Clinical trials: Obesity, Morbid, open to volunteers
Carcinoma, Hepatocellular, Metabolic Syndrome
Liver Resection and Simultaneous Sleeve Gastrectomy for MS-HCC (LIRESS)
Hepatocellular carcinoma (HCC) related to metabolic syndrome (MS) as unique risk factor is gradually overpassing the more common viral and alcohol etiology, becoming a global health issue.
- Trial name
- LIRESS (NCT06060847)
- Testing
- Liver resection and simultaneous sleeve gastrectomy for HCC induced by metabolic syndrome, Liver resection for HCC induced by metabolic syndrome
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale V. Fazzi
Bariatric Surgery, Bone Health
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
Background: Bariatric surgery is gaining in popularity. While it's health benefits are undisputed, the older malabsorptive bariatric procedures (Roux-in-Y gastric bypass - RYGB and biliopancreatic diversion - BPD) are associated…
- Conditions
- Bariatric Surgery, Bone Health, Severe Obesity, Muscle Health
- Trial name
- BONUS (NCT06547515)
- Testing
- Bariatric surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- CHU de Quebec-Universite Laval
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476551
- Testing
- Hydrochlorothiazide
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Morbid, Intubation; Difficult or Failed
Comparison of Airtraq in Class 2-3 Obese and Nonobese Men During Intubation: a Prospective Randomized Clinical Study
Morbid obesity is a growing disease. Intubations of these patients mostly difficult. Video laryngoscopes have to be used during the intubation of these patients.
- Conditions
- Obesity, Morbid, Intubation; Difficult or Failed, Video Laryngoscope, Men
- Trial name
- NCT05927519
- Testing
- airtraq video laryngoscope
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Obesity; Drug, Obesity, Morbid
Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet
The goal of this clinical trial is to assess the impact of combination therapy with Naltrexone-Bupropion (NB) in the post-operative period of sleeve gastrectomy (SG).
- Trial name
- NCT06620562
- Testing
- Naltrexone/Bupropion
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Laval University
Obesity, Morbid, Bariatric Surgery Candidate
Impact of Bariatric Surgery on Heart Disease Compared to Standard Care
Obesity is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). Metabolic and bariatric surgery (MBS) has in several randomized controlled trials (RCT) been shown to be superior to best medical therapy in the…
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, Heart Diseases
- Trial name
- MIMS (NCT06346145)
- Testing
- Bariatric surgery, Standard care
- Volunteers
- 500 people
- Sponsor
- Danderyd Hospital
Obesity, Insulin Resistance
Collection of Human Metabolic Tissues
This project aims at identifying new determinants of type 2 diabetes in severe obesity. To do so, a biological collection, including tissues of interest in the field of metabolism, will be collected during bariatric surgery in…
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- COMET (NCT02861781)
- Testing
- Collection of blood samples and tissues
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Montpellier
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Ibuprofen
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476577
- Testing
- Ibuprofen
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Obesity
RCT Comparing OAGB and Long Limb Roux Gastric Bypass
A prospective multicenter randomized controlled trial to compare the outcomes of one-anastomosis gastric bypass to long biliary limb Roux gastric bypass.
- Trial name
- OAGBvsLLbypass (NCT04812132)
- Testing
- One-anastomosis gastric bypass, Long biliary limb Roux gastric bypass
- Where
- Estonia
- Volunteers
- 500 people
- Sponsor
- Tartu University Hospital
Anesthesia, Opioid
The Effect of Opioid Free Anesthesia Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion
This study aimed to determine the effects of Opioid-free anesthesia using dexmedetomidine and bilateral Transversus abdominis plane block on the quality of recovery, incidence of Opioid-free anesthesia, and post-operative pain…
- Conditions
- Anesthesia, Opioid, Gynecological Surgery
- Trial name
- NCT07114237
- Testing
- Opioid Free Anesthesia, Control group (general anesthesia)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Leptin Receptor Deficiency Obesity
Targeting the Hepatic BMP-SMAD Pathway in Leptin Receptor Deficiency (LEPRD)
The goal of this observational study is to learn more about the role of TMPRSS6 in patients with leptin receptor deficiency (LEPRD) or genetic lipodystrophy associated with leptin deficiency.
- Trial name
- THOLD (NCT07833592)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Obesity, Morbid, Bariatric Surgery Candidate
Database Maintenance for Bariatric Procedures
Bariatric surgery registry for quality control and investigational purposes.
- Trial name
- NCT04040413
- Testing
- bariatric surgery
- Where
- Israel
- Volunteers
- 5,000 people
- Sponsor
- Sheba Medical Center
Endometrial Cancer, Endometrial Neoplasms
Robotic-assisted Versus Conventional Laparoscopic Surgery in Obese Patients With Early Endometrial Cancer
Data across literature suggest that robotic surgery may offer benefit specifically in patient with morbid obesity with endometrial cancer, but to date no randomized trials have been conducted to confirm these observations.
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Obesity, Morbid, Gynecologic Cancer
- Trial name
- RObese (NCT05974995)
- Testing
- Robot-assisted surgery, Laparoscopic surgery
- Where
- Italy
- Volunteers
- 566 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Ramipril
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03440177
- Testing
- Ramipril
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Bariatric Surgery, Obesity, Morbid
Periodontal Microbiota of Patients Candidates for Bariatric Surgery With Body Mass Index Greater Than 30
The goal of this observational study is to compare the microbiological composition of the periodontal plaque of obese people undergoing bariatric surgery according to their Body Mass Index.
- Trial name
- OROBESITE (NCT06781229)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Morbid Obesity
Tapered Versus Abrupt Discontinuation of Semaglutide After Treatment of Recurrent Weight Gain or Suboptimal Response Following Metabolic and Bariatric Surgery
Every course of obesity pharmacotherapy ends. Cost, supply, pregnancy plans, side effects, or the patient's own wish. In Egypt, cost alone makes discontinuation the rule, not the exception.
- Trial name
- NCT07859176
- Testing
- Semaglutide weekly injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Gastroesophageal Reflux Disease, Morbid Obesity
Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: An 8-Year Prospective Cohort Study
This study represents a long-term observational follow-up of patients who had previously undergone bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) in the context of an earlier interventional trial…
- Trial name
- NCT03692455
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Clinica Gastrobese