Clinical trials: Obesity and Obesity-related Medical Conditions
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance
Incretin mimetics are widely used pharmacological treatments for weight loss, known for their high efficacy and favorable safety profile.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Insulin Sensitivity/Resistance, Semaglutide
- Trial name
- TRIM-IR (NCT06856291)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- ETH Zurich
Bone Disease, Metabolic, Diabetes Mellitus, Type 2
Glucose-dependent INsulinotropic Polypeptide: Effect on Bone Remodelling and Cell Activity (GINEBRA)
Glucose-dependent insulinotropic polypeptide (GIP) is released by the intestines in response to food intake and increases insulin secretion.
- Conditions
- Bone Disease, Metabolic, Diabetes Mellitus, Type 2, Obesity and Obesity-related Medical Conditions
- Trial name
- GINEBRA (NCT06790225)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP)
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Obesity and Obesity-related Medical Conditions
Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss
This study examines whether adding tirzepatide-a medication that helps with weight loss-after sleeve gastrectomy surgery can help people lose more weight after the surgery; better improve conditions like Type 2 diabetes, high…
- Trial name
- NCT06734273
- Testing
- Mounjaro, Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Nicholas Skertich
Obesity and Obesity-related Medical Conditions, Bariatric Surgery
Transition to Ambulatory Bariatric Surgery (TABS) Trial
This study will compare same day discharge and at least one night stay in the hospital after bariatric surgery. Patients undergoing bariatric surgery will be randomized (i.e. have an equal chance of either plan) to either group.
- Trial name
- TABS (NCT07011628)
- Testing
- Same Day Discharge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Obesity and Obesity-related Medical Conditions
A Wearable Device and AI-Supported Diet and Exercise Intervention
This study implemented a personalized 6-month diet and exercise program to promote weight loss. Participants were recruited from outpatient clinics at the Department of Family Medicine, National Taiwan University Hospital.
- Trial name
- NCT06630663
- Testing
- A Wearable Device and AI-Supported Diet and Exercise intervention, standard care
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Appetite, Obesity and Obesity-related Medical Conditions
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite.
- Trial name
- NCT07213245
- Testing
- Meal high in energy density, high in ultra-processed food, Meal high in energy density, low in ultra-processed food, Meal low in energy density, high in ultra-processed food
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Obesity and Obesity-related Medical Conditions
Bariatric Surgery vs. Semaglutide vs. Tirzepatide
The recent introduction of the new generation of anti-obesity medications (AOMs) will change the future of obesity treatment. These highly effective medications, such as high-dose semaglutide and tirzepatide, are hormone…
- Trial name
- NCT06803888
- Testing
- Bariatric Surgery, Semaglutide, Tirzepatide
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Ali Aminian
Obesity and Obesity-related Medical Conditions, Weight Loss
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
The objective of this study is to assess the long term weight loss and weight loss journey of patients who received an Endoscopic Sleeve Gastroplasty (ESG) 5 or more years prior to enrollment.
- Trial name
- LIGHT (NCT06894498)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Boston Scientific Corporation
Healthy, Fatty Liver
Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease
A generic screening study to establish structural and/or functional baselines of specific organs.
- Conditions
- Healthy, Fatty Liver, MASLD, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
- Trial name
- MASLD (NCT04873258)
- Testing
- Bioimpedence Vector Analysis
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Richmond Research Institute
Weight Management, Obesity Prevention
Advancing Biopsychosocial Care Training Initiative
This project will compare two training approaches for US Preventive Services Task Force recommended obesity care in Federally Qualified Health Centers (FQHC) across four aims.
- Conditions
- Weight Management, Obesity Prevention, Obesity and Obesity-related Medical Conditions, Obesity and Overweight
- Trial name
- ABC Initiative (NCT07049861)
- Testing
- Comprehensive Multidisciplinary Obesity Care, Implementation as Usual Control
- Where
- United States
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity and Obesity-related Medical Conditions, Spinal Cord Injury, Chronic
UTSW NORC Pilot Spinal Cord Injury Dietary Program
The goal of this observational study is to learn about the effects of a 9-week dietician-guided program modified from the National Diabetic Prevention Program (modified DPP-diet) in people with spinal cord injury on body…
- Trial name
- NCT06924177
- Testing
- Telehealth with dietician
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Obesity and Obesity-related Medical Conditions
A Study of MET233 in Combination With MET097 in Individuals With Obesity or Overweight With or Without Diabetes
This study is designed to test how well the combination of MET233 with MET097 works to treat individuals with obesity or overweight with or without diabetes.
- Trial name
- NCT06924320
- Testing
- MET233 and MET097, MET097
- Where
- United States
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity and Obesity-related Medical Conditions
Evaluation of a Primary Care Based Lifestyle Medicine Clinic at UAB
This is a randomized quality improvement project (i.e., not a research study) that will test the implementation and effectiveness of a lifestyle medicine clinic at the University of Alabama at Birmingham.
- Trial name
- NCT06989281
- Testing
- FLOW Lifestyle Medicine Clinic
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Alabama at Birmingham
Smoking Cessation, Obesity and Obesity-related Medical Conditions
Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy
This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.
- Trial name
- CRESCENT (NCT06948058)
- Testing
- Electronic Cigarettes (EC), Nicotine replacement therapy (NRT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brown University
Obesity and Obesity-related Medical Conditions, Bariatric Surgery
2024 Tirzepatide-Bariatric Surgery
This clinical trial will test whether preoperative tirzepatide treatment improves outcomes after bariatric surgery. The outcome of this study could impact therapeutic guidelines for the multimodal treatment of obesity.
- Trial name
- NCT06721507
- Testing
- tirzepatide, Standard of Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Marlene Starr
Prehypertension (Elevated Blood Pressure) or Hypertension, Obesity and Obesity-related Medical Conditions
Evaluation of Physical Fitness and Hemodynamics Across a Diverse Population
In this study, investigators will use the IFT 30-15 test, a six-minute walking test, and a treadmill test to assess the participants' cardiorespiratory fitness.
- Trial name
- ACT-ON-s1 (NCT06669715)
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Obesity and Obesity-related Medical Conditions
Egg Intake, Metabolic Outcomes and Choline Levels
The purpose of this research is to determine the effect of additional daily egg intake on metabolic phenotypes and metabolism in the context of obesity.
- Trial name
- NCT06687122
- Testing
- 3 whole eggs
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Obesity and Obesity-related Medical Conditions
Effect of Betaine and Choline on Metabolic Health
The purpose of this research is to determine whether extra betaine and choline influence metabolic health in adults with overweight and obesity.
- Trial name
- NCT06758856
- Testing
- Trimethylglycine, Eggs, Cellulose
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Obesity and Obesity-related Medical Conditions, Psychiatric Disorders
Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients
A significant number of patients who are prescribed anti-psychotic medication such as clozapine are considered as clinically obese (BMI >35.0).
- Trial name
- STEP@STAH (NCT06754163)
- Testing
- Semaglutide in combination with a healthy lifestyle intervention (diet and exercise)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- St Andrew's Healthcare