AnxietyNCT07774481
Anxiety Skills Study
A study testing Cognitive therapy, Behavioral therapy and Mindfulness-based therapy in people with Anxiety and Anxiety Acute, run by Ohio State University at 1 site in United States.
Trial summary
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training compared to receiving 4 sessions of therapy, and (3) to evaluate how durable these effects… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Anxiety, Anxiety Acute, Anxiety Chronic
- What is being tested?
- Cognitive therapy, Behavioral therapy and Mindfulness-based therapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 600 participants
- Where
- 1 siteUnited States
- Study dates
- 20 Oct 2025to 31 Aug 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Presence of clinically elevated anxiety
- Living in Ohio
Who cannot join
- No access to a smartphone
- Presence of conditions that would necessitate alternative care
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Psychology Building at Ohio State University
Columbus, Ohio, 43210
Matt Southward, PhD, 614-247-0331, mattlabatosu@gmail.com
About this study
Official title: Personalizing and Optimizing CBT Skills for Anxiety
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training compared to receiving 4 sessions of therapy, and (3) to evaluate how durable these effects are over 1 year.
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders, Social Anxiety Disorder, Panic Disorder (With or Without Agoraphobia)
- Being tested
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Keywords
- anxiety, CBT, treatment
- Medical subject headings
- Anxiety Disorders, Mood Disorders, Phobia, Social, Panic Disorder, Generalized Anxiety Disorder, Obsessive-Compulsive Disorder, Phobia, Specific
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive therapyBehavioural
Cognitive therapy involves identifying and challenging negative automatic thoughts.
Behavioral therapyBehavioural
Behavioral therapy involves identifying emotional urges and acting opposite to those urges.
Mindfulness-based therapyBehavioural
Mindfulness-based therapy involves cultivating nonjudgmental present-moment awareness of thoughts, feelings, and behaviors.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive therapy | Active comparator | Not described Receives: Behavioral: Cognitive therapy |
| Behavioral therapy | Active comparator | Not described Receives: Behavioral: Behavioral therapy |
| Mindfulness-based therapy | Active comparator | Not described Receives: Behavioral: Mindfulness-based therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Overall Anxiety Severity and Impairment Scale (OASIS)
Minimum value: 0. Maximum value = 20. High scores mean worse outcomes.
Measured: Weekly for 6 weeks, then monthly for 1 year.
Secondary outcomes (1)
Overall Depression Severity and Impairment Scale (ODSIS)
Minimum = 0. Maximum = 20. Higher scores mean worse outcomes.
Measured: Weekly for 6 weeks, then monthly for 1 year.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Aug 2026
- Study start20 Oct 2025
- Primary completion31 Aug 2029 (estimated)
- Study completion31 Aug 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnxietyStudies of the same condition, open and under way.
- More trials run by Ohio State UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 600 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ohio State University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Matthew Southward, PhD, Ohio State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07774481
- Sponsor's protocol ID
- STUDY20251236
- Status last verified
- Aug 2026
- First submitted
- 14 Aug 2026
- Last updated
- 19 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: We plan to share participants' condition and primary and secondary outcome data, although, given the ending of Open Science Framework support for this sharing, we are undecided about where and how we will share this data.
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Personalizing and Optimizing CBT Skills for Anxiety
- ClinicalTrials.gov ID
- NCT07774481
- Acronym / sponsor ID
- STUDY20251236
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders, Social Anxiety Disorder, Panic Disorder (With or Without Agoraphobia)
- Keywords
- anxiety, CBT, treatment
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 600 participants (estimated)
- Lead sponsor
- Ohio State UniversityUniversity, hospital or other
- Study start
- 20 Oct 2025 (actual)
- Primary completion
- 31 Aug 2029 (estimated)
- Study completion
- 31 Aug 2030 (estimated)
- First posted
- 19 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training compared to receiving 4 sessions of therapy, and (3) to evaluate how durable these effects are over 1 year.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Cognitive therapy | Active comparator | Behavioral: Cognitive therapy |
| Behavioral therapy | Active comparator | Behavioral: Behavioral therapy |
| Mindfulness-based therapy | Active comparator | Behavioral: Mindfulness-based therapy |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Presence of clinically elevated anxiety
- Living in Ohio
Key exclusion criteria (2 listed)
- No access to a smartphone
- Presence of conditions that would necessitate alternative care
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive therapyCognitive therapy involves identifying and challenging negative automatic thoughts. | Behavioural | Cognitive therapy |
| Behavioral therapyBehavioral therapy involves identifying emotional urges and acting opposite to those urges. | Behavioural | Behavioral therapy |
| Mindfulness-based therapyMindfulness-based therapy involves cultivating nonjudgmental present-moment awareness of thoughts, feelings, and behaviors. | Behavioural | Mindfulness-based therapy |
Primary outcome
Overall Anxiety Severity and Impairment Scale (OASIS)
Time frame: Weekly for 6 weeks, then monthly for 1 year.
Minimum value: 0. Maximum value = 20. High scores mean worse outcomes.
1 secondary outcome
Overall Depression Severity and Impairment Scale (ODSIS)
Time frame: Weekly for 6 weeks, then monthly for 1 year.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
- Lab website with brief study description and link to pre-screening formLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided. We plan to share participants' condition and primary and secondary outcome data, although, given the ending of Open Science Framework support for this sharing, we are undecided about where and how we will share this data.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive therapy, Behavioral therapy and Mindfulness-based therapy in people with Anxiety and Anxiety Acute, run by Ohio State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Study Coordinator, PhD (614-398-1624, anxietyskillsstudy@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Overall Anxiety Severity and Impairment Scale (OASIS) (time frame: Weekly for 6 weeks, then monthly for 1 year.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.