Clinical trials: Obsessive Compulsive Disorder (OCD)
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Obsessive-Compulsive Disorder
Study on the Efficacy Mechanism of Natural Psychotherapy for Neurosis
explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder
- Trial name
- NCT05552014
- Testing
- Natural Psychotherapy, waitlist control group
- Where
- 2 sites in China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Obsessive Compulsive Disorder
Computer Assisted Cognitive Behavior Therapy for Obsessive Compulsive Disorder: A Comprehensive Stepped-Care Approach
The goal of this project is to improve access to effective treatments for obsessive compulsive disorder (OCD) through the use of web-based cognitive behavioral therapy (CBT) treatment.
- Trial name
- NCT01522287
- Testing
- Computer-Assisted Cognitive Behavior Therapy (BT STEPS)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Center for Psychological Consultation
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Adult ALL, Post-traumatic Stress Disorder
Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
The Eye Movement Desensitization and Reprocessing Protocol (EMDR) was first developed by Francine Shapiro in 1987 and can be adapted for online and in presence administration.
- Conditions
- Adult ALL, Post-traumatic Stress Disorder, Obsessive-Compulsive Disorder, Disgust
- Trial name
- MDL (NCT06110702)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Obsessive-Compulsive Disorder
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
- Trial name
- AvoidOCD (NCT04685018)
- Testing
- fMRI acquisition
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Obsessive - Compulsive Disorder
Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD
The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area…
- Trial name
- NCT07480408
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Obsessive Compulsive Disorder
Cost-Effectiveness of Adding Web-Based Cognitive-Behavioral Therapy (CBT) to Luvox CR for Obsessive Compulsive Disorder (OCD)
This study will test the hypotheses that: 1. 12 weeks of Luvox-CR plus web-based Cognitive-Behavioral Therapy (CBT) [CT-STEPS] will produce greater symptom relief of OCD than treatment with Luvox-CR alone; and, 2.
- Trial name
- NCT00743834
- Testing
- Luvox CR, Behavioral Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rogers Center for Research & Training, Inc.
Obsessive-Compulsive Disorder, Cognitive Flexiblity
Cognitive Flexibility and Response to TMS Therapy
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option for treatment-resistant obsessive-compulsive disorder.
- Trial name
- CogFlexTMS (NCT06769243)
- Testing
- TMS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Obsessive-Compulsive Disorder
Decision-making Impairments in OCD: An Integrated Behavioral Economics Model
The investigators are examining whether conditions of ambiguity during decision-making may prime intolerance of uncertainty beliefs (i.e., difficulties coping with ambiguity, unpredictability, and the future) and lead to impaired…
- Trial name
- NCT03420495
- Testing
- Decision-Making Tasks
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Body Dysmorphic Disorder, Obsessive-compulsive Disorder
Oxytocin Administration in BDD and OCD
The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and…
- Trial name
- NCT02671266
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hoarding Disorder
Neural Mechanisms of Decision Making in Hoarding Disorder
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.
- Trial name
- LOSS (NCT03487224)
- Testing
- MRI with fMRI frequency
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obsessive-compulsive Disorder
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomatic upon treatment completion.
- Trial name
- NCT00864123
- Testing
- Cognitive-behavioral therapy, D-cycloserine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Depression, Panic Disorder
Evaluating the Effects of Stress in Pregnancy
This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy.
- Conditions
- Depression, Panic Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00525226
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- Emory University
Anxiety, Obsessive Compulsive Disorder
Virtual Reality System to Increase Access to Exposure Therapy for Anxiety and OCD
Cognitive Behavioral Therapy with fear provoking exposures is the most effective therapy for anxiety disorders. Investigators aim to enhance this therapy with the use of virtual reality exposures and to make therapy more…
- Trial name
- NCT02713516
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obsessive-Compulsive Disorder, Anxiety Disorders
Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients
The purpose of this study is to evaluate the efficiency of SSRIs（Selective Serotonin Reuptake Inhibitor） ,ERP（Exposure and Response Prevention） and the combination of the two therapies for OCD(Obsessive-Compulsive Disorder)…
- Conditions
- Obsessive-Compulsive Disorder, Anxiety Disorders, Mental Disorders
- Trial name
- NCT02022709
- Testing
- Fluoxetine, Sertraline, Paroxetine
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
OCD, Obsessive-Compulsive Disorder
Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)
The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically relevant contexts.
- Trial name
- ABOVE (NCT03459456)
- Testing
- Provocation OC task (Provoc), Trier Social Stress Test (TSST), Exposure provocation task
- Where
- 3 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD)
Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder
This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder.
- Conditions
- Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD), Obsessive Compulsive Behavior, Substance Abuse Disorder
- Trial name
- NCT07395453
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Assiut University
Obsessive-Compulsive Disorder
Control and Reward Circuits in Obsessive Compulsive Disorder
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02221518
- Testing
- Exposure & Response Prevention (EX/RP)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute