Clinical trials: Obsessive Compulsive Disorder (OCD)
Obsessive Compulsive Disorder
Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
This study will examine the feasibility and potential efficacy of augmenting SRIs with minocycline. The study will assess whether the addition of minocycline leads to measurable changes in striatal glutamate (Glu) levels.
- Trial name
- NCT01695291
- Testing
- Minocycline
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-compulsive Disorder
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomatic upon treatment completion.
- Trial name
- NCT00864123
- Testing
- Cognitive-behavioral therapy, D-cycloserine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obsessive Compulsive Disorder
Pilot Study of Minocycline (NPL-2003) in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform…
- Trial name
- NCT00728923
- Testing
- NPL-2003
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Using Virtual Reality Before Transcranial Magnetic Stimulation for the Treatment of OCD
This study will focus on the use of Virtual Reality (VR) technology in patients receiving treatment using Transcranial Magnetic Stimulation (TMS) for Obsessive-Compulsive Disorder (OCD)
- Trial name
- VR-TMS (NCT06442527)
- Testing
- Virtual Reality
- Where
- United States
- Sponsor
- Yale University
Obsessive-compulsive Disorder
Electrophysiological Recording for Patients Receiving Deep Brain Stimulation Electrode for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this project is to study live recordings from neuronal population of the human nucleus accumbens during the implantation of deep brain stimulation (DBS) electrodes for the treatment-resistant obsessive compulsive…
- Trial name
- NCT01429558
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obsessive-Compulsive Disorder (OCD)
Metacognitive Therapy for Obsessive-Compulsive Disorder
Cognitive behavior therapy is the most effective treatment of obsessive-compulsive disorder. However, the majority of treated patients remain symptomatic.
- Trial name
- NCT02867449
- Testing
- Metacognitive Therapy, Exposure and Response Prevention
- Where
- 2 sites in Germany
- Volunteers
- 74 people
- Sponsor
- University of Leipzig
Major Depressive Disorder, Generalized Anxiety Disorder
The Modular Protocol for Mental Health (MPMH)
Currently, our best psychological treatments for anxiety and mood disorders only focus on individual diagnoses. So, there are separate treatments for Panic Disorder, or Depressive Disorder, or Social Anxiety, etc.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- MPMH (NCT03143634)
- Testing
- The Modular Protocol for Mental Health, Treatment-as-usual
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Obsessive-Compulsive Disorder
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- PAP-OCD (NCT06299319)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder
The objective of this study was to obtain preliminary open-label data on the efficacy and tolerability of memantine, an anti-glutamatergic medication with a unique pharmacodynamic profile, in individuals with OCD and individuals…
- Trial name
- NCT00674219
- Testing
- Memantine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Obsessive-Compulsive Disorder
Probiotic Treatment in Adult Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of 12-weeks of probiotic treatment in adults with primary Obsessive-Compulsive Disorder and whether this treatment will alter the microbiota composition in these patients.
- Trial name
- NCT02334644
- Testing
- Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Tourette Syndrome, Obsessive-Compulsive Disorder
Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what…
- Conditions
- Tourette Syndrome, Obsessive-Compulsive Disorder, Sensory Disorders
- Trial name
- SenST-Plus (NCT04335175)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Anxiety, Anxiety Acute
Anxiety Skills Study
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training…
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders
- Trial name
- NCT07774481
- Testing
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Ohio State University
Obsessive-Compulsive Disorder
EEG Evaluation of CBT for Obsessive-Compulsive Disorder
This clinical trial investigates how Cognitive Behavioral Therapy (CBT), a psychological treatment that helps people change their thought and behavior patterns, affects brain function in people diagnosed with Obsessive-Compulsive…
- Trial name
- CBT-OCD-EEG (NCT07000812)
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Hoarding Disorder
Motivational Interviewing to Enhance Behavioral Change in Older Adults With Hoarding Disorder
This study will compare two behavioral interventions for hoarding disorder in older adults.
- Trial name
- NCT05237466
- Testing
- RECLAIM: Reducing Clutter and Increasing Meaning, Sorting Practice
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mississippi State University
Obsessive-Compulsive Disorder
Towards Personalized Medicine for OCD
Obsessive compulsive disorder (OCD) is one of the most disabling anxiety disorders occurring in about 2 out of a 100 adults. Untreated, OCD is a chronic and deteriorating condition, negatively impacting multiple areas of life…
- Trial name
- NCT03852186
- Testing
- Cognitive behavioral therapy, Acceptance and commitment therapy
- Where
- Denmark
- Volunteers
- 178 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obsessive Compulsive Disorder (OCD)
NAC for Treatment-Resistant OCD and Other Related Disorders
This is a randomized, double-blind, placebo-controlled study investigating N-acetylcysteine (NAC) as an augmentation therapy for individuals with treatment-resistant obsessive-compulsive disorder (TR-OCD), studied within a…
- Trial name
- NCT06956157
- Testing
- N-Acetylcysteine Tablets
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Obsessive Compulsive Disorder (OCD)
Cognitive Behavioral Strategies and Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder: Open Label Study
The purpose of this study is to evaluate the effectiveness of repetitive TMS (rTMS) delivered simultaneously with elements of cognitive behavioral therapy/exposure-response prevention (CBT/ERP) in adult subjects (greater or equal…
- Trial name
- CBT-TMS (NCT02528331)
- Testing
- Transcranial magnetic stimulation, Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Obsessive-Compulsive Disorder
Immersive Virtual Reality & Obsessive Compulsive Disorder
Immersive VR (IVR) is based on the generation and projection of images from different perspectives. Obsessive Compulsive Disorder (OCD) is considered one of the 5 most common mental disorders and one of the 20 most disabling…
- Trial name
- NCT05841017
- Testing
- Psychotherapy with Immersive Virtual Reality support.
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Consorci Hospitalari de Vic
Obsessive Compulsive Disorder
Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
This study involves the use of the Medtronic PC+S deep brain stimulation for the treatment of intractable OCD.
- Trial name
- NCT03184454
- Testing
- Medtronic Percept Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
A Wearable AI Feedback Tool for Pediatric OCD
To test the feasibility of implementing digitally enhanced psychotherapy and research in a community child and adolescent mental health center including the acceptability of the digital technology to patients, parents and…
- Trial name
- NCT05064527
- Testing
- wearable biosensor, Treatment as usual (TAU), Exposure and response prevention (ERP)
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital