Hoarding DisorderLOSSNCT03487224
Neural Mechanisms of Decision Making in Hoarding Disorder
An observational study of Hoarding Disorder, run by Stanford University at 1 site in United States.
Trial summary
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder. Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Hoarding Disorder
- What is being tested?
- MRI with fMRI frequency
- Type of treatment
- Medical device
- How many people
- 25 participants
- Where
- 1 siteUnited States
- Study dates
- 8 Jul 2018to 30 May 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Individuals with Hoarding Disorder and Healthy Participants
Who may be able to join
- ages 18-70
- primary diagnosis of hoarding disorder
- sufficient severity of hoarding symptoms
- stable on psychotropic medications for 1 month prior to study enrollment
- capacity to provide informed consent
- ability to tolerate clinical study procedures
Show all 9Show fewer
- ages 18-70
- capacity to provide informed consent
- Identify exclusion criteria.
Who cannot join
- psychiatric or medical conditions that make participation unsafe
- pregnant or nursing females
- concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
- presence of metallic device or dental braces
- any current or lifetime psychiatric diagnosis
- current or past use of psychotropic medication
Show all 9Show fewer
- pregnant or nursing females
- major medical or neurological problem
- presence of metallic device or dental braces
Trial locations and contacts
1 site in 1 country.
About this study
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.
Read the detailed description
Hoarding disorder is a common and disabling disorder that represents a significant public health problem. This study aims to build on current research on decision making by examining these processes in hoarding disorder.
- Conditions
- Hoarding Disorder
- Being tested
- MRI with fMRI frequency
- Keywords
- Hoarding Disorder
- Medical subject headings
- Hoarding Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRI with fMRI frequencyDevice
Functional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI.
| Study group | Role | What they receive |
|---|---|---|
| Hoarding Disorder | Adults diagnosed with Hoarding Disorder Receives: Device: MRI with fMRI frequency | |
| Healthy Controls | Adults without mental illness Receives: Device: MRI with fMRI frequency |
What is being measured
The primary outcome is the main question the study is designed to answer.
BOLD signal
BOLD signal derived from fMRI
Measured: up to 90 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2018
- Study start8 Jul 2018
- Primary completion30 May 2027 (estimated)
- Study completion30 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hoarding DisorderStudies of the same condition, open and under way.
- More trials run by Stanford UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Stanford University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Carolyn Rodriguez, Stanford University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03487224
- Sponsor's protocol ID
- 42327
- Acronym
- LOSS
- Status last verified
- Aug 2026
- First submitted
- 27 Mar 2018
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural Mechanisms of Decision Making in Hoarding Disorder
- ClinicalTrials.gov ID
- NCT03487224
- Acronym / sponsor ID
- LOSS / 42327
- Conditions
- Hoarding Disorder
- Keywords
- Hoarding Disorder
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Stanford UniversityUniversity, hospital or other
- Study start
- 8 Jul 2018 (actual)
- Primary completion
- 30 May 2027 (estimated)
- Study completion
- 30 May 2027 (estimated)
- First posted
- 3 Apr 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to understand the neural mechanisms of decision making in hoarding disorder.
Detailed description
Hoarding disorder is a common and disabling disorder that represents a significant public health problem. This study aims to build on current research on decision making by examining these processes in hoarding disorder.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Hoarding Disorder | – | Device: MRI with fMRI frequencyAdults diagnosed with Hoarding Disorder |
| Healthy Controls | – | Device: MRI with fMRI frequencyAdults without mental illness |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Individuals with Hoarding Disorder and Healthy Participants
Key inclusion criteria (9 listed)
- ages 18-70
- primary diagnosis of hoarding disorder
- sufficient severity of hoarding symptoms
- stable on psychotropic medications for 1 month prior to study enrollment
- capacity to provide informed consent
Key exclusion criteria (9 listed)
- psychiatric or medical conditions that make participation unsafe
- pregnant or nursing females
- concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)
- presence of metallic device or dental braces
- any current or lifetime psychiatric diagnosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRI with fMRI frequencyFunctional magnetic resonance imaging or fMRI measures brain activity by detecting changes in blood flow. Participants will do cognitive tasks during fMRI. | Device | Healthy Controls, Hoarding Disorder |
Primary outcome
BOLD signal
Time frame: up to 90 minutes
BOLD signal derived from fMRI
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Stanford Medicine Faculty PageLink provided by the sponsor.
- Rodriguez Lab WebsiteLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hoarding Disorder, run by Stanford University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
BOLD signal (time frame: up to 90 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.