Clinical trials: Obsessive Compulsive Disorder, open to volunteers
Treatment-refractory Obsessive-compulsive Disorder (trOCD)
Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial)
One treatment for treatment-refractory OCD is a procedure called anterior capsulotomy, which modifies a part of the brain called the anterior limb of the internal capsule (ALIC).
- Trial name
- NCT07895706
- Testing
- Radiosurgical anterior capsulotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Obsessive-Compulsive Disorder
tDCS Associated With Symptom Provocation in the Management of Patients With Resistant Obsessive Compulsive Disorder
This is a single-center study about patients with severe resistant OCD. Main assumption is that performing 10 tDCS sessions with the anode positioned at the level of the right orbitofrontal cortex, and the cathode at the level of…
- Trial name
- PPSTDCS-TOC (NCT06017713)
- Testing
- tDCS + symptoms provocation
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive - Compulsive Disorder
tDCS and Symptom Provocation in Treatment-Resistant OCD
The goal of this clinical trial is to learn if symptom provocation before transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD) patients.
- Trial name
- PPS-TDCSTOC (NCT07429500)
- Testing
- tDCS session, symptom provocation
- Where
- 6 sites in France
- Volunteers
- 178 people
- Sponsor
- Centre Hospitalier Henri Laborit
Obsessive - Compulsive Disorder
SONATA Dose Duration LIFU for OCD
This study is testing a new, non-invasive brain stimulation approach for adults with Obsessive Compulsive Disorder (OCD). Researchers are evaluating the safety, tolerability, and target engagement of low-intensity focused…
- Trial name
- NCT07887633
- Testing
- ATTN201 - Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Obsessive Compulsive Disorder (OCD)
Gamified Combined Cognitive Bias Modification in Adults Diagnosed With OCD: Randomized Controlled Trial
This randomized controlled trial examines the effects of a mobile-based gamified combined cognitive bias modification (CBM-C) intervention on obsessive-compulsive symptoms, obsessive beliefs, attentional and interpretation…
- Trial name
- NCT06941155
- Testing
- Gamified-Combined Cognitive Bias Modification, Standard Combined Cognitive Bias Modification
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dokuz Eylul University
Obsessive Compulsive Disorder (OCD)
Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept Study
This research study is being conducted to study the use of artificial-intelligence powered virtual reality exposure therapy (AI-VRET) to treat college students with obsessive compulsive disorder (OCD).
- Trial name
- AI-VRET (NCT07877363)
- Testing
- Traditional Exposure and Response Prevention (ERP), Artificial Intelligence-Powered Virtual Reality Exposure Therapy (AI-VRET)
- Volunteers
- 24 people
- Sponsor
- University of California, San Diego
Obsessive Compulsive Disorder (OCD)
Low-intensity Ultrasound for Individuals With Obsessive-compulsive Disorder
The goal of this clinical trial is to learn whether low-intensity focused ultrasound (LIFU), a non-invasive form of brain stimulation, can change brain activity and improve thinking and decision-making in adults with…
- Trial name
- LIFU-OCD (NCT07872917)
- Testing
- Low-intensity focused ultrasound (Active)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Obsessive-Compulsive Disorder (OCD)
A Digital Mindfulness-Based Program for OCD
Obsessive-Compulsive Disorder (OCD) is a common long-lasting, and disabling condition, affecting 1 in every 25 people in Portugal.
- Trial name
- MBCT-OCD (NCT07871344)
- Testing
- Mindfulness-based cognitive-behavioral therapy digital program
- Volunteers
- 128 people
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Obsessive-Compulsive Disorder
Project EMPOWER-OCD
This research study aims to adapt and evaluate the acceptability and effectiveness of Project EMPOWER-OCD for socioeconomically diverse caregivers of patients with OCD. Designed to reduce obstacles (e.g.
- Trial name
- NCT07158801
- Testing
- Project EMPOWER-OCD, Project CARE
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
ADHD, Obsessive Compulsive Disorder (OCD)
Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
Background: Attention deficit hyperactivity disorder (ADHD) is common in children. It can cause problems with attention and the ability to control actions and impulses.
- Conditions
- ADHD, Obsessive Compulsive Disorder (OCD), Healthy Volunteer
- Trial name
- NCT07566468
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder (OCD)
Feasibility of Modulating Cognitive Control in OCD
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD).
- Trial name
- NCT07419009
- Testing
- continuous theta-burst transcranial magnetic stimulation (cTBS)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Obsessive-Compulsive Disorder (OCD)
Neurobehavioral Investigations of Approach Dynamics in the Ventral Striatum
Traditional strategies for diagnosing psychiatric disorders focus on definitions based on constellations of co-occurring symptoms.
- Trial name
- NCT05422469
- Testing
- Medtronic Percept RC neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Obsessive Compulsive Disorder (OCD)
OCD LIFU Target Engagement
The investigators will conduct a pilot study to evaluate the safety and feasibility of low-intensity focused ultrasound on obsessive-compulsive disorder (OCD) symptoms when delivered to subcortical brain targets.
- Trial name
- NCT07558148
- Testing
- Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Focused Ultrasound for Behavioral Health
This is a double-blind, within-participant crossover, multi-site dose-finding study evaluating the safety, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound (LIFU) stimulation using the ATTN201…
- Conditions
- Depression, Anxiety, Obsessive Compulsive Disorder (OCD)
- Trial name
- VANTUS (NCT07851038)
- Testing
- ATTN201 head-worn focused ultrasound
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Attune Neurosciences Inc
Obsessive-Compulsive Disorder (OCD)
Aerobic Exercise and Obsessive-Compulsive Disorder Symptoms
The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective…
- Trial name
- NCT07103902
- Testing
- Moderate-Intensity Exercise, Low-Intensity Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Obsessive-Compulsive Disorder (OCD)
Acceptance and Commitment Therapy for Religious OCD
The purpose of the study is to examine the effects and feasibility of a specific form of psychotherapy, acceptance and commitment therapy (ACT), on religiously oriented obsessive and compulsive disorder (OCD).
- Trial name
- NCT06647589
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Typical Development, Obsessive Compulsive Disorder
Developing Brain, Impulsivity and Compulsivity
Background: Impulsivity is acting 'without thinking.' Compulsivity is being overly inflexible. People vary in how impulsive or compulsive they are. Extreme versions of these behaviors play a role in mental disorders.
- Conditions
- Typical Development, Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT04631042
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive - Compulsive Disorder
Clinical and Biological Correlates of Obsessive-Compulsive Disorder and Online Mindfulness-Based Cognitive Therapy
The study has two main objectives: (1) to evaluate the acceptability and feasibility of a specialized Mindfulness-Based Cognitive Therapy (MBCT) program for Obsessive-Compulsive Disorder (OCD), delivered via videoconference in a…
- Trial name
- MIND-DOC (NCT07834567)
- Testing
- Mindfulness-based Cognitive Therapy for OCD
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Obsessive-Compulsive Disorder
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response…
- Trial name
- NCT04131829
- Testing
- Fluoxetine - immediate treatment, Fluoxetine - delayed treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University