Clinical trials: Obsessive Compulsive Disorders
Obsessive-Compulsive Disorder
A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder
This study is being done to learn whether administration of intranasal (inhaled through the nose) ketamine reduces symptoms of obsessive-compulsive disorder (OCD). Ketamine has been approved by the U.S.
- Trial name
- NCT02234011
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Trichotillomania (Hair-Pulling Disorder), Dermatillomania
Memantine in Body Focused Repetitive Behaviors
This study is 8 weeks long and involves subjects taking memantine or placebo. If they are randomly assigned to the memantine arm and are eligible to participate in the study, they will begin by taking 10mg once daily of memantine…
- Trial name
- NCT04792645
- Testing
- Memantine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Cognitive Behavioral Therapy, Autism Spectrum Disorder
Stepped-Care Cognitive-Behavioral Treatment for Youth With ASD and Anxiety
This study implements a parent-led, flexible, individually-tailored cognitive-behavioral intervention for children with ASD and anxiety.
- Conditions
- Cognitive Behavioral Therapy, Autism Spectrum Disorder, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- NCT03720795
- Testing
- Stepped Care CBT
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Baylor College of Medicine
Hoarding Disorder
Critical Time Intervention for Individuals With Hoarding Disorder
The purpose of this study is to investigate whether a well-established case management model called Critical Time Intervention (CTI) can help individuals with hoarding disorder who are concerned about the risk of eviction.
- Trial name
- CTI-HD (NCT02367430)
- Testing
- Critical Time Intervention With Buried in Treasures included
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
PANS, PANDAS
Antibiotic Treatment Trial for the PANDAS/PANS Phenotype
The purpose of this research study is to know if the antibiotic azithromycin, an antibiotic approved by the U.S. Food and Drug Administration (FDA) for treating infections, improves symptom severity in children with sudden and…
- Conditions
- PANS, PANDAS, Obsessive Compulsive Disorder (OCD)
- Trial name
- AZT (NCT01617083)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of South Florida
Obsessive Compulsive Disorder
Transcranial Magnetic Stimulation (TMS) in Obsessive Compulsive Disorder (OCD): Mechanisms and Biomarkers
The purpose of this study is to test the efficacy of 1-Hz repetitive transcranial magnetic stimulation (TMS) over the pre-supplementary motor area as a treatment for obsessive compulsive disorder.
- Trial name
- TMSOCD (NCT02355002)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Memantine Augmentation in Obsessive-Compulsive Disorder
The purpose of this study is to determine whether memantine is safe and effective when used as an augmentation to standard treatment for Obsessive-Compulsive Disorder (OCD).
- Trial name
- NCT00264238
- Testing
- Memantine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD
The investigators want to learn more about how human beings learn not to fear and the impact of changing the fear network in the brain using transcranial Direct Current Stimulation (tDCS) in individuals with obsessive compulsive…
- Trial name
- NCT05521074
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Massachusetts General Hospital
Hoarding Disorder, Hoarding
Enhancing Treatment of Hoarding Disorder With Personalized In-Home Sorting and Decluttering Practice
The proposed study aims to investigate the efficacy of adding in-home decluttering practice to Buried in Treasures Workshop (BIT) facilitated group treatment for hoarding disorder.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Trial name
- BITS (NCT02843308)
- Testing
- Facilitated group therapy with behavioral practice; 18 weeks
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Neurotic Excoriation, Pathologic Skin Picking
Double-Blind Lamictal (Lamotrigine) in Neurotic Excoriation
The goal of the proposed study is to evaluate the comparative efficacy of Lamictal (lamotrigine) to placebo in neurotic excoriation.
- Conditions
- Neurotic Excoriation, Pathologic Skin Picking, Psychogenic Excoriation, Dermatillomania
- Trial name
- NCT00513019
- Testing
- Lamictal (lamotrigine)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Trichotillomania
Feasibility Study for Treating Trichotillomania With Wearable Device and App System
Trichotillomania is characterized by recurrent hair pulling resulting in hair loss causing significant distress and impairment which persists despite repeated attempts to stop.
- Trial name
- NCT04241120
- Testing
- Device and app system designed for participant to self-administer Habit Reversal Training, Reminder bracelet control condition
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HabitAware Inc.
Obsessive-Compulsive Disorder
Treatment of Obsessive Compulsive Disorder in Children
This study will determine whether cognitive behavioral therapy delivered by either psychologists or psychiatrists can improve the effectiveness of serotonin reuptake inhibitor treatment in children with obsessive compulsive…
- Trial name
- NCT00074815
- Testing
- Serotonin reuptake inhibitors management, Cognitive behavioral therapy by a psychologist, Instructional cognitive behavioral therapy by a psychiatrist
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- Duke University
Hoarding Disorder
Augmenting Buried in Treasures Workshop (BIT) With In-home Decluttering Practice for Individuals With Hoarding Disorder
Patients participate in Buried in Treasures Workshop (BIT) that has been shown to improve symptoms of hoarding disorder. To target levels of clutter, the investigators are testing an intervention to add in-home decluttering…
- Trial name
- NCT02377986
- Testing
- BIT+in-home decluterring, In-Home Decluttering
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Hoarding Disorder, Hoarding
Hoarding Disorder Treatment With Virtual Reality
This study explores whether a facilitated peer support group called Buried in Treasures (BIT) and a virtual reality decluttering practice can help individuals with clutter challenges.
- Conditions
- Hoarding Disorder, Hoarding, Clutter
- Trial name
- HDVR (NCT03828461)
- Testing
- Facilitated group therapy with behavioral practice; 16 weeks
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCD
Obsessive-compulsive disorder (OCD) is a common illness that causes significant distress and impairment. Currently, serotonin reuptake inhibitors (SRIs) are the only medications that are FDA-approved to treat OCD.
- Trial name
- NCT02206776
- Testing
- Intranasal Ketamine, Intranasal Midazolam
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- New York State Psychiatric Institute
OCD, Decision-Making
Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation
People utilize two behavioral strategies, goal-directed and habitual, when engaging in value-based decision-making that involves rewarding or punishing outcomes.
- Conditions
- OCD, Decision-Making, tDCS, fMRI
- Trial name
- NCT04075890
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder
Effectiveness of D-Cycloserine as an Aid to Enhance Learning for Individuals With OCD Receiving Behavior Therapy
This study will assess the effectiveness of Seromycin (D-cycloserine) in enhancing the positive effects of behavior therapy for people with Obsessive-Compulsive Disorder (OCD).
- Trial name
- NCT00182000
- Testing
- seromycin, Behavior Therapy
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Obsessive Compulsive Disorder (OCD)
Cognitive Behavioral Strategies and Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder: Open Label Study
The purpose of this study is to evaluate the effectiveness of repetitive TMS (rTMS) delivered simultaneously with elements of cognitive behavioral therapy/exposure-response prevention (CBT/ERP) in adult subjects (greater or equal…
- Trial name
- CBT-TMS (NCT02528331)
- Testing
- Transcranial magnetic stimulation, Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University