Clinical trials: Obsessive Compulsive Disorders
Obsessive-Compulsive Disorder
An OCD Prevention Programme for at Risk Adults
The main purpose of this randomised clinical trial is to test the efficacy of a prevention program for adult who are at risk of developing OCD, thus constituting a form of tertiary prevention.
- Trial name
- ØCD (NCT06262464)
- Testing
- Prevention
- Where
- Romania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Obsessive-Compulsive Disorder
esTOCma, an App Used by Teachers: an RCT
The aim of the present study is to assess the efficacy of a mobile application called esTOCma in promoting mental health literacy, reducing stigmatizing attitudes related to the Obsessive-Compulsive Disorder (OCD) and improving…
- Trial name
- NCT06334887
- Testing
- Use of esTOCma
- Where
- Spain
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Obsessive-Compulsive Disorder
Predicting Treatment Response in Patients With OCD
This study consists of a naturalistic follow-up of subjects with Obsessive-Compulsive Disorder (OCD) that have participated in a global study investigating brain signatures of OCD funded by the National Institutes of Mental…
- Trial name
- NCT03993535
- Testing
- selective serotonin reuptake inhibitor
- Where
- 4 sites in United States, Brazil and 2 more
- Volunteers
- 250 people
- Sponsor
- University of Sao Paulo
Obsessive-Compulsive Disorder, OCD
Personalized DBS for OCD Guided by Stereoencephalography Mapping
This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months.
- Trial name
- NCT06347978
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Andrew Moses Lee, MD, PhD
Obsessive Compulsive Disorder
Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder
The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional components of behavior that more…
- Trial name
- NCT03451409
- Testing
- Tasked based functional MRI (fMRI), Eye Tracking Device
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Obsessive-Compulsive Disorder
Efficacy of Nitrous Oxide in OCD: Pilot Study
This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.
- Trial name
- NCT03826693
- Testing
- Nitrous Oxide, Nitrogen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Obsessive Compulsive Disorder
Treating Refractory Obsessive Compulsive Disorder With rTMS
Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with only limited response to current first-line treatments, comprising pharmacotherapy and cognitive-behavioural therapy.
- Trial name
- NCT00396552
- Testing
- refractory transcranial magnetic stimulation (rTMS)
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- Centre for Addiction and Mental Health
Anxiety, Anxiety Acute
Anxiety Skills Study
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training…
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders
- Trial name
- NCT07774481
- Testing
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Ohio State University
Obsessive-Compulsive Disorder, Burns
OCD Among Patients With Burns
Estimating the prevalence of OCD symptoms among patients with burns
- Trial name
- NCT00294983
- Where
- Israel
- Sponsor
- Sheba Medical Center
Major Depressive Disorder, Bipolar Disorder
Chart Review of Patients Undergoing Ketamine Infusions
The Canadian Rapid Treatment Center of Excellence (CRTCE) is a healthcare facility principally focused on providing best practices of intravenous ketamine treatment to adult patients suffering from mental health conditions.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT04209296
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 891 people
- Sponsor
- Brain and Cognition Discovery Foundation
Obsessive-Compulsive Disorder
Personalized Computerized Inhibitory Control Training for OCD
This study will evaluate the effects of a computerized training program coupled with cognitive behavioral therapy (CBT) for OCD.
- Trial name
- NCT02378896
- Testing
- Personalized Computer Program, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Efficacy Study of add-on Therapy With N-Acetylcysteine in Resistant Obsessive-compulsive Disorder
The primary objective of this study is to determine if N-Acetylcysteine (NAC) has efficacy as an augmentation agent in the treatment of treatment-resistant obsessive-compulsive disorder (OCD).
- Trial name
- NACTOC (NCT01555970)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obsessive Compulsive Disorder
D-Cycloserine Augmentation to CBT With Exposure and Response Prevention in Adults and Adolescents With OCD
This is a single site, open-label, feasibility study of cognitive behavioral therapy with exposure and response prevention (CBT/ERP) adding the augmentation of D-cycloserine (DCS) for adolescents ages 12-17 with Obsessive…
- Trial name
- NCT01172873
- Testing
- D-cycloserine, Exposure and Response Prevention (EX/RP)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-compulsive Disorders and Symptoms
Assessing Models of Exposure Therapy
The objective of this study is to learn how to improve treatment for clients who are working hard in treatment at the McLean Hospital Obsessive Compulsive Disorder Institute (OCDI), but who are not making the progress that would…
- Trial name
- NCT01679457
- Testing
- ACT-Focused ERP, TAU-ERP
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mclean Hospital
Romano-Ward Syndrome, Long QT Syndrome
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.
The objectives of the study are to investigate if KCNQ1 mutation in Romano-Ward long QT patients can be associated with changes in insulin regulation and with psychological features of compulsivity, impulsivity and behavioural…
- Conditions
- Romano-Ward Syndrome, Long QT Syndrome, Compulsive Behavior, Healthy Individuals
- Trial name
- PRIME (NCT04715256)
- Testing
- Cognitive assessment of obsessive-compulsive and impulsive behaviours, Genomic analysis, Glucoregulation assessment
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biotrial
Obsessive-Compulsive Disorder
Evaluating Unilateral Deep Brain Stimulation in Patients With Obsessive Compulsive Disorder
The investigators previously showed that deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BNST) reduces symptoms in patients with severe obsessive-compulsive disorder (OCD).
- Trial name
- NCT03894397
- Testing
- Electrical stimulation of the BNST
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- KU Leuven
Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal
Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD)
Obsessive-Compulsive Disorder and Tic Disorders frequently co-occur, and a subgroup of patients - those with a Tourettic Subtype of OCD (TOCD) - present with concurrent obsessive-compulsive and tic symptoms.
- Conditions
- Obsessive - Compulsive Disorder, Tic Disorder, Chronic Motor or Vocal, Tic Disorders, Tic Disorder, Combined Vocal and Multiple Motor
- Trial name
- TORCH (NCT07725926)
- Testing
- Exposure and Response Prevention (ERP), Habit Reversal Training (HbRT, Psychoeducation and Supportive Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College London Hospitals
Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder
Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)
A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) and/or tic disorders has been identified who share a common clinical course characterized by dramatic onset and symptom exacerbations following group…
- Conditions
- Mental Disorder Diagnosed in Childhood, Obsessive Compulsive Disorder, Streptococcal Infection, Tic Disorder
- Trial name
- NCT00001359
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder
TMS + Exposure Therapy for Pediatric OCD
The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive…
- Trial name
- NExT (NCT05931913)
- Testing
- Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex, Exposure with Response Prevention, Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Bradley Hospital