Clinical trials: Obsessive Compulsive Disorders
Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder
CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD
The purpose of this study is to examine whether youth with OCD who benefit from CBT augmentation to SRI can discontinue their medication without relapse over 24 weeks.
- Conditions
- Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence
- Trial name
- NCT05609916
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Anxiety, Depression
The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective.
The combination of pharmacotherapy and individual cognitive behavioral therapy in a private practice.
- Conditions
- Anxiety, Depression, Obsessive-compulsive Disorder, Personality Disorder
- Trial name
- RAKGEOCBT (NCT06993662)
- Testing
- Group A. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by anxiety disorders and depression., Group B. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by PTSD, Group C. The combination of pharmacotherapy and individual cognitive behavioral psychotherapy by obsessive-compulsive disorder.
- Where
- Greece
- Volunteers
- 107 people
- Sponsor
- Rakitzi, Stavroula
High Risk, Depression / Major Depressive Disorder
Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders
This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and…
- Conditions
- High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder
- Trial name
- TRACE (NCT07744490)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder (OCD)
Preliminary Explorative Study of Magnetic Resonance-Guided Focused Ultrasound Surgery in Refractory Obsessive-Compulsive Disorder Patients
The goal of this clinical trial is to evaluate If magnetic resonance-guided focused ultrasound works to treat refractory obsessive-compulsive disorder in adults.
- Trial name
- NCT06816511
- Testing
- magnetic resonance-guided focused ultrasound surgery, MRgFUS
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Obsessive Compulsive Disorder (OCD), Pediatric Anxiety Disorders
Testing Delivery Modalities of Team-Based CBT for Pediatric Anxiety in Community Health Settings.
The purpose of this study is to test how the delivery of Cognitive Behavioral Therapy (CBT) for pediatric anxiety and OCD via different methods might increase its availability and effectiveness.
- Conditions
- Obsessive Compulsive Disorder (OCD), Pediatric Anxiety Disorders, Anxiety Disorder, Anxiety
- Trial name
- IMPACT-RI (NCT06934525)
- Testing
- Team-delivered, exposure-based CBT
- Where
- United States
- Volunteers
- 501 people
- Sponsor
- Bradley Hospital
Obsessive-Compulsive Disorder (OCD)
Helping Adults With Obsessive-Compulsive Disorder Succeed at Work
The purpose of this study is to compare two models of employment services for people with obsessive-compulsive disorder (OCD) interested in finding and maintaining employment.
- Trial name
- NCT07124780
- Testing
- Individual Placement and Support (IPS), Standard Vocational Services
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Brain Recordings in Patients Undergoing Deep Brain Stimulation (DBS) for Severe Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder effects approximately 2-3% of the population. The only established first-line treatments for OCD are cognitive-behavioral therapy (CBT) with exposure/response prevention and serotonin reuptake…
- Trial name
- NCT05915741
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence
Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD
Anxiety disorders in children and adolescents are common and confer significant disability. Cognitive behavioral therapy (CBT) is the recommended treatment for youth with anxiety, yet many families cannot access CBT due to cost…
- Conditions
- Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence, Social Anxiety Disorder of Childhood, Generalized Anxiety Disorder (GAD)
- Trial name
- ASTRO (NCT07024758)
- Testing
- Parent Coached Exposure Therapy, Family Based, Internet-Based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Baylor College of Medicine
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder)
Epidiolex in Obsessive Compulsive Disorder and Related Disorders
The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs).
- Conditions
- Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
- Trial name
- NCT04978428
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Chicago
Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal
Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD)
Obsessive-Compulsive Disorder and Tic Disorders frequently co-occur, and a subgroup of patients - those with a Tourettic Subtype of OCD (TOCD) - present with concurrent obsessive-compulsive and tic symptoms.
- Conditions
- Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal, Tic Disorders, Tic Disorder, Combined Vocal and Multiple Motor
- Trial name
- TORCH (NCT07725926)
- Testing
- Exposure and Response Prevention (ERP), Habit Reversal Training (HbRT, Psychoeducation and Supportive Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College London Hospitals
Obsessive Compulsive Disorder
SONATA LIFU for OCD
The study tests ATTN201, an investigational non-invasive headband that delivers low-intensity focused ultrasound (LIFU) to the subthalamic nucleus (STN) as a treatment for obsessive-compulsive disorder (OCD).
- Trial name
- NCT07728994
- Testing
- Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Obsessive Compulsive Disorder (OCD), Neuromodulation
Neurophysiological Investigation of the Approach-avoidance Axis in OCD: Applications to Neuromodulation
We will recruit 10 patients with OCD meeting established criteria for surgical evaluation. Following informed consent and baseline evaluations, each will be implanted with permanent DBS SenSight leads and the Medtronic Percept RC…
- Trial name
- NCT06596447
- Testing
- Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Obsessive Compulsive Disorder (OCD)
Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder
Obsessive-compulsive disorder (OCD) is associated with substantial impairments in quality of life and is among the most disabling psychiatric disorders.
- Trial name
- NCT06834217
- Testing
- Active transcranial direct current stimulation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Obsessive-Compulsive Disorder
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
The study tries to improve our treatments for people who have obsessive-compulsive disorder (OCD) by testing psilocybin, a mind altering drug that changes activity in brain areas involved in OCD.
- Trial name
- Mushroom-OCD (NCT07347405)
- Testing
- Psilocybin 10 mg, Psilocybin 20 mg, Psilocybin 30 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Francisco A Moreno
Obsessive-Compulsive Disorder
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder
This randomized controlled trial aims to evaluate the effects of digital mindfulness-based therapy in people with obsessive-compulsive disorder and to explore its possible psychological and neurophysiological mechanisms.
- Trial name
- dMBT-OCD (NCT07701616)
- Testing
- Digital Mindfulness-Based Therapy, Routine Pharmacological Treatment
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Central South University
Major Depressive Disorder, Obsessive-Compulsive Disorder
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe.
- Conditions
- Major Depressive Disorder, Obsessive-Compulsive Disorder, Schizophrenia, Generalized Anxiety Disorder
- Trial name
- Expedition (NCT06376734)
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Brigham and Women's Hospital
OCD, Obsessive-Compulsive Disorder (OCD)
Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Treatment Refractory Obsessive Compulsive Disorder (OCD)
This study evaluates the safety, feasibility, and preliminary efficacy of focused ultrasound (FUS) neuromodulation delivered using the Next Generation Dome Helmet (NGDH) in participants with treatment-refractory…
- Conditions
- OCD, Obsessive-Compulsive Disorder (OCD), Obsessive-Compulsive Disorder
- Trial name
- NCT07704632
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Obsessive-Compulsive Disorder, Pediatric Psychiatric Disorder
Transcranial Direct Current Stimulation (tDCS) in Pediatric Obsessive Compulsive Disorder (OCD)
In this study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in modulating aberrant neurocognitive processes implicated in pediatric patients with obsessive compulsive disorder…
- Trial name
- NCT04548609
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Study on the Efficacy Mechanism of Natural Psychotherapy for Neurosis
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
- Trial name
- NCT05552014
- Testing
- Natural Psychotherapy, waitlist control group
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital