jaundice, Gall Bladder Disease
One Session Vs Staged Management of Calcular Obstructive Jaundice
to compare the outcomes between doing ERCP and laparoscopic cholecystectomy in one session Vs staged management
- Trial name
- NCT05979233
- Testing
- staged managment, one session ERCP then LC, one session LC then ERCP
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Minia University
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07051980
- Testing
- Supraglottic Oxygen Delivery via an Endotracheal Tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Patients With Obstructive Jaundice
Human Kidney Histopathology in Obstructive Jaundice
Introduction: Cholemia and bacterial translocation with portal endotoxemia are integral in the pathogenesis of obstructive jaundice (OJ).
- Trial name
- NCT01090193
- Testing
- Whipple operation,Hepaticojejunostomy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Turkish Ministry of Health Izmir Teaching Hospital
Obstructive Jaundice, Bilio-pancreatic Tumor
Endoscopic Ultrasound Evaluation of the Common Bile Duct in Patients With Obstructive Jaundice Due to Bilio-pancreatic Malignancies (ECCO Trial)
To assess the size of the common bile duct in a large cohort of patients with jaundice following a malignant tumor of the head of the pancreas or the distal bile duct receiving a diagnostic EA for biopsy and / or for evaluation…
- Trial name
- ECCO (NCT05155475)
- Testing
- Ultrasound endoscopy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Obstructive Jaundice
Diagnostic Accuracy of Magnetic Resonance Cholangiopancreatography in Patients With Obstructive Jaundice
Evaluate the diagnostic accuracy of Magnetic Resonance Cholangiopancreatography (MRCP) compared with Ultrasound and Computed Tomography (CT) in patients with obstructive jaundice taking findings of ERCP/ PTC and histopathology as…
- Trial name
- NCT06754397
- Testing
- Magnetic Resonance Cholangiopancreatography
- Volunteers
- 50 people
- Sponsor
- Sohag University
Calcular Obstructive Jaundice
Primary Precutting Versus Conventional Over-the-Wire Sphinchterotomy For Managment Of Large Common Bile Duct Stones
During the last decades, endoscopic retrograde cholangiopancreatography (ERCP) has become the standard of care for the treatment of many pancreaticobiliary diseases [Canena et al., 2014].
- Trial name
- NCT06106724
- Testing
- sphincterotomy, precutting of the papilla by knife needle
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Biliary Stricture, Biliary Tract Diseases
Percutaneous Biodegradable Biliary Stents for the Treatment of Benign Biliary Strictures.
To assess safety and effectiveness in the long term of percutaneous insertion of Biodegradable (BD) Biliary Stents for the treatment of benign biliary strictures, in a single center experience.
- Conditions
- Biliary Stricture, Biliary Tract Diseases, Bile Duct Stricture, Bile Duct Injury
- Trial name
- NCT05556668
- Testing
- Percutaneous placement of biodegradable biliary stents
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Corporacion Parc Tauli
Calcular Obstructive Jaundice
*Effect of Prophylactic CBD Stenting Versus Non Stenting on Recurrence of CBD Stones in Patients Awaiting Cholecystectomy*
Primary objective: Compare recurrence rates of CBD stones in stented versus non-stented patients. Secondary objectives: Identify predictors of stone recurrence. Assess the incidence and risk factors for post-ERCP complications.
- Trial name
- NCT07084493
- Testing
- CBD stent either a 7-Fr and 7 cm or a 10-Fr and 7-cm OR double-pigtail stent, biliary stent
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Assiut University
Postoperative Complications
Preoperative Biliary Drainage for the Lower Malignant Obstructive Jaundice
Patients with the lower malignant obstructive jaundice planned to do the pancreaticoduodenectomy, receiving preoperative biliary drainage or early surgery (without preoperative biliary drainage), both groups has the similar…
- Trial name
- NCT01744938
- Testing
- preoperative biliary drainage
- Volunteers
- 136 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Jaundice; Malignant
Remaxol® in Malignant Mechanical Jaundice
The trial intends to study the safety and efficacy of Remaxol® (succinate + methionine + inosine + nicotinamide; POLYSAN Ltd., Russia),solution for infusion for the reduction of hyperbilirubinemia in patients with obstructive…
- Trial name
- NCT03416062
- Testing
- Remaxol®, Ringer's Solution
- Where
- 18 sites in Russia
- Volunteers
- 240 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Hepatocellular Carcinoma, Obstructive Jaundice
Safety and Efficacy of Photodynamic Therapy for Bile Duct Invasion of Hepatocellular Carcinoma
The prognosis of patients with obstructive jaundice caused by hepatocellular carcinoma (HCC) is dismal even after biliary drainage; due to malfunction of the biliary drainage tube caused by hemobilia and/or tumor emboli.
- Trial name
- NCT01506115
- Testing
- Photofrin
- Where
- South Korea
- Volunteers
- 11 people
- Sponsor
- Samsung Medical Center
Malignant Obstructive Jaundice
Flipped-Discharge Education for PTCD-Managed Malignant Obstructive Jaundice
This single-center randomized controlled trial evaluated whether a structured flipped-discharge education model improves discharge readiness and short-term outcomes compared with routine discharge education in adults with…
- Trial name
- NCT07525804
- Testing
- Flipped-Discharge Education Model, Routine Discharge Education
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First People's Hospital of Foshan